Pterygium: A Geographical Study

Detels, Roger; Dhir, Shalini

doi:10.1001/archopht.1967.00980030487014

Cited by 112 publications

(73 citation statements)

References 6 publications

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“…In our study, 80% of the cases were involved in outdoor activities, corroborating with the earlier studies [19,20].…”

Section: Occupation Incidencesupporting

confidence: 93%

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Tear and Pterygium: A Clinico-Pathological Study of Conjunctiva for Tear Film Anomaly in Pterygium

Onkar¹,

Pandey²,

Bist³

et al. 2017

J Eye Cataract Surg

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Aims: To evaluate the clinical and histological status of tear film in patients with unilateral pterygium. Settings and Design:Cross-sectional, case-control, doubleblinded study. Methods and Material:Cross-sectional study of both eyes of 102 patients with unilateral pterygium was conducted between March 2011 to December 2012. Patients were subject to fluorescein lower tear meniscus height (LTMH) evaluation, fluorescein tear break-up time (TBUT), Schirmer's test (using topical anesthetic), vital staining (viz. fluorescein, Rose Bengal and lissamine staining), LTMH imaging with anterior segment spectral-domain optical coherence tomography (OCT) cornea-anterior module (CAM-L and CAM-S), and conjunctival smear impression cytology. The normal eye acted as control. Statistical analysis used: fisher's t-test and chi-square test.Results: The study comprised of seventy males and thirtytwo females in the age-range 28-76years. The mean fluorescein LTMH, mean TBUT, mean Schirmer's test value, mean OCT CAM-S and CAM-L values in the normal control eyes were 0.36 ± 0.03 mm, 12.3 ± 1.9s, 13.4 ± 2.5 mm, 0.338 ± 0.082 mm and 0.325 ± 0.088 mm, respectively. The comparable values in eyes with pterygium were 0.24 ± 0.03 mm, 8.2 ± 1.4 sec, 9.2 ± 2.4 mm, 0.212 ± 0.046 mm and 0.204 ± 0.058 mm respectively. Goblet cell count was decreased in impression cytology. Conclusions:Both fluorescein and OCT LTMH were found to be significantly decreased (p<0.01) in eyes with pterygium compared to control eyes. Goblet cell count, TBUT and Schirmer's test values were also comparatively decreased. This study thus emphasizes that tear film abnormalities play a role in aetiology of pterygium and hence early institution of therapy for tear film stabilization can help prevent the disease. Keywords: Keymessage:This study emphasizes that tear film abnormalities play a role in aetiology of pterygium and hence early institution of therapy for tear film stabilization can help prevent the disease.

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“…In our study, 80% of the cases were involved in outdoor activities, corroborating with the earlier studies [19,20].…”

Section: Occupation Incidencesupporting

confidence: 93%

“…A universal conclusion from all the studies conducted in India and abroad is that pterygium is seen more commonly in males than females [17][18][19][20]. In our study, 68 males and 32 females had pterygium giving a male/female ratio of approximately 2.2.…”

Section: Sex Incidencesupporting

confidence: 52%

Tear and Pterygium: A Clinico-Pathological Study of Conjunctiva for Tear Film Anomaly in Pterygium

Onkar¹,

Pandey²,

Bist³

et al. 2017

J Eye Cataract Surg

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“…1 Thus, it is more commonly seen among outdoor workers in tropical countries. 2 Pterygium may be responsible for disturbance of vision by its astigmatic effect or by growing so large as to occlude the visual axis. It could also be a cause of much ocular irritation as well as being cosmetically unacceptable for many people especially when fleshy or inflamed.…”

Section: Introductionmentioning

confidence: 99%

Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft

Bekibele

Baiyeroju

Olusanya

et al. 2006

Eye

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Background The use of conjunctiva autograft, adjunct antimetabolite therapy has been shown to be effective in preventing pterygium recurrence. Objective To compare 5 fluorouracil (5-FU) to conjunctival autograft in the treatment of large, fleshy pterygium. Methods A randomised controlled prospective study of outcome of pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft. Thirty-five eyes with large pterygium treated with bare sclera conjunctival excision plus 5-FU were compared with 33 eyes treated with excision and conjunctival autograft alone. Results Post-operative pterygium recurrence was observed in four (11.4%) eyes treated with 5-FU and 4 (12.1%) eyes treated with conjunctiva autograft (P40.05). The post-operative complications included, granuloma formation 11.4% for 5-FU and 3.0% for autograft and conjunctival discharge 5.7% for 5-FU group only. Conclusion 5-FU is marginally superior to conjunctival autograft in the prevention of pterygium recurrence but neither gives a more desirable single digit recurrence rate. Randomised studies combining both conjunctival autograft and 5-FU in pterygium treatment is advocated to further explore their effect.

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“…The prevalence of this disorder enhanced in some special populations, such as farmers, fishermen, and people living in dry, sunny clients, etc. 1 Although the aetiology of pterygium is still not fully understood, prolonged exposure to ultraviolet B radiation is thought to promote its development. 2,3 Other factors such as inherited susceptibility, 4 chronic inflammation, 5 heat, 6 and still others may also play a role in the formation of pterygium.…”

Section: Introductionmentioning

confidence: 99%

Tear function and goblet cell density after pterygium excision

Zhang

Lin

et al. 2005

Eye

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Purpose To evaluate the short-term effect of pterygium excision on tear function and conjunctival goblet cell density. Methods In all, 70 patients (70 eyes) with primary pterygia who underwent a bare-sclera procedure were enrolled in this study. Tear break-up time, Schirmer, and tear-ferning tests and conjunctival goblet cell density obtained by impression cytology were evaluated before and 1 month after surgery. Results At 1 month postoperation, the tear break-up time (11.4973.76 s) was significantly prolonged when compared with the preoperation tear break-up time (9.7473.43 s, P ¼ 0.002). Before surgery, only 17% of the patients showed normal crystallization in the tear-ferning test. This proportion was significantly increased to 90% 1 month after surgery (Po0.001). There is no significant difference in the Schirmer test value between pre-and postsurgery (P40.05). The mean goblet cell density in conjunctival impression specimens before surgery was 41.82718.29/10 fields, which was increased significantly 1 month after surgery (Po0.001) with a mean cell density of 50.67718.71/10 fields. Conclusion Tear function in patients with primary pterygium improves after pterygium excision, which indicates that pterygium has a close relationship with dry eye.

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Pterygium: A Geographical Study

Cited by 112 publications

References 6 publications

Tear and Pterygium: A Clinico-Pathological Study of Conjunctiva for Tear Film Anomaly in Pterygium

Tear and Pterygium: A Clinico-Pathological Study of Conjunctiva for Tear Film Anomaly in Pterygium

Pterygium treatment using 5-FU as adjuvant treatment compared to conjunctiva autograft

Tear function and goblet cell density after pterygium excision

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