Pubertal evaluation of adolescent boys with β-thalassemia major and delayed puberty

Al-Rimawi, Hala S.; Jallad, M. F.; Amarin, Zouhair; Sakaan, Rula Al

doi:10.1016/j.fertnstert.2006.02.118

Cited by 12 publications

(12 citation statements)

References 17 publications

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“…This suggested that testicular function is diminished, although they have a normal pubertal onset. Rimawi et al [5] reported that the basal levels of serum testosterone in patients with thalassemia who have a normal puberty, were lower than in normal controls, but this was not significantly different. However, significant differences were seen after a GnRH stimulation test.…”

Section: Discussionmentioning

confidence: 95%

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Testicular function in patients with regular blood transfusion for thalassemia major

et al. 2015

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Background: Regular blood transfusion and iron chelation therapy have improved the quality of life of patients with thalassemia and increased their longevity, but transfusion also increases the frequency of endocrine complications, possibly because of iron deposition in the pituitary gland or the gonads, or both. Objective: To evaluate testicular function in patients with thalassemia major by basal hormonal study, and identify risk factors for dysfunction. Methods: We performed a cross-sectional study of 28 patients with thalassemia major aged 11.7 ± 1.8 (8−14.9) years (15 in prepuberty, 13 in puberty with no delayed puberty) who had regular blood transfusions. A normal control group comprised 64 boys who were matched for age and Tanner genital stage. Results: The mean level of serum ferritin in the previous year was 1,575 ± 642 ng/mL, and the onset of blood transfusion was at 3.8 ± 2.3 years and iron chelation therapy was 6.6 ± 2.8 years. The trend for anti-Müllerian hormone levels in patients and controls was similar with age, and although higher in the patients, particularly at Tanner stage II, was not significantly different. Testosterone levels were lower in the patients compared with controls; particularly at Tanner stages IV-V (290.88 vs. 537.4 ng/dL, P < 0.05). Serum follicle-stimulating hormone and luteinizing hormone levels were not significantly different between the groups at any Tanner stage. Conclusion: Patients who received regular blood transfusions had normal Sertoli cell function. Leydig cell dysfunction may occur, even though the patients had a normal pubertal onset.

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Section: Discussionmentioning

confidence: 95%

“…These result from iron deposition in the pituitary gland, testicular tissue, or both. Prevalence is 40%−80% [5][6][7][8][9]. Iron overload [10][11][12] is considered one of the main factors for developing endocrine complications.…”

Section: Brief Communication (Original)mentioning

confidence: 99%

Testicular function in patients with regular blood transfusion for thalassemia major

et al. 2015

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“…Hypogonadism is one of the most frequent endocrine complications in thalassemia patients. [8] Despite recent therapeutic advances in the management of beta-thalassemia major, the risk of secondary endocrine dysfunction remains high.…”

Section: Discussionmentioning

confidence: 99%

“…Hypogonadism was one of the most frequent endocrine complications seen in one study. [8] Impaired glucose tolerance, short stature, hypocalcemia, and subclinical and overt hypothyroidism are also frequent. [9]…”

Section: Introductionmentioning

confidence: 99%

Study of the effect of iron overload on the function of endocrine glands in male thalassemia patients

Abdulzahra¹,

Al‐Hakeim²,

Ridha³

2011

Asian J Transfus Sci

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Background:Iron overload is an important issue in the state of thalassemic patients due to the harmful effect of high concentration of iron deposited in different tissues in human body including endocrine glands. In the present work, an attempt is carried out to estimate the effect of iron overload in thalassemic patients on the function of endocrine glands through the estimation of their ability to secrete adequate amounts of certain hormones.Materials and Methods:Seventy eight male children with beta-thalassemia, in the age-group of 4–11 years, were enrolled for this research. These children were being treated with frequent transfusions and long-term iron chelation therapy. Thirty age and sex matched children without thalassemia constituted the control group. Ferritin and different hormones were estimated by ELISA technique.Results:The results showed a mild reduction in the function of endocrine glands through the decrease in the level of some hormones. These changes due mainly to the hypoxia and precipitation of iron in certain glands and overlapping with the synthesis or secretion of the hormones.Conclusion:There is a different hormonal disturbances in beta thalassemia patients. Reduction of total body iron store is an important goal of the treatment of thalassemia and measuring the hormones concentration is necessary for the follow up of the thalassemic patients especially during puberty.

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“…In addition, this study encourages the regular assessment of growth, development, and testicular function in pediatric patients with thalassemia to detect abnormalities early and initiate early treatment. The prevalence of hypogonadism and delayed puberty in Thai pediatric patients is substantially lower than that in previous reports [10][11][12]. This is likely to be because of the different population studied.…”

mentioning

confidence: 55%

Comprehensive care for thalassemia: not just the treatment of anemia

Uarpasert

2015

Asian Biomedicine

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Pubertal evaluation of adolescent boys with β-thalassemia major and delayed puberty

Cited by 12 publications

References 17 publications

Testicular function in patients with regular blood transfusion for thalassemia major

Testicular function in patients with regular blood transfusion for thalassemia major

Study of the effect of iron overload on the function of endocrine glands in male thalassemia patients

Comprehensive care for thalassemia: not just the treatment of anemia

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