Psychopharmacological Signatures in the Retina in Schizophrenia and Bipolar Disorder: An Optic Coherence Tomography Study

Altun, İlkay Keleş; Turedi, Neslihan; Aras, Neriman; Atagün, Murat İlhan

doi:10.24869/psyd.2020.351

Cited by 9 publications

(2 citation statements)

References 31 publications

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“…Two studies (Altun et al 2020;Koman-Wierdak et al 2021) directly compared RNFL thickness between patients with SCZ and BD. 188 eyes of patients with SCZ and 216 eyes of patients with BD were compared.…”

Section: Peripapillary Rnfl Thicknessmentioning

confidence: 99%

“…In SCZ, there was a negative correlation between antipsychotic dose and nasal RNFL (Altun et al 2020), but no difference was found in RNFL thickness between those on First Generation Antipsychotics (FGAs) and Second Generation Antipsychotics (SGAs) (Altun et al 2020). In MDD, the duration of SSRI use was correlated with a reduction in parafoveal GCC and foveal thickness (Guclu et al 2018).…”

Section: Relationship With Psychotropicsmentioning

confidence: 99%

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A systematic review and meta-analysis of optical coherence tomography studies in schizophrenia, bipolar disorder and major depressive disorder

Prasannakumar

Kumar

Mailankody

et al. 2023

The World Journal of Biological Psychiatry

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Objectives: Due to the common neurodevelopmental origin and easy accessibility, the retina serves as a surrogate marker for changes in the brain. Hence, Optical Coherence Tomography (OCT), a tool to examine the neuronal layers of retina has gained importance in investigating psychiatric disorders. Several studies in the last decade have reported retinal structural alterations in schizophrenia (SCZ), bipolar disorder (BD), and major depressive disorder (MDD). However, the findings are inconsistent. Hence, we conducted a meta-analysis to investigate alterations in OCT parameters in patients with SCZ, BD and MDD. Methods: We searched electronic databases for studies that examined OCT parameters in patients with SCZ, BD and MDD published up to January 2023. The primary outcome measures were thickness and volumes of the retinal Nerve Fibre Layer (RNFL). We conducted meta-analysis using a random effects model. Results: The searches yielded 2638 publications of which 43 studies were included in the final analysis across all disorders. Compared to controls, the RNFL was thinner in SCZ patients (SMD ¼ À0.37, p ¼ <0.001) and BD patients (SMD ¼ À0.67, p ¼ < 0.001), but not in MDD patients (SMD ¼ À0.08, p ¼ 0.54). On quadrant wise analysis, temporal quadrant RNFL was thinner in SCZ but not in BD, while all other quadrants were thinner in both SCZ and BD. Conclusion: We found significant reductions in RNFL thickness in SCZ and BD, but not in MDD. The differential involvement in various quadrants and parameters across the disorders has potential implications for using retinal parameters as a diagnostic biomarker.

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Section: Peripapillary Rnfl Thicknessmentioning

confidence: 99%