PTH-98 Faecal Immunochemical Test, FAST score or NG12 criteria for detection of cancer

The performance of FIT-based and other risk prediction models for colorectal neoplasia in symptomatic patients: a systematic review

“…All included studies were of an observational study design, with 21 cross-sectional studies, 19 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 17 retrospective studies, 18 , 30 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 15 prospective studies, 39 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 and eight case–control studies. 62 , 75 , 76 , 77 , 78 , 79 , 80 One study design was unclear, as it was an abstract only.…”

“…Settings were primary care (n = 21), 30 , 31 , 35 , 47 , 50 , 51 , 52 , 53 , 54 , 56 , 59 , 62 , 64 , 66 , 68 , 71 , 73 , 77 , 78 , 80 primary and secondary care (n = 12), 18 , 19 , 30 , 33 , 34 , 49 , 60 , 63 , 65 , 67 , 72 secondary care (n = 24), 29 , 32 , 36 , 37 , 38 , 39 , 41 , 42 , 43 , 44 , 46 , 48 , 55 , 57 , 58 , 61 , 62 , 69 , 70 , 74 , 75 , 76 , 79 , 82 secondary and tertiary care (n = 3), 27 , 28 , 40 and tertiary care (n = 1). 45 One study was unclear regarding the setting.…”

“…81 Databases or registries were used in 17 studies. 30 , 47 , 48 , 50 , 51 , 52 , 53 , 54 , 56 , 60 , 77 , 78 , 79 , 80 , 82 , 83 , 84 …”

“…One study examined patients from two different countries: Scotland and Spain. 18 A further 24 studies assessed patients from the UK, 30 , 31 , 38 , 41 , 43 , 44 , 45 , 46 , 47 , 51 , 56 , 57 , 59 , 60 , 61 , 62 , 66 , 70 , 71 , 77 , 80 , 81 eight from Denmark, 35 , 39 , 48 , 69 , 74 , 76 , 79 , 82 seven from Spain, 19 , 30 , 34 , 40 , 49 , 63 , 65 five from the Netherlands, 50 , 52 , 53 , 54 , 64 five from Sweden, 67 , 68 , 78 , 83 , 84 four from Australia, 27 , 28 , 37 , 72 two from China, 32 , 55 one from the USA, 73 one from Canada, 42 one from New Zealand, 58 one from Egypt, 75 one from Italy, 36 one from Malaysia 33 and one from Nigeria. 29 For further...…”

“… Development CRC = 75 AA = 75 Validation CRC = 75 AA = 76 Boulind 2022 62 (UK) Prospective cohort Secondary Overall = 558 Model = unclear Three NHS trusts (Yeovil, North Bristol, and St James, Leeds); screened from consecutive fast track CRC referrals and approached when attending colonoscopy or review. (Aug 2018–Dec 2020) mean (range): 64 (18–89) Male = 311 Female = 247 NR Colonoscopy or CT CRC = 18 (5 suspected at CT) Polyp = 134 Cama 2021 30 (UK) Retrospective cohort Primary 3460 patients returned a FIT sample, 1046 underwent any investigation and 701 patients had full colonic evaluation–it is unclear who was used in the analysis Medical records (cross referenced with the trust cancer datanase); Herts Valley UK (June 2019–July 2020) Mean (IQR): 66 (56–76) Male = 43% Female = 57% NR Colonic investigation—undefined NR Collins 2012 47 (UK) Retrospective cohort Primary QResearch database (internal validation) = 1,236,601 THIN (external validation) Male = 417,560 (with imputation = 1,059,765) Female = 1,075,775 THIN database (external validation; 1st Jan 2000–30th June 2008) Mean (SD) QResearch database Development = 50.1 (15) Validation = 50.1 (14.9) THIN database Median (IQR) Male = 47 (38–60) Female = 49 (38–63) THIN database Male = 1,059,765 Female = 1,075,775 NR Identification via the THIN database records. THIN database CRC = 3712 Croner 2017 48 (Denmark) Retrospective cohort Secondary Overall = 4698 Development = 3099 Validation = 1336 Endoscopy II database samples, collected from seven hospitals across Denmark.…”