Psychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: an item response theory analysis

Laurens, Kristin R.; Hobbs, Megan J.; Sunderland, Matthew; Green, Melissa; Mould, Glenn L.

doi:10.1017/s0033291711002108

Cited by 149 publications

(187 citation statements)

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“…Subclinical psychotic symptoms or psychotic-like experiences (PLEs) in childhood and adolescence are associated with concurrent emotional and behavioural difficulties (Laurens et al, 2007(Laurens et al, , 2012Nishida et al, 2008;Scott et al, 2009;Armando et al, 2010;Bartels-Velthuis et al, 2010;Polanczyk et al, 2010;Barragan et al, 2011;Kelleher et al, 2012b). PLEs that persist into adulthood increase risk for social dysfunction (Rossler et al, 2007), affective disturbance (van Rossum et al, 2011), substance misuse (Dhossche et al, 2002), and psychotic disorder .…”

Section: Introductionmentioning

confidence: 99%

“…PLEs prior to adolescence may constitute part of a spectrum of normative development (Laurens et al, 2012). Longitudinal studies following adolescents into adulthood distinguish short-lived or transitory PLEs that may be relatively benign from persistent PLEs that impose a greater likelihood of concurrent, and later, psychiatric morbidity and social impairment (Cougnard et al, 2007;Woods et al, 2009;Dominguez et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

“…Firstly, most studies have measured PLEs only from early-mid adolescence, despite growing evidence that children as young as eight years old can give a reliable and valid account of these experiences (Laurens et al, 2007(Laurens et al, , 2012Bartels-Velthuis et al, 2010). Schizophrenia Research 144 (2013) Contents lists available at SciVerse ScienceDirect Schizophrenia Research j o u r n a l h o m e p a g e : w w w .…”

Section: Introductionmentioning

confidence: 99%

“…Lastly, longitudinal population-based studies have focused typically on the relationship between PLEs and internalising problems only. Externalising problems also warrant examination, as there is heterotypic (cross-disorder) continuity between externalising and internalising disorders (Costello et al, 2003), and cross-sectional studies indicate that PLEs are associated with externalising problems (Laurens et al, 2007(Laurens et al, , 2012Kinoshita et al, 2011;Kelleher et al, 2012b).…”

Section: Introductionmentioning

confidence: 99%

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Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

Downs

Cullen

Barragán

et al. 2013

Schizophrenia Research

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Downs, J. (2013). Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort. Schizophrenia Research, 144(1-3), 99-104. https://doi.org/10.1016/j.schres.2012.12.009Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. Background: Persisting psychotic-like experiences (PLEs) are associated with an increased risk of internalising symptoms in adolescence. Whether this association holds similarly for externalising symptoms, and from mid-childhood, is unclear. This prospective study investigated the extent to which PLE persistence was associated with internalising and externalising psychopathology in a community sample of children aged 9-11 years at study commencement. Methods: 8099 children (mean age 10.4 years) completed questionnaires assessing PLEs, externalising and internalising symptoms. A subsample of 547 children completed reassessment, on average, two years later. Results: Two-thirds (66%) of children reported PLEs at baseline. Approximately two years later, PLEs persisted in 39% of those children. After adjustment for previous psychopathology and other potential confounds, children with persisting PLEs were at higher risk for internalising (odds ratio [OR]=1.94; 95% confidence interval [CI] 1.13-3.34) and externalising (OR=1.97; 95% CI 1.19-3.26) psychopathology than children whose PLEs remitted; and, than children who never presented PLEs. Conclusions: Persistent PLEs from mid-childhood are associated with later internalising and externalising psychopathology in the general population, whereas transitory PLEs may be part of a spectrum of normative childhood development. Interventions that target persistent PLEs may contribute to a reduction in common chi...

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

Downs

Cullen

Barragán

et al. 2013

Schizophrenia Research

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“…Much research has established that psychotic experiences have a higher prevalence in the general population than psychotic disorders [1][2][3][4]. A meta-analysis of all community studies of psychotic experiences in children and adolescents found a median population prevalence of 17% in children aged 9-12 years and 7.5% in those aged 13-18 years [5].…”

Section: Introductionmentioning

confidence: 99%

Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Ramsay¹,

Kelleher²,

Flannery³

et al. 2015

Holistic Perspectives on Trauma

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Objective: Psychotic experiences occur at a much greater prevalence in the population than psychotic disorders. There has been little research to date, however, on genetic risk for this extended psychosis phenotype. We examined whether COMT or BDNF genotypes were associated with psychotic experiences or interacted with childhood trauma in predicting psychotic experiences.Method: Psychiatric interviews and genotyping for COMT-Val158Met and BDNF-Val66Met were carried out on two population-based samples of 237 individuals aged 11-15 years. Logistic regression was used to examine for main effects by genotype and childhood trauma, controlling for important covariates. This was then compared to a model with a term for interaction between genotype and childhood trauma. Where a possible interaction was detected, this was further explored in stratified analyses. Results:While childhood trauma showed a borderline association with psychotic experiences, COMT-Val158Met and BDNF-Val66Met genotypes were not directly associated with psychotic experiences in the population. Testing for gene x environment interaction was borderline significant in the case of COMT-Val158Met with individuals with the COMT-Val158Met Val-Val genotype, who had been exposed to childhood trauma borderline significantly more likely to report psychotic experiences than those with Val-Met or Met-Met genotypes. There was no similar interaction by BDNF-Val66Met genotype. Conclusion:The COMT-Val158Met Val-Val genotype may be a genetic moderator of risk for psychotic experiences in individuals exposed to childhood traumatic experiences.

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Psychotic Symptoms and Population Risk for Suicide Attempt

Kelleher¹,

Corcoran²,

Keeley³

et al. 2013

JAMA Psychiatry

222

180

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Psychotic-like experiences in a community sample of 8000 children aged 9 to 11 years: an item response theory analysis

Cited by 149 publications

References 47 publications

Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

Relationship between the COMT-Val158Met and BDNF-Val66Met Polymorphisms, Childhood Trauma and Psychotic Experiences in an Adolescent General Population Sample

Psychotic Symptoms and Population Risk for Suicide Attempt

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