Public health relevance of drug–nutrition interactions

Navis, Gerjan; Borst, Martin H. de; Schacky, Clemens von; Orten-Luiten, A.C.B. van; Zhernakova, Alexandra; Witkamp, Renger F.; Janse, A.; Weber, Peter; Bakker, Stephan J. L.; Eggersdorfer, Manfred

doi:10.1007/s00394-017-1510-3

Cited by 39 publications

(33 citation statements)

References 114 publications

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“…The University Medical Center Groningen (UMCG) in The Netherlands organizes annual symposia within the compass of medicine and nutrition, as part of its Healthy Ageing program. Previously published proceedings of these symposia have examined the relationship of nutrients with lifelong health and disease [ 1 ], with healthy aging [ 2 ], with malnutrition and obesity [ 3 ], and with nutrient–drug interactions [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The role of the microbiome for human health: from basic science to clinical applications

et al. 2018

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The 2017 annual symposium organized by the University Medical Center Groningen in The Netherlands focused on the role of the gut microbiome in human health and disease. Experts from academia and industry examined interactions of prebiotics, probiotics, or vitamins with the gut microbiome in health and disease, the development of the microbiome in early-life and the role of the microbiome on the gut–brain axis. The gut microbiota changes dramatically during pregnancy and intrinsic factors (such as stress), in addition to extrinsic factors (such as diet, and drugs) influence the composition and activity of the gut microbiome throughout life. Microbial metabolites, e.g. short-chain fatty acids affect gut–brain signaling and the immune response. The gut microbiota has a regulatory role on anxiety, mood, cognition and pain which is exerted via the gut–brain axis. Ingestion of prebiotics or probiotics has been used to treat a range of conditions including constipation, allergic reactions and infections in infancy, and IBS. Fecal microbiota transplantation (FMT) highly effective for treating recurrent Clostridium difficile infections. The gut microbiome affects virtually all aspects of human health, but the degree of scientific evidence, the models and technologies and the understanding of mechanisms of action vary considerably from one benefit area to the other. For a clinical practice to be broadly accepted, the mode of action, the therapeutic window, and potential side effects need to thoroughly be investigated. This calls for further coordinated state-of-the art research to better understand and document the human gut microbiome’s effects on human health.

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Section: Introductionmentioning

confidence: 99%

The role of the microbiome for human health: from basic science to clinical applications

et al. 2018

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“…However, an overdose of vitamins can be toxic in nature [ 16 , 17 , 18 , 19 , 20 ]. In addition, interactions of vitamins and other drugs are often reported [ 21 ]. Consequently, in order to use vitamins reasonably, it is essential to develop rapid, accurate, reliable and efficient methods for the simultaneous separation and quantitation of multiple vitamins in different matrices.…”

Section: Introductionmentioning

confidence: 99%

A Review of the Extraction and Determination Methods of Thirteen Essential Vitamins to the Human Body: An Update from 2010

et al. 2018

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Vitamins are a class of essential nutrients in the body; thus, they play important roles in human health. The chemicals are involved in many physiological functions and both their lack and excess can put health at risk. Therefore, the establishment of methods for monitoring vitamin concentrations in different matrices is necessary. In this review, an updated overview of the main pretreatments and determination methods that have been used since 2010 is given. Ultrasonic assisted extraction, liquid–liquid extraction, solid phase extraction and dispersive liquid–liquid microextraction are the most common pretreatment methods, while the determination methods involve chromatography methods, electrophoretic methods, microbiological assays, immunoassays, biosensors and several other methods. Different pretreatments and determination methods are discussed.

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“…The extracted statements were assigned to one of five classes (Table 1) 16 . A distinction was made between the effects of nutrition status, foods or specific nutrients on drug action; and conversely, the effects of drug use on determinants of nutrition status.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial drug-nutrition interactions: Consistency of information for generic drugs

Nikolic

2020

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Introduction/Aim. Antimicrobial drug-nutrition interactions can compromise the efficacy and safety of therapeutic regimen, as well as the nutritional status of the patient. In order to prevent them, health professionals consult the reference sources of information. Summary of Product Characteristics (SmPC) is the basis for reliable and objective informing, and in the case of generic products the content of documents should be consistent. The aim of the study was to compare information on antimicrobial drug-nutrition interactions for generic products, and to consider the influence of relevant factors (the time of the first authorization and the number of generic products) on the outcome of evaluation. Methods. SmPCs for all generic antimicrobial products for systemic use were retrieved from the Medicines and Medical Devices Agency of Serbia website, and statements of interest were extracted from different sections and were compared. The comparison was based on classification of statements on interaction into one of five classes: "effect of nutrition status on drug action", "effect of food in general on drug action", "effect of specific nutrient on drug action", "effect of drug on nutrient and metabolic status", or "effect of drug on nutrition status". Results. A total of 160 SmPCs were evaluated for 30 antimicrobial drugs corresponding to 46 dosage forms (mean number 3.48 (SD=1.68); median 3.00 (IQR=2); range: 2-9). Nine (30%) antimicrobials (azithromycin, clarithromycin, cefazolin, cefepime, pipemidic acid, ciprofloxacin, levofloxacin, moxifloxacin and gentamicin) had inconsistent information. The inconsistency was related to different classes of interactions, and in some cases it could have clinically important implications (gentamicin, fluoroquinolones). The existence of a larger number of generic products was related to identified differences (p=0.003). Conclusion. One third of generic antimicrobial products had inconsistent drug-nutrition interaction statements. Given the potential clinical implications, strategies for further harmonization of information should be considered. ApstraktUvod/Cilj. Interakcije antimikrobnih lekova i hrane mogu kompromitovati efikasnost i bezbednost terapijskog režima, kao i nutritivni status pacijenta. Kako bi prevenirali iste, zdravstveni profesionalci konsultuju referentne izvore informacija. Sažetak karakteristika leka (eng. Summary of Product Characteristics, SmPC) je osnov pouzdanog i objektivnog informisanja, i u slučaju generičkih proizvoda sadržaj dokumenata bi trebalo da je konzistentan. Cilj istraživanja je bio za generičke antimikrobne proizvode komparirati informacije o interakcijama sa hranom, i razmotriti uticaj relevantnih faktora (vreme prve autorizacije i broj generičkih proizvoda) na ishod analize.Metode. SmPCs za sve generičke antimikrobne proizvode za sistemsku upotrebu su preuzeti sa veb-sajta Agencije za lekove i medicinska sredstva Srbije; i iskazi od značaja su ekstrahovani iz različitih sekcija dokumenta i komparirani. Komparacija je bila bazirana na kla...

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Public health relevance of drug–nutrition interactions

Cited by 39 publications

References 114 publications

The role of the microbiome for human health: from basic science to clinical applications

The role of the microbiome for human health: from basic science to clinical applications

A Review of the Extraction and Determination Methods of Thirteen Essential Vitamins to the Human Body: An Update from 2010

Antimicrobial drug-nutrition interactions: Consistency of information for generic drugs

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