Psychosocial Outcomes for Children With Nonalcoholic Fatty Liver Disease Over Time and Compared With Obese Controls

Kerkar, Nanda; D’Urso, Christine; Nostrand, Kelsey Van; Kochin, Israel; Gault, Allison; Suchy, Frederick J.; Miloh, Tamir; Arnon, Ronen; Chu, Jaime; Annunziato, Rachel A.

doi:10.1097/mpg.0b013e31826f2b8c

Cited by 35 publications

(52 citation statements)

References 15 publications

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“…[24] There is also growing evidence that children and adolescents with NAFLD have a higher rate of psychological distress compared with healthy or obese controls. [25,26] Furthermore, in the present research, occupational stress was demonstrated to be a risk factor for NAFLD among Chinese police officers.…”

Section: Discussionsupporting

confidence: 54%

Increased risk of nonalcoholic fatty liver disease with occupational stress in Chinese policemen

Xing

Shan

et al. 2016

Medicine

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Nonalcoholic fatty liver disease (NAFLD) and occupational stress have been recognized as major public health concerns. We aimed to explore whether occupational stress was associated with NAFLD in a police population.A total of 6559 male police officers were recruited for this prospective study in April 2007. Among them, 2367 eligible subjects participated in follow-up from 2008 to 2011. NAFLD was diagnosed based on standard criteria. Occupational stress was evaluated by Occupational Stress Inventory-Revised scores.The incidence of NAFLD was 31.2% in the entire police. After adjusting for traditional risk factors, moderate occupational stress (MOS), high occupational stress (HOS), and high personal strain (HPS) were risk factors (MOS: hazard ratio [HR] = 1.237, 95% confidence interval [CI] = 1.049–1.460; HOS: HR = 1.727, 95% CI = 1.405–2.124; HPS: HR = 3.602, 95% CI = 1.912–6.787); and low occupational stress (LOS) and low personal strain (LPS) were protective factors (LOS: HR = 0.366, 95% CI = 0.173–0.776; LPS: HR = 0.490, 95% CI = 0.262–0.919) for NAFLD in the entire police cohort. HOS and HPS remained robust among traffic police.HOS and HPS were independent predictors for the development of NAFLD in a Chinese police population. Additional future prospective investigations are warranted to validate our findings.

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Section: Discussionsupporting

confidence: 54%

Increased risk of nonalcoholic fatty liver disease with occupational stress in Chinese policemen

Xing

Shan

et al. 2016

Medicine

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“…Another study on 48 children and adolescents with NAFLD between 8 and 18 years found higher levels of depression compared to obese children and adolescents without NAFLD. 102 In addition, more frequent emotional and behavioral problems have been noted in children with NAFLD compared to healthy controls. 97 There are important questions that remain regarding how much the psychosocial problems observed are due to NAFLD itself versus the role of obesity and/or other unmeasured factors.…”

Section: Associated Co-morbidities Of Nafldmentioning

confidence: 99%

Comparison of the Phenotype and Approach to Pediatric vs Adult Patients With Nonalcoholic Fatty Liver Disease

et al. 2016

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Nonalcoholic fatty liver disease (NAFLD) is one of the main chronic non-communicable diseases in westernized societies; its worldwide prevalence has doubled during the last 20 years. NAFLD has serious health implications not only for adults, but also for children. However, pediatric NAFLD is not only an important global problem in itself, but it is likely to be associated with increases in comorbidities such as metabolic syndrome and cardiovascular diseases. There are several differences between NAFLD in children and adults and it is not clear whether the disease observed in children is the initial phase of a process that progresses with age. The increasing prevalence of pediatric NAFLD has serious implications for the future adult population requiring appropriate action. Studies of NAFLD progression, pathogenesis, and management should evaluate disease phenotypes in children and follow these over patient lifetimes. We review the similarities and differences of NAFLD between children and adults.

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“…Fatigue, trouble sleeping, and sadness were the symptoms that accounted for nearly half of the variance in quality of life scores compared to controls [24]. In a study of psychosocial outcomes in children with NAFLD, children with NAFLD had higher levels of depression compared to obese controls [25]. Children with NAFLD may have a substantial psychological burden and disease management should take potential psychosocial co-morbidities into account to provide patient-centered care.…”

Section: Introductionmentioning

confidence: 99%

The Progression and Natural History of Pediatric Nonalcoholic Fatty Liver Disease

Goyal

Schwimmer

2016

Clinics in Liver Disease

129

115

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States. Childhood NAFLD is associated with hepatic and non-hepatic morbidity and mortality. Non-hepatic associations included cardiovascular, metabolic, pulmonary and psychological disorders. Cardiovascular conditions observed in childhood include left ventricular dysfunction. Furthermore, childhood obesity is associated with greater odds of having hepatocellular carcinoma as an adult. Evidence suggests that NAFLD may begin in utero in children of diabetic mothers. However, NAFLD typically is diagnosed between the ages of 10–13 years. The actual onset of disease for most children is not known. At diagnosis 10–25% of children can have advanced fibrosis. In the most severe cases, children can progress within a few years to cirrhosis and end-stage liver disease. Quality longitudinal data of the natural history of pediatric NAFLD are limited. Available data suggest that children with NAFLD are at risk for higher mortality rates as young adults. However, NAFLD is a heterogeneous disease and natural history is expected to vary considerably from child to child. Thus rigorous efforts for structured diagnosis and follow-up are a priority to better develop the understanding of outcomes in pediatric NAFLD needed to provide accurate counseling to children and their families.

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Psychosocial Outcomes for Children With Nonalcoholic Fatty Liver Disease Over Time and Compared With Obese Controls

Abstract: Children with NAFLD have higher levels of depression than obese controls. Outcomes did not improve with standard care. Larger longitudinal studies and appropriate interventions are required in this area.

Cited by 35 publications

References 15 publications

Increased risk of nonalcoholic fatty liver disease with occupational stress in Chinese policemen

Increased risk of nonalcoholic fatty liver disease with occupational stress in Chinese policemen

Comparison of the Phenotype and Approach to Pediatric vs Adult Patients With Nonalcoholic Fatty Liver Disease

The Progression and Natural History of Pediatric Nonalcoholic Fatty Liver Disease

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