“…Initial examinations of estrogens in urine of male adolescents demonstrated increased estrogen production in patients with pubertal gynecomastia [18,19,22], but these observations were not confirmed by more specific methods [6,13]. Changes in androgenestrogen ratio during adolescent development are also discussed [3,5,7,10,20,21,26]. Testosterone levels in 5 patients with pubertal gyneeomastia examined by Wieland [26] were similar to those observed in a large group of normal adolescents.…”