PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans

Peri, Giuseppe; Introna, Martino; Corradi, Domenico; Iacuitti, Giuseppe; Signorini, Stefano; Avanzini, Fausto; Pizzetti, Fabrizio; Maggioni, Aldo P.; Moccetti, Tiziano; Metra, Marco; Dei, Livio; Ghezzi, Pietro; Sipe, Jean D.; Re, Gianpietro; Olivetti, G; Mantovani, Alberto; Latini, Roberto

doi:10.1161/01.cir.102.6.636

Cited by 386 publications

(407 citation statements)

References 30 publications

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“…The blood was processed to obtain plasma and serum samples that were immediately frozen and stored at Ϫ70°C until analysis. The determinations were made in a single run by central laboratory personnel blinded to the experimental groups and included brain natriuretic peptide (BNP, MEIA AxSYM-Abbott, Abbott Park, IL), high-sensitivity cardiac troponin-T (hs-cTnT, Elecsys, Roche Diagnostics, Mannheim, Germany) 16 , pentraxin-3 (PTX3, ELISA based on in-house reagents 17 ), high-sensitive C-reactive protein (hsCRP, turbidimetric method, Beckman Coulter DxC800, Brea, CA), myoglobin (MEIA AxSYM-Abbott), creatine kinase (CK, Rosalki enzymatic method), creatine kinase isoenzyme MB (CK-MB, MEIA Axsym-Abbott, Abbott Park, IL). Urinary albumin excretion was measured using a radioimmunoassay (coated tubes, Immunotech, Marseille, France), indexed to creatinine, and expressed as the urinary albumin-to-creatinine ratio (UACR, mg/g of creatinine).…”

Section: Measurement Of Circulating Biomarkersmentioning

confidence: 99%

Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

Ferratini

Ripamonti

Masson

et al. 2012

Journal of Cardiopulmonary Rehabilitation and Prevention

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■ BACKGROUND: Inflammatory and vascular markers have proved to be predictors of outcome in myocardial infarction and heart failure. We evaluated several circulating markers of cardiac stress, inflammation, and endothelial function to investigate their ability to predict short-term functional recovery and long-term clinical outcome in heart surgery patients undergoing inpatient rehabilitation.■ METHODS: This prospective, multicenter study enrolled 223 patients after heart surgery, included in a 3-week program of standardized and supervised physical training. The association between biomarkers (pentraxin-3 [PTX3], brain natriuretic peptide, high-sensitivity cardiac troponin-T [hs-cTnT] and C-reactive protein [hsCRP], creatine kinase, myoglobin, and urinary albumin excretion [UACR]) and exercise capacity (6-minute walk test, 6MWT) or 1-year incidence of major adverse cardiovascular events (MACE) was tested in models that included biohumoral markers, and clinical and instrumental variables.■ RESULTS: The patients (69.5% men, mean age of 67 Ϯ 11 years) were enrolled after valvular surgery (52.7%) and 58.6% after coronary artery bypass grafting (CABG

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Section: Measurement Of Circulating Biomarkersmentioning

confidence: 99%

Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

Ferratini

Ripamonti

Masson

et al. 2012

Journal of Cardiopulmonary Rehabilitation and Prevention

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“…The levels of PTX3 in plasma or culture supernatant were measured by ELISA, based on mAb MNB4 and rabbit antiserum, as previously described (18). For cell culture experiments cells were grown to confluence in 24-well plates, serum-starved overnight, and then stimulated using DMEM containing 0.25% BSA.…”

Section: Ptx3 Assaymentioning

confidence: 99%

“…This is supported by studies showing the ability of PTX3 to bind to the C1q component of the complement cascade (12) and to participate in the clearance of apoptotic cells (16). Moreover, PTX3 is elevated in critically ill patients, with a gradient from systemic inflammatory response syndrome to septic shock (17), and in several other diseases, such as myocardial infarction (18), rheumatoid arthritis (19), atherosclerosis (20), and small vessel vasculitis (21).…”

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confidence: 99%

The Long Pentraxin Ptx3 Is Synthesized in IgA Glomerulonephritis and Activates Mesangial Cells

Bussolati

Peri

Salvidio

et al. 2003

The Journal of Immunology

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The long pentraxin PTX3 has been recently involved in amplification of the inflammatory reactions and regulation of innate immunity. In the present study we evaluated the expression and role of PTX3 in glomerular inflammation. PTX3 expression was investigated in the IgA, type I membranoproliferative, and diffuse proliferative lupus glomerulonephritis, which are characterized by inflammatory and proliferative lesions mainly driven by resident mesangial cells, and in the membranous glomerulonephritis and the focal segmental glomerular sclerosis, where signs of glomerular inflammation are usually absent. We found an intense staining for PTX3 in the expanded mesangial areas of renal biopsies obtained from patients with IgA glomerulonephritis. The pattern of staining was on glomerular mesangial and endothelial cells. Scattered PTX3-positive cells were also detected in glomeruli of type I membranoproliferative glomerulonephritis. The concomitant expression of CD14 suggests an inflammatory origin of these cells. Normal renal tissue and biopsies from patients with the other glomerular nephropathies studied were mainly negative for PTX3 expression in glomeruli. However, PTX3-positive cells were detected in the interstitium of nephropathies showing inflammatory interstitial injury. In vitro, cultured human mesangial cells synthesized PTX3 when stimulated with TNF-α and IgA and exhibited specific binding for recombinant PTX3. Moreover, stimulation with exogenous PTX3 promoted mesangial cell contraction and synthesis of the proinflammatory lipid mediator platelet-activating factor. In conclusion, we provide the first evidence that mesangial cells may both produce and be a target for PTX3. The detection of this long pentraxin in the renal tissue of patients with glomerulonephritis suggests its potential role in the modulation of glomerular and tubular injury.

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“…It turned out that there was an association of plasma pentraxin 3 concentration and carotid atherosclerosis found in the control group of patients with cardiovascular complications but with normal glucose tolerance. In the group of patients with type 2 diabetes and cardiovascular complications we have found an association of plasma concentration of PTX3 is not only the early marker of irreversible cardiac damage, but can also predict its future course [8,9]. Moreover, Hudzik et al proved that PTX3 may be a potential early marker of cardiovascular risk before the increase of systemic markers like hsCRP [10].…”

Section: Introductionmentioning

confidence: 99%

Pentraxin 3 and atherosclerosis among type 2 diabetic patients

Nabrdalik¹,

Chodkowski

Bartman

et al. 2017

Open Life Sciences

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PTX3, A Prototypical Long Pentraxin, Is an Early Indicator of Acute Myocardial Infarction in Humans

Abstract: PTX3 is present in the intact myocardium, increases in the blood of patients with AMI, and disappears from damaged myocytes. We suggest that PTX3 is an early indicator of myocyte irreversible injury in ischemic cardiomyopathy.

Cited by 386 publications

References 30 publications

Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

Pentraxin-3 Predicts Functional Recovery and 1-Year Major Adverse Cardiovascular Events After Rehabilitation of Cardiac Surgery Patients

The Long Pentraxin Ptx3 Is Synthesized in IgA Glomerulonephritis and Activates Mesangial Cells

Pentraxin 3 and atherosclerosis among type 2 diabetic patients

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