“…Our study revealed the patients with BE in Taiwan had poor HRQOL in physical domain but better in environment domain. WHOQOL-BREF is a sensitive tool to evaluate HRQOL for patients with different diseases, such as diabetes mellitus [39], tuberculosis [40], lung cancer [37], inflammatory bowel disease [41], irritable bowel syndrome [42, 43], morbid obesity [30, 35, 44], epilepsy [34], heroin-dependent patients [45] and traumatic limb injury [46]. It is not only useful to compare the difference of HRQOL between cases and controls [34, 35, 38, 42] or subgroups with different severity [35] but also serves as a standard index in validation study for other disease-specific questionnaire [39, 40, 44, 46].…”