Low Testosterone Levels and the Risk of Anemia in Older Men and Women

Ferrucci, Luigi; Maggio, Marcello; Bandinelli, Stefania; Basaria, Shehzad; Lauretani, Fulvio; Blé, Alessandro; Valenti, Giorgio; Ershler, William B.; Guralnik, Jack M.; Longo, Dan L.

doi:10.1001/archinte.166.13.1380

Cited by 233 publications

(159 citation statements)

References 41 publications

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“…Lower testosterone levels are also predictive of anemia in older men, supporting its role as a marker of poorer overall health outcomes. 61,62 In keeping with these observations, over a third of men aged X45 years visiting primary care practices either for general health checks or with specific illnesses had serum total testosterone o10.4 nmol l À1 . 63 Overviews of randomized controlled trials of testosterone therapy in men without or with underlying chronic illness using a variety of testosterone formulations report improvements in body composition with increased lean body mass and reduced fat mass, but limited benefit in physical capabilities and equivocal improvements in quality of life measures, including general well-being and fatigue.…”

Section: Testosterone General Health and Quality Of Life In Aging Menmentioning

confidence: 61%

Are declining testosterone levels a major risk factor for ill-health in aging men?

Yeap

2008

Int J Impot Res

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As men grow older, testosterone levels fall, with a steeper decline in unbound or free testosterone compared with total testosterone concentrations. Lower testosterone levels have been associated with poorer cognitive function, and with impaired general and sexual health in aging men. Recently, lower testosterone levels have been linked with metabolic syndrome and type II diabetes, both conditions associated with cardiovascular disease, and shown to predict higher overall and cardiovascular-related mortality in middle-aged and older men. However, reverse causation has to be considered, as systemic illness may result in reduced testosterone levels. Thus, the strength of these associations and the likely direction of causation need to be carefully considered. Furthermore, these conditions may overlap, for example aging, lower testosterone levels, erectile dysfunction and cardiovascular disease are interrelated. Cross-sectional and longitudinal observational studies may be informative. However, ultimately randomized controlled trials of testosterone therapy are needed to clarify its role in the maintenance of general and sexual health in aging men. Testosterone therapy should be considered in hypogonadal men who meet rigorous criteria for the diagnosis of androgen deficiency. Additional consideration should be given to designing and testing interventions that may prevent or ameliorate the age-related decline in testosterone levels in men.

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Section: Testosterone General Health and Quality Of Life In Aging Menmentioning

confidence: 61%

Are declining testosterone levels a major risk factor for ill-health in aging men?

Yeap

2008

Int J Impot Res

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“…28 Ferrucci and colleagues reported that men in the lowest quartile of total and bioavailable testosterone were more likely to have anemia. 29 Although we did not study serum testosterone lev� els in this study, the lower hemoglobin in the varicocele group could be associated with low testosterone levels.…”

Section: Coban Et Almentioning

confidence: 78%

Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels?

Çoban

Ibrahim

Bıyık

et al. 2015

CUAJ

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Introduction: There are several studies on the relationship between increased mean platelet volume (MPV) and varicocele. �e inves� �e inves� tigated the relationship between preoperative and 6�month post� operative MPV values in patients whose varicocele was corrected with surgery. Methods: A total of 282 patients underwent surgery at our urology clinic between December 2011 and December 2013 for primary varicocele. �e retrospectively examined the records of 61 patients who came to the 6�month postoperative follow�up. The preop� erative varicocele diagnosis was made with physical examination findings and supported with colour Doppler ultrasonography. Results: The varicocele was grade I in 12 patients, grade II in 34 patients and grade III in 11 patients. �hen the preoperative and 6�month postoperative haemoglobin (Hb), MPV, mean corpuscular volume, platelet, and platelet distribution width (PD�) values were compared, there was a significant decrease in MPV (p = 0.019), and a significant increase in Hb (p < 0.001). A noticeable increase was also present in PD�, but it was not statistically significant (p = 0.058). Conclusion: �e found that MPV increased in patients with varic� ocele and tended to decrease again after the varicocele was sur� gically corrected. However, we feel larger prospective series are needed.

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“…Low T has been related to lower hemoglobin (Hb) levels and a higher risk to develop chronic anemia in older patients [123]. Men under androgen deprivation therapy are more frequently anemic [123].…”

Section: Anemiamentioning

confidence: 99%

“…Men under androgen deprivation therapy are more frequently anemic [123]. Hb levels are related to the severity of androgen deficiency [11] and increase in a linear, dose-dependent manner after TRT [124].…”

Section: Anemiamentioning

confidence: 99%

See 1 more Smart Citation

A view of geriatrics through hormones. What is the relation between andropause and well-known geriatric syndromes?

Samaras

Lang

et al. 2013

Maturitas

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a b s t r a c tAge related male hypogonadism, or "andropause", is increasingly recognized as of frequent occurrence in older patients. Diagnosis requires both the presence of clinical symptoms and low testosterone levels. However, diagnosing andropause in this age group may be challenging since symptoms are frequently non specific and testosterone levels are influenced by a multitude of parameters such as lifestyle factors and chronic diseases. In this article we discuss the pathophysiology, definition and diagnostic difficulties of andropause in geriatric patients. Moreover, we review the relation between testosterone levels and frequent geriatric syndromes such as falls, osteoporosis, cognitive and mood disorders, anemia and cardiovascular disease. Finally, we examine the potential benefits and risks of testosterone replacement therapy in this age group.

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Low Testosterone Levels and the Risk of Anemia in Older Men and Women

Abstract: Older men and women with low testosterone levels have a higher risk of anemia.

Cited by 233 publications

References 41 publications

Are declining testosterone levels a major risk factor for ill-health in aging men?

Are declining testosterone levels a major risk factor for ill-health in aging men?

Does varicocele correction lead to normalization of preoperatively elevated mean platelet volume levels?

A view of geriatrics through hormones. What is the relation between andropause and well-known geriatric syndromes?

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