Psychoneuroimmunology and trauma.

Dougall, Angela Liegey; Baum, Andrew

doi:10.1037/10723-006

Cited by 17 publications

(8 citation statements)

References 118 publications

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“…Stress increases the peripheral lymphocytes (natural killer [NK] cells and cytotoxic T cells) during exposure to the stressor; then those immune cells decrease to below baseline levels following the stressor (Breznitz et al, 1998; Delahanty, Wang, Maravich, Forlenza, & Baum, 2000; Dougall & Baum, 2004). Thus, with chronic stress (similar to what is seen in PTSD), the immune system has a blunted response to any new acute stressors (Baum, Cohen, & Hall, 1993; Dougall & Baum, 2004). For example, T cells do not immediately proliferate following an immediate stressor when exposed to chronic stress.…”

Section: Potential Mechanisms For How Trauma Affects Healthmentioning

confidence: 99%

Physical Health Problems After Single Trauma Exposure

D’Andrea

Sharma

Zelechoski

et al. 2011

J Am Psychiatr Nurses Assoc

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Research has established that chronic stress, including traumatic events, leads to adverse health outcomes. The literature has primarily used two approaches: examining the effect of acute stress in a laboratory setting and examining the link between chronic stress and negative health outcomes. However, the potential health impact of a single or acute traumatic event is less clear. The goal of this literature review is to extend the literature linking both chronic trauma exposure and posttraumatic stress disorder to adverse health outcomes by examining current literature suggesting that a single trauma may also have negative consequences for physical health. The authors review studies on health, including cardiovascular, immune, gastrointestinal, neurohormonal, and musculoskeletal outcomes; describe potential pathways through which single, acute trauma exposure could adversely affect health; and consider research and clinical implications.

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Section: Potential Mechanisms For How Trauma Affects Healthmentioning

confidence: 99%

Physical Health Problems After Single Trauma Exposure

D’Andrea

Sharma

Zelechoski

et al. 2011

J Am Psychiatr Nurses Assoc

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“…The physical consequences may be acute or develop into a chronic syndrome (Resnick, Acierno, & Kilpatrick, 1997). Negative physical effects may be gross (bruises, broken bones) or less obvious yet still significant, such as impaired immune functioning (Dougall & Baum, 2004) or increased allostatic load (Friedman & McEwan, 2004). In addition, abuse may have an impact on health via less direct pathways.…”

Section: Interpersonal Violence and Healthmentioning

confidence: 99%

Mental health pathways from interpersonal violence to health-related outcomes in HIV-positive sexual minority men.

Pantalone¹,

Hessler²,

Simoni³

2010

Journal of Consulting and Clinical Psychology

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Objective We examined mental health pathways between interpersonal violence (IPV) and health-related outcomes in HIV-positive sexual minority men engaged with medical care. Method HIV-positive gay and bisexual men (N = 178) were recruited for this cross-sectional study from 2 public HIV primary care clinics that treated outpatients in an urban setting. Participants (M age = 44.1 years, 36% non-White) filled out a computer-assisted survey and had health-related data extracted from their electronic medical records. We used structural equation modeling to test associations among the latent factors of adult abuse and partner violence (each comprising indicators of physical, sexual, and psychological abuse) and the measured variables: viral load, health-related quality of life (HRQOL), HIV medication adherence, and emergency room (ER) visits. Mediation was tested for the latent construct mental health problems, comprising depression, anxiety, symptomatology of posttraumatic stress disorder, and suicidal ideation. Results The final model demonstrated acceptable fit, χ2(123) = 157.05, p = .02, CFI = .95, TLI = .94, RMSEA = .04, SRMR = .06, accounting for significant portions of the variance in viral load (13%), HRQOL (41%), adherence (7%), and ER visits (9%), as well as the latent variable mental health problems (24%). Only 1 direct link emerged: a positive association between adult abuse and ER visits. Conclusions Findings indicate a significant role of IPV and mental health problems in the health of people living with HIV/AIDS. HIV care providers should assess for IPV history and mental health problems in all patients and refer for evidence-based psychosocial treatments that include a focus on health behaviors.

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“…Individuals exposed to traumatic events are at increased risk for a number of biobehavioral and physical health consequences including disturbed sleep (1, 2), physical health complaints (3), and impaired immune system functioning (4, 5). Independent of trauma, disturbed sleep has been associated with decrements in physical health outcomes (6, 7) and immune system impairments (8, 9, 10).…”

mentioning

confidence: 99%

The Impact of Sleep Complaints on Physical Health and Immune Outcomes in Rescue Workers

Irish

Dougall

Delahanty

et al. 2013

Psychosomatic Medicine

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Objectives The present study examined the extent to which sleep assessed soon after a trauma predicted subsequent physical health and immune functioning in rescue workers. Methods Participants included 159 men and women who performed rescue and clean-up operations at the site of a major airplane crash. One hundred twenty-eight participants were retained for a one-year follow-up. Self-report measures of sleep quality and psychological distress were obtained within 2 months of the crash, and a physical health questionnaire was completed at one-year follow-up. Natural killer (NK) cell number and cytotoxicity were assessed using blood samples collected from a subset of participants (n=51) at the one-year follow-up. Results After adjusting for gender, age, BMI, and initial distress, initial sleep quality complaints were associated with more physical symptoms (β=.32, p<.001), poorer perceived health (β= −.27, p=.009), and increased health care utilization (β=.31, p=.003) at follow-up. In contrast, initial sleep quality was not associated with NK cell number (r=.10, p=.55) or activity (r=.02, p=.90). Change in sleep quality over the year following the crash was not a significant predictor of health or immune outcomes. Conclusions These data suggest that poor sleep quality in the aftermath of trauma signals increased risk for future adverse physical health outcomes, and underscore the importance of addressing sleep complaints soon after trauma to mitigate the negative impact on physical health.

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Psychoneuroimmunology and trauma.

Cited by 17 publications

References 118 publications

Physical Health Problems After Single Trauma Exposure

Physical Health Problems After Single Trauma Exposure

Mental health pathways from interpersonal violence to health-related outcomes in HIV-positive sexual minority men.

The Impact of Sleep Complaints on Physical Health and Immune Outcomes in Rescue Workers

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