Pubertal age based on testicular and epididymal histology in Göttingen minipigs

Taberner, E.; Navratil, Nicole; Jasmin, B. J.; Salerno, Monica; Grambo, B.; Althouse, GC

doi:10.1016/j.theriogenology.2015.07.030

Cited by 13 publications

(7 citation statements)

References 18 publications

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“…Interestingly, BP estimates are very close to those achieved by Kangawa (Kangawa et al., 2016) in microminipigs (18 weeks). These numbers are outdated by some minipigs strains, like Gottingen (8 weeks) (Tab erner et al., 2016) or Naga (Karunakaran et al., 2009), and Asian highly prolific breeds, like Meishan (8 to 12 weeks) (Lunstra et al., 1997; White et al., 1993). It also confirms some subjective reports from farmers and breeding records from the Breeders association (Paixão et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of gonadal macroscopic and microscopic morphometry reveals precocious puberty in Bísaro pig

Paixão

Esteves

Carolino

et al. 2020

Reprod Domestic Animals

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Bísaro pig (BP) population has grown in numbers in the last decade, representing today one of the most important Portuguese livestock breeds (Paixao et al., 2018). Yet, the high-end cured products, which drove this growth, no longer represent the major production of this breed. Difficulties to comply with EU welfare regulations are being pointed out as the main factor involved in this phenomenon. This is especially important when it refers to surgical castration restrictions introduced by the Council Directive 2008/120/EC from December 2008, specifying that surgical castration of pigs shall only be performed with prolonged analgesia and/or anaesthesia. Comprising a large number of smallholders and free-range farms (Paixao et al., 2018), Bísaro producers face many handling constraints to rear young animals up to 14 months of age for cured meat products. Rearing entire animals, with modified feedstuff or improved genetics to lower androstenone and skatole levels in the carcase and thus boar taint, could be pointed as an alternative to physical castration (Backus et al., 2016; Heyrman et al., 2018). Yet, these strategies are less reliable in animals of such age. In local breeds with no consistent breeding programs immunocastration is also suggested as valid alternative to surgical castration (De Briyne et al., 2016; Prunier et al., 2006) even though the effectiveness of this method is yet to prove in

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Section: Discussionmentioning

confidence: 99%

Evaluation of gonadal macroscopic and microscopic morphometry reveals precocious puberty in Bísaro pig

Paixão

Esteves

Carolino

et al. 2020

Reprod Domestic Animals

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“…This marked difference, which is very important in terms of selection of animals for studies and interpretation of experimental results, may be linked with how maturity was defined in the 2 studies but alternatively could be due to intrinsic interstrain differences or to husbandry differences. The authors of this review suggest that it may be useful for a panel of pathologists to reexamine the sections reported by Evans et al (2012) and Taberner et al (2015) simultaneously in order to ensure that consistent histological criteria have been applied. It would also be useful in future work to correlate the histological appearances of the maturing testis and epididymides with those of the prostate and seminal vesicles.…”

Section: Discussionmentioning

confidence: 99%

Review of Sexual Maturity in the Minipig

Howroyd¹,

Peter

Rijk

2016

Toxicol Pathol

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It is important to know whether the animals used in toxicology studies are sexually mature. As minipigs are being used increasingly in toxicity studies, we reviewed published data on the age of sexual maturity in the minipig. Maturity in females was assessed on the basis either of normal cycles of progesterone secretion or of the histological presence of corpora lutea and, in males, was assessed on the histological appearance of the seminiferous tubules and epididymides. In female Gö ttingen minipigs, the first progesterone peak was at 3.7 to 4.2 or 6.1 to 6.5 months of age. These animals were in the presence of a boar. In female Gö ttingen minipigs in toxicology studies, which were not in the presence of a boar, at least 1 corpus luteum in the ovaries was present in only 50% of the females by 6.5 months of age, while all were mature by 7.7 months of age. Histological maturity in the male Yucatan minipig is reported to be attained at about 4.4 months old, but in male Göttingen minipigs at about 2 months old, although the definition of maturity may have been different in the 2 studies.

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“…As with the NHP, there is high inter‐animal and high strain variability in timing of maturation. Gottingen minipigs at 4 months of age can be prepubertal to adult (Bode et al, ), and Gottingen pigs may have onset of puberty as early as 2 months of age (Evans et al, ), or as early as 6 to 7 weeks of age (Taberner et al, ). Gottingen pigs generally have onset of puberty approximately 2 months earlier than their Yucatan counterparts, and Yucatans reach onset of puberty at approximately 3.6 to 4.0 months of age (Evans et al, ).…”

Section: Testesmentioning

confidence: 99%

“…For example, some authors report the day of mating as gestation day (GD) 0 or 1 or consider the day of birth to be postnatal day (PND) 0 or 1, depending on the time of day that parturition is either initiated or completed. While referring to developmental milestones, “sexual maturity” has been used by some authors to indicate onset of puberty, puberty, or early adult stages (Evans et al, ; Howroyd et al, ; Taberner et al, ).…”

Section: Introductionmentioning

confidence: 99%

Comparative Aspects of Pre‐ and Postnatal Development of the Male Reproductive System

Picut

Ziejewski

Stanislaus

2017

Birth Defects Research

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This review describes pre- and postnatal development of the male reproductive system in humans and laboratory animals, and highlights species differences in the timing and control of hormonal and morphologic events. Major differences are that the fetal testis is dependent on gonadotropins in humans, but is independent of such in rats; humans have an extended postnatal quiescent period, whereas rats exhibit no quiescence; and events such as secretion by the prostate and seminal vesicles, testicular descent, and the appearance of spermatogonia are all prenatal events in humans, but are postnatal events in rats. Major differences in the timing of the developmental sequence between rats and humans include: gonocyte transformation period (rat: postnatal day 0-9; human: includes gestational week 22 to 9 months of age); masculinization programming window (rat: gestational day 15.5-17.5; human: gestational week 9-14); and mini-puberty (rat: 0-6 hr after birth; human: 3-6 months of age). Endocrine disruptors can cause unique lesions in the prenatal and early postnatal testis; therefore, it is important to consider the differences in the timing of the developmental sequence when designing preclinical studies as identification of windows of sensitivity for endocrine disruption or toxicants will aid in interpretation of results and provide clues to a mode of action. Birth Defects Research 110:190-227, 2018. © 2017 Wiley Periodicals, Inc.

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Pubertal age based on testicular and epididymal histology in Göttingen minipigs

Cited by 13 publications

References 18 publications

Evaluation of gonadal macroscopic and microscopic morphometry reveals precocious puberty in Bísaro pig

Evaluation of gonadal macroscopic and microscopic morphometry reveals precocious puberty in Bísaro pig

Review of Sexual Maturity in the Minipig

Comparative Aspects of Pre‐ and Postnatal Development of the Male Reproductive System

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