Psychophysical effects of an exercise therapy during pediatric stem cell transplantation: a randomized controlled trial

Senn-Malashonak, Anna; Wallek, Susanne; Schmidt, Katharina; Rosenhagen, Andreas; Vogt, Lutz; Bader, Peter; Banzer, Winfried

doi:10.1038/s41409-019-0535-z

Cited by 24 publications

(62 citation statements)

References 42 publications

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“…There is biological rationale to support that physical exercise interventions might help to lessen some of the side effects of pediatric HSCT. Previous findings support the feasibility of this type of intervention in children/adolescents undergoing HSCT, as it does not compromise the recovery of immune cells [ 9 ] and at the same time improves physical function [ 12 , 13 ]. Further, recent meta-analytic evidence indicates that physical exercise attenuates the functional decline of children and adolescents with cancer in general [ 4 ], and particularly in HSCT recipients [ 5 ], with functional decline being an often observed adverse effect in the context of pediatric cancer [ 14 ].…”

Section: Discussionmentioning

confidence: 77%

Tailored Exercise during Hematopoietic Stem Cell Transplantation Hospitalization in Children with Cancer: A Prospective Cohort Study

Morales

Vicent

Castillo‐García³

et al. 2020

Cancers

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Section: Discussionmentioning

confidence: 77%

Tailored Exercise during Hematopoietic Stem Cell Transplantation Hospitalization in Children with Cancer: A Prospective Cohort Study

Morales

Vicent

Castillo‐García³

et al. 2020

Cancers

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“…Senn-Malashonak et al. ( 31 ) and Morales et al., 2020b ( 30 ) reported no differences in transplantation outcomes such as complications or GvHD for children undergoing HSCT. The effects on physical and/or functional performance as well as body composition have been reviewed in other studies in depth ( 13 , 14 , 35 ).…”

Section: Resultsmentioning

confidence: 97%

“…Detailed study characterizations are available in Table 1 . Risk of bias assessment could be performed for the three RCTs and studies scored with 4 out of 10 ( 32 ), 6 out of 10 ( 29 ), and 5 out of 10 ( 31 ) possible points (see Supplement 3 ).…”

Section: Resultsmentioning

confidence: 99%

“…Most studies focused on mixed interventions with strength and aerobic exercises. In the study of Chamorro-Vina et al ( 28 ), Morales et al ( 30 ) and Senn-Malashonak et al ( 31 ) participants attended a supervised in-hospital exercise program five times per week for about three weeks until discharge during HSCT. In Chamorro-Vina et al ( 29 ) children performed three times per week a supervised in-hospital & home-based training after discharge of HSCT for ten weeks.…”

Section: Resultsmentioning

confidence: 99%

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Effects of Exercise Interventions on Immune Function in Children and Adolescents With Cancer and HSCT Recipients - A Systematic Review

2021

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BackgroundPediatric cancer patients are at high risk for life-threatening infections, therapy associated complications and cancer-related side effects. Exercise is a promising tool to support the immune system and reduce inflammation. The primary objective of this systematic review was to evaluate the effects of exercise interventions in pediatric cancer patients and survivors on the immune system.MethodsFor this systematic review (PROSPERO ID: CRD42021194282) we searched four databases (MEDLINE, Cochrane Library, ClinicalTrials.gov, SPORTDiscus) in June 2021. Studies with pediatric patients with oncological disease were included as main criterion. Two authors independently performed data extraction, risk of bias assessment, descriptive analysis and a direction ratio was calculated for all immune cell parameters.FindingsOf the 1448 detected articles, eight studies with overall n = 400 children and adolescents with cancer and n = 17 healthy children as controls aged 4-19 years met the inclusion criteria. Three randomized, four non-randomized controlled trials and one case series were analyzed descriptively. The exercise interventions had no negative adverse effects on the immune system. Statistically significant results indicated enhanced cytotoxicity through exercise, while changes in immune cell numbers did not differ significantly. Interventions further reduced days of in-hospitalization and reduced the risk of infections. Several beneficial direction ratios in immune parameters were identified favoring the intervention group.InterpretationExercise interventions for pediatric cancer patients and survivors had no negative but promising beneficial effects on the immune system, especially regarding cytotoxicity, but data is very limited. Further research should be conducted on the immunological effects of different training modalities and intensities, during various treatment phases, and for different pediatric cancer types. The direction ratio parameters given here may provide useful guidance for future clinical trials.Systemic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021194282, Prospero ID: CRD42021194282.

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“…There are positive intervention effects for body composition, flexibility, cardiorespiratory fitness, muscle strength, and health-related QoL (cancer-related items) 22,[33][34][35][36][37] . Also, patients undergoing a HSCT can benefit from adapted training [38][39][40] .…”

mentioning

confidence: 99%

Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies

Lanfranconi

Zardo

Moriggi

et al. 2020

Sci Rep

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children and adolescents with haematological malignancies (pedHM) are characterized by a severe loss of exercise ability during cancer treatment, lasting throughout their lives once healed and impacting their social inclusion prospects. The investigation of the effect of a precision-based exercise program on the connections between systems of the body in pedHM patients is the new frontier in clinical exercise physiology. This study is aimed at evaluating the effects of 11 weeks (3 times weekly) of combined training (cardiorespiratory, resistance, balance and flexibility) on the exercise intolerance in PedHM patients. Two-hundred twenty-six PedHM patients were recruited (47% F). High or medium frequency participation (HAd and MAd) was considered when a participant joined; > 65% or between 30% and < 64% of training sessions, respectively. The "up and down stairs'' test (TUDS), "6 min walking" test (6MWT), the "5 Repetition Maximum strength" leg extension and arm lateral raise test (5RM-LE and 5RM-ALR), flexibility (stand and reach), and balance (stabilometry), were performed and evaluated before and after training. The TUDS, the 5RM-LE and 5RM-ALR, and the flexibility exercises showed an increase in HAd and MAd groups (P < 0.05), while the 6MWT and balance tests showed improvement only in HAd group (P < 0.0001). these results support the ever-growing theory that, in the case of the treatment of PedHM, 'exercise is medicine' and it has the potential to increase the patient's chances of social inclusion.

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Psychophysical effects of an exercise therapy during pediatric stem cell transplantation: a randomized controlled trial

Cited by 24 publications

References 42 publications

Tailored Exercise during Hematopoietic Stem Cell Transplantation Hospitalization in Children with Cancer: A Prospective Cohort Study

Tailored Exercise during Hematopoietic Stem Cell Transplantation Hospitalization in Children with Cancer: A Prospective Cohort Study

Effects of Exercise Interventions on Immune Function in Children and Adolescents With Cancer and HSCT Recipients - A Systematic Review

Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies

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