Pterostilbene Reduced Post-Antibiotic Effect Time of Linezolid against Methicillin-Resistant Staphylococcus aureus

Basri, Dayang Fredalina; Hamid, Nasri A.; Ishak, Siti Fairuz; Ghazali, Ahmad Rohi

doi:10.4172/pharmaceutical-sciences.1000179

Cited by 1 publication

(1 citation statement)

References 30 publications

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“…Great attention is currently paid to the combinations of different natural substances and antibiotics, and the results show a significant reduction in effective antibiotic concentrations [63]. Natural substances are also effective against multi-resistant strains, such as Pseudomonas aeruginosa or MRSA [64][65][66]. Another study tested the effectiveness of salvipisone and aethiopinone against MRSA strains.…”

Section: Resultsmentioning

confidence: 99%

Boswellic Acids as Effective Antibacterial Antibiofilm Agents

et al. 2022

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Boswellic acids are biologically active pentacyclic terpenoid compounds derived from Boswellia sp. plants. Extracts containing these acids have a number of positive effects on human health, especially in the treatment of inflammation, arthritis, or asthma. With increasing resistance to common antibiotics, boswellic acid-containing extracts could serve as an alternative or work in synergy with commonly available preparations. This study aims to determine the effect of boswellic acids on suspension cells and biofilms of Staphylococcus epidermidis, Enterococcus faecalis, and Escherichia coli. The antimicrobial and antibiofilm effect found was compared with commonly available antibiotics to control these undesirable microorganisms. The synergistic effect of boswellic acids and common antibiotics on the growth of these microorganisms was also determined. All tested microorganisms showed a positive additive effect of antibiotics and boswellic acid extract. The most significant effect was found in Enterococcus faecalis ATCC 29212 in a combination of 0.2 × MIC80 erythromycin (0.2 mg/L) and 0.8 × MIC80 boswellic acid extract (16 mg/L).

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