Psychological Symptoms in Obesity and Related Factors

Değirmenci, Taner; Kalkan-Oğuzhanoğlu, Nalan; Sözeri-Varma, Gülfizar; Özdel, Osman; Fenkci, Semin

doi:10.5152/npa.2015.6904

Cited by 26 publications

(12 citation statements)

References 53 publications

(49 reference statements)

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“…Obesity, in turn, is an important risk factor for diabetes, a metabolic disease associated to chronic hyperglycemia and an array of other complications (Tebay et al, 2015). A HFD (typically 40–60% of total calorie intake from fat) in humans and animals results in an augmented vulnerability to an array of medical conditions, including many psychiatric disorders where risk positively correlates with BMI (Lopes et al, 2001; Degirmenci et al, 2015). High BMI in human subjects is also linked to reduced blood flow in brain regions important for cognitive function (Willeumier et al, 2011) and reduced brain integrity (Gazdzinski et al, 2008; Stanek et al, 2011).…”

Section: Role Of Nrf2/are Pathway Modulation By Dietary Interventionsmentioning

confidence: 99%

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

2019

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Nuclear factor erythroid 2-related factor 2 (Nrf2) regulates the expression of an array of enzymes with important detoxifying and antioxidant functions. Current findings support the role of high levels of oxidative stress in the pathogenesis of neurological disorders. Given the central role played by Nrf2 in counteracting oxidative damage, a number of studies have targeted the modulation of this transcription factor in order to confer neuroprotection. Nrf2 activity is tightly regulated by oxidative stress and energy-based stimuli. Thus, many dietary interventions based on energy intake regulation, such as dietary energy restriction (DER) or high-fat diet (HFD), modulate Nrf2 with consequences for a variety of cellular processes that affect brain health. DER, by either restricting calorie intake or meal frequency, activates Nrf2 thereby triggering its protective effects, whilst HFD inhibit this pathway, thereby exacerbating oxidative stress. Consequently, DER protocols can be valuable strategies in the management of central nervous system (CNS) disorders. Herein, we review current knowledge of the role of Nrf2 signaling in neurological diseases, namely Alzheimer’s disease, Parkinson’s disease, multiple sclerosis and cerebral ischemia, as well as the potential of energy intake regulation in the management of Nrf2 signaling.

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Section: Role Of Nrf2/are Pathway Modulation By Dietary Interventionsmentioning

confidence: 99%

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

2019

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“…Excessive body weight is also associated with negative psychological consequences that contribute to a deterioration in the quality of life, self-esteem, and eating attitudes. Persons with overweight and obesity are more likely to suffer from symptoms of depression and anxiety [6]. Obesity is often associated with social stigma, so that persons with obesity are not socially accepted because they are regarded as not being motivated and inefficient [7].…”

Section: Introductionmentioning

confidence: 99%

Cognitive consequences of metabolic disorders

Łopuszańska¹,

Cholewa²,

Kozyra³

2020

J Pre Clin Clin Res.

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“…3 With one-third of the world's population being overweight or obese, both developed and developing countries are coping with the challenges posed by this epidemic. 4 Apart from the psychological challenges such as depression, anxiety, eating disorders, and low self-esteem, 5 obesity is also associated with a number of psychiatric disorders. 6 High adiposity also elevates the risk for developing other serious diseases and health conditions such as metabolic syndrome, diabetes, hypertension, dyslipidemia, hyperglycemia, sleep disorders, cardiovascular disease, and osteoarthritis.…”

Section: Introductionmentioning

confidence: 99%

Obesity and cancer: A mechanistic overview of metabolic changes in obesity that impact genetic instability

Kompella

Vásquez

2019

Molecular Carcinogenesis

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Obesity, defined as a state of positive energy balance with a body mass index exceeding 30 kg/m2 in adults and 95th percentile in children, is an increasing global concern. Approximately one‐third of the world's population is overweight or obese, and in the United States alone, obesity affects one in six children. Meta‐analysis studies suggest that obesity increases the likelihood of developing several types of cancer, and with poorer outcomes, especially in children. The contribution of obesity to cancer risk requires a better understanding of the association between obesity‐induced metabolic changes and its impact on genomic instability, which is a major driving force of tumorigenesis. In this review, we discuss how molecular changes during adipose tissue dysregulation can result in oxidative stress and subsequent DNA damage. This represents one of the many critical steps connecting obesity and cancer since oxidative DNA lesions can result in cancer‐associated genetic instability. In addition, the by‐products of the oxidative degradation of lipids (e.g., malondialdehyde, 4‐hydroxynonenal, and acrolein), and gut microbiota‐mediated secondary bile acid metabolites (e.g., deoxycholic acid and lithocholic acid), can function as genotoxic agents and tumor promoters. We also discuss how obesity can impact DNA repair efficiency, potentially contributing to cancer initiation and progression. Finally, we outline obesity‐related epigenetic changes and identify the gaps in knowledge to be addressed for the development of better therapeutic strategies for the prevention and treatment of obesity‐related cancers.

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Psychological Symptoms in Obesity and Related Factors

Cited by 26 publications

References 53 publications

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

Nrf2/ARE Pathway Modulation by Dietary Energy Regulation in Neurological Disorders

Cognitive consequences of metabolic disorders

Obesity and cancer: A mechanistic overview of metabolic changes in obesity that impact genetic instability

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