Psychotic reactions to daily life stress and dopamine function in people with severe hearing impairment

Gevonden, Martin; Myin-Germeys, Inez; Brink, Wim van den; Os, Jim van; Selten, Jean Paul; Booij, Jan

doi:10.1017/s0033291714002797

Cited by 16 publications

(16 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Geographical momentary assessment studies that allow for real-time tracking and linkage of neighbourhood surroundings with subjective ratings of these 84 , 85 are now needed to elucidate further the interplay of psychological mechanisms and area-level socio-environmental exposures. Similarly, the finding that elevated sensitivity to outsider status is associated with psychotic experiences, though in line with previous research, 34 needs to be further validated in the context of socio-environmental factors that may increase sensitivity to this form of social stress.…”

Section: Discussionsupporting

confidence: 69%

See 1 more Smart Citation

Stress Sensitivity, Aberrant Salience, and Threat Anticipation in Early Psychosis: An Experience Sampling Study

Reininghaus

Kempton

Valmaggia

et al. 2016

SCHBUL

242

243

View full text Add to dashboard Cite

While contemporary models of psychosis have proposed a number of putative psychological mechanisms, how these impact on individuals to increase intensity of psychotic experiences in real life, outside the research laboratory, remains unclear. We aimed to investigate whether elevated stress sensitivity, experiences of aberrant novelty and salience, and enhanced anticipation of threat contribute to the development of psychotic experiences in daily life. We used the experience sampling method (ESM) to assess stress, negative affect, aberrant salience, threat anticipation, and psychotic experiences in 51 individuals with first-episode psychosis (FEP), 46 individuals with an at-risk mental state (ARMS) for psychosis, and 53 controls with no personal or family history of psychosis. Linear mixed models were used to account for the multilevel structure of ESM data. In all 3 groups, elevated stress sensitivity, aberrant salience, and enhanced threat anticipation were associated with an increased intensity of psychotic experiences. However, elevated sensitivity to minor stressful events (χ2 = 6.3, P = 0.044), activities (χ2 = 6.7, P = 0.036), and areas (χ2 = 9.4, P = 0.009) and enhanced threat anticipation (χ2 = 9.3, P = 0.009) were associated with more intense psychotic experiences in FEP individuals than controls. Sensitivity to outsider status (χ2 = 5.7, P = 0.058) and aberrantly salient experiences (χ2 = 12.3, P = 0.002) were more strongly associated with psychotic experiences in ARMS individuals than controls. Our findings suggest that stress sensitivity, aberrant salience, and threat anticipation are important psychological processes in the development of psychotic experiences in daily life in the early stages of the disorder.

show abstract

Section: Discussionsupporting

confidence: 69%

“…Further, exposure to socio-environmental factors (eg, social disadvantage, 30–33 ethnic minority status 10 , 11 ) may sensitize, and increase emotional reactivity of, individuals to subjective experiences of outsider status, and so increase intensity of psychotic experiences in daily life. 10 , 34 …”

Section: Introductionmentioning

confidence: 99%

Stress Sensitivity, Aberrant Salience, and Threat Anticipation in Early Psychosis: An Experience Sampling Study

Reininghaus

Kempton

Valmaggia

et al. 2016

SCHBUL

242

243

View full text Add to dashboard Cite

show abstract

“…Recently, young adults with severe hearing impairment showed higher baseline feelings of social defeat and loneliness, a higher stressinduced dopamine release and a stronger association between social stress and momentary psychotic experiences, when compared with normal hearing controls (Gevonden et al, 2015(Gevonden et al, , 2014.…”

Section: Social Isolationmentioning

confidence: 99%

Increased risk of psychosis in patients with hearing impairment: Review and meta-analyses

Linszen

Brouwer

Heringa

et al. 2016

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

“…Childhood trauma may increase sensitivity not only to minor stressful events but also to more minor adverse social contexts and experiences later in daily life, including distinctive unpleasant social situations (referred to here as ‘social stress’) (Myin-Germeys et al 2001; Morgan et al 2014), subjective experiences of outsider status (as one specific, potentially relevant form of social stress) (Morgan & Fisher, 2007; Morgan et al 2010; Gevonden et al 2015), and unpleasant neighbourhoods (referred to here as ‘area-related stress’) (Jaffee et al 2007; Kirkbride et al 2014). Further, exposure to adverse and threatening experiences during childhood may lead individuals to anticipate more unpleasant events and threat from their environment to create an enduring sense of threat anticipation (Morgan et al 2010; Bentall et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Psychological processes underlying the association between childhood trauma and psychosis in daily life: an experience sampling study

et al. 2016

Self Cite

View full text Add to dashboard Cite

BackgroundEvidence has accumulated that implicates childhood trauma in the aetiology of psychosis, but our understanding of the putative psychological processes and mechanisms through which childhood trauma impacts on individuals and contributes to the development of psychosis remains limited. We aimed to investigate whether stress sensitivity and threat anticipation underlie the association between childhood abuse and psychosis.MethodWe used the Experience Sampling Method to measure stress, threat anticipation, negative affect, and psychotic experiences in 50 first-episode psychosis (FEP) patients, 44 At-Risk Mental State (ARMS) participants, and 52 controls. Childhood abuse was assessed using the Childhood Trauma Questionnaire.ResultsAssociations of minor socio-environmental stress in daily life with negative affect and psychotic experiences were modified by sexual abuse and group (all pFWE < 0.05). While there was strong evidence that these associations were greater in FEP exposed to high levels of sexual abuse, and some evidence of greater associations in ARMS exposed to high levels of sexual abuse, controls exposed to high levels of sexual abuse were more resilient and reported less intense negative emotional reactions to socio-environmental stress. A similar pattern was evident for threat anticipation.ConclusionsElevated sensitivity and lack of resilience to socio-environmental stress and enhanced threat anticipation in daily life may be important psychological processes underlying the association between childhood sexual abuse and psychosis.

show abstract

Psychotic reactions to daily life stress and dopamine function in people with severe hearing impairment

Cited by 16 publications

References 55 publications

Stress Sensitivity, Aberrant Salience, and Threat Anticipation in Early Psychosis: An Experience Sampling Study

Stress Sensitivity, Aberrant Salience, and Threat Anticipation in Early Psychosis: An Experience Sampling Study

Increased risk of psychosis in patients with hearing impairment: Review and meta-analyses

Psychological processes underlying the association between childhood trauma and psychosis in daily life: an experience sampling study

Contact Info

Product

Resources

About