Pubertal upregulation of erythropoiesis in boys is determined primarily by androgen

Hero, Matti; Wickman, Sanna; Hanhijärvi, Raija; Siimes, Martti A.; Dunkel, Leo

doi:10.1016/j.jpeds.2004.09.002

Cited by 79 publications

(73 citation statements)

References 29 publications

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“…Interestingly, boys with delayed puberty have hemoglobin levels similar to those of prepubertal boys and girls, and treatment with testosterone normalizes hemoglobin levels to those observed in the late male puberty. 2,3 These data suggest that testosterone contributes to the 1-to 2-g/dL difference in hemoglobin concentration between adult men and women. If testosterone stimulates erythropoiesis in adults, it is reasonable to hypothesize that a decline in testosterone levels with aging may negatively affect erythropoiesis.…”

Section: Discussionmentioning

confidence: 85%

Low Testosterone Levels and the Risk of Anemia in Older Men and Women

et al. 2006

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Section: Discussionmentioning

confidence: 85%

Low Testosterone Levels and the Risk of Anemia in Older Men and Women

et al. 2006

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“…In particular, male adolescents tended to have higher Hb levels, probably reflecting the physiologic increase in erythropoiesis in response to rising androgen production during puberty. 32 We are aware of the limitations of this global cohort study. The observational nature of the registry largely precludes interpretations of cause-effect relationships because of potential bias by indication.…”

Section: Discussionmentioning

confidence: 96%

Management of Anemia in Children Receiving Chronic Peritoneal Dialysis

Borzych-Dużałka

Bilginer

et al. 2013

Journal of the American Society of Nephrology

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Little information exists regarding the efficacy, modifiers, and outcomes of anemia management in children with CKD or ESRD. We assessed practices, effectors, and outcomes of anemia management in 1394 pediatric patients undergoing peritoneal dialysis (PD) who were prospectively followed in 30 countries. We noted that 25% of patients had hemoglobin levels below target (,10 g/dl or ,9.5 g/dl in children older or younger than 2 years, respectively), with significant regional variation; levels were highest in North America and Europe and lowest in Asia and Turkey. Low hemoglobin levels were associated with low urine output, low serum albumin, high parathyroid hormone, high ferritin, and the use of bioincompatible PD fluid. Erythropoiesis-stimulating agents (ESAs) were prescribed to 92% of patients, and neither the type of ESA nor the dosing interval appeared to affect efficacy. The weekly ESA dose inversely correlated with age when scaled to weight but did not correlate with age when normalized to body surface area. ESA sensitivity was positively associated with residual diuresis and serum albumin and inversely associated with serum parathyroid hormone and ferritin. The prevalence of hypertension and left ventricular hypertrophy increased with the degree of anemia. Patient survival was positively associated with achieved hemoglobin and serum albumin and was inversely associated with ESA dose. In conclusion, control of anemia in children receiving long-term PD varies by region. ESA requirements are independent of age when dose is scaled to body surface area, and ESA resistance is associated with inflammation, fluid retention, and hyperparathyroidism. Anemia and high ESA dose requirements independently predict mortality.

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“…This direct effect is mediated through the induction of insulinlike growth factor (IGF-1) of the androgen-receptor mediated mechanism. 34 In the available literature, there is evidence that testosterone enhances the absorption of iron, its incorporation into red blood cells and hemoglobin synthesis. 35 Testosterone-induced increase in hematocrit and hemoglobin is associated with elevated erythropoietin levels, but this is also accompanied by other mechanisms, such as reduced hepcidin (the ironregulatory peptide) and ferritin.…”

Section: Discussionmentioning

confidence: 99%

Comparison in haematological and biochemical changes in normal, acute and chronically castrated West African Dwarf goats

Olaifa

2018

Int J Res Med Sci

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Background: Castration is one of the frequent management practices in large animal husbandry and burdizzo castration has been shown to produce fewer long-term behavioral signs of pain and distress than banding. Castration is known to reduce virility and aggression due to the elimination of testicular androgens. Methods: This is a comparative study of hematological and biochemical parameters in intact, acute and chronically castrated West African dwarf goats. Twelve adult West African Dwarf bucks weighing between 8 to 14 kg randomly divided into 3 groups of intact, acute and chronic castrated. They were castrated using burdizzo castrator. Hematological and biochemical parameters were estimated by standard laboratory procedures. Results: There were significant decreases (P<0.05) in the PCV, Hb, RBC, WBC and MCH of acute and chronically castrated goat compared to the control group. The MCV and platelets increased significantly in acute and chronically castrated goat; while the neutrophil and lymphocyte showed no significant changes. The result also showed no significant changes in Na , AST and Creatinine. Mg 2+ and ALT significantly increased in chronically castrated goats compared with the acutely castrated goats while Zinc increased significantly (P<0.05) in acute castrated compared with the control goats. Conclusions: Therefore, from this study, either acute or chronic castration in goats have no detrimental effect on blood electrolytes, but mainly deter the hematopoietic process in the animal owing to testosterone and androgen depletion in castrate animals.

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Pubertal upregulation of erythropoiesis in boys is determined primarily by androgen

Cited by 79 publications

References 29 publications

Low Testosterone Levels and the Risk of Anemia in Older Men and Women

Low Testosterone Levels and the Risk of Anemia in Older Men and Women

Management of Anemia in Children Receiving Chronic Peritoneal Dialysis

Comparison in haematological and biochemical changes in normal, acute and chronically castrated West African Dwarf goats

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