Psychological Stress on Female Mice Diminishes the Developmental Potential of Oocytes: A Study Using the Predatory Stress Model

Liu, Yuxiang; Cheng, Ya-Nan; Miao, Yun; Wei, De-Li; Zhao, Lihua; Luo, Ming-Jiu; Tan, Jing-He

doi:10.1371/journal.pone.0048083

Cited by 28 publications

(30 citation statements)

References 52 publications

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“…Similar results were obtained in response to dexamethasone in cultured rat preovulatory follicles [116]. Although glucocorticoids seem to impair oocyte development in vitro by increasing apoptosis [117], no alterations in oocyte maturation have been reported in response to high circulating levels of glucocorticoids in vivo [118]. However, the same study highlighted a decreased blastocyst formation, suggesting that glucocorticoids may alter the oocyte potential for fertilization rather than oocyte maturation.…”

Section: Glucocorticoids and Reproductive Functionsupporting

confidence: 72%

Glucocorticoid-Mediated Regulation of Circadian Rhythms: Interface with Energy Homeostasis and Reproduction

Ruginsk¹,

Uchôa²,

Leite³

et al. 2018

Corticosteroids

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All living organisms have evolved by developing concomitant physiological and behavioral adaptations to environment. Through these processes, biological rhythms, such as reproduction, can be synchronized by environmental cues, which include not only the light/dark cycle itself but also the feeding pattern. These adaptations depend on two highly conserved and interrelated systems: an endogenous timing system and the hypothalamic-pituitary-adrenal (HPA) axis. In mammals, the biological circadian rhythms are controlled by a "master oscillator," the suprachiasmatic nucleus of the hypothalamus (SCN). Through neural signals to paraventricular nucleus of hypothalamus (PVN), the SCN also modulates the activation of the HPA axis, ultimately resulting in the circadian rhythm of glucocorticoid secretion by the adrenal cortex. Glucocorticoids, in turn, are well known for their important role in the regulation of energy homeostasis. Accordingly, obese animals exhibit increased glucocorticoid levels and are more susceptible to glucocorticoid-induced anabolic effects. In parallel, glucocorticoids modulate reproductive function and fertility: at physiological levels, glucocorticoids control the timing of puberty onset and gonadal steroidogenesis, as well modulate the immune system, which determines conception and pregnancy progression. However, stress-induced glucocorticoid secretion may exert a dual effect on reproductive function.

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Section: Glucocorticoids and Reproductive Functionsupporting

confidence: 72%

Glucocorticoid-Mediated Regulation of Circadian Rhythms: Interface with Energy Homeostasis and Reproduction

Ruginsk¹,

Uchôa²,

Leite³

et al. 2018

Corticosteroids

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“…showed early life stress was associated with disconfiguration of oocyte chromatin, which reduced the developmental competence . To investigate the psychological stress on the development of mouse oocytes, Liu et al ., put a cat next to a mouse cage as a hunter model and found that psychological stress can reduce the developmental competence of the oocytes and result in the decrease of the rate of blastocyte formation. Bhat et al ., also examined the effect of maternal separation stress on atresia in ovarian follicles and showed that stress causes apoptosis in granulosa cells of follicles .…”

Section: Discussionmentioning

confidence: 99%

Implications from early life stress on the development of mouse ovarian follicles: Focus on oxidative stress

Ghatebi

Zavareh

Lashkarbolouki

et al. 2019

J of Obstet and Gynaecol

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Aim: The early life stress has significant long-term effects on the development of the offspring. This study was undertaken to verify if maternal separation as a stressor agent affects the oxidative status and developmental competence of mouse pre-antral follicles (PF) during in vitro culture period. Methods: Female litters of National Medical Research Institute mice were divided into two groups: maternally separated group (MS), separated from the mothers for 6 h per day from postnatal days 2-16; and the rest considered as the control group, which left undisturbed over the 14 days. The litters were sacrificed and the ovarian tissue was harvested to isolate the PF. The PF were in vitro cultured up to 12th day when ovulation was induced. The developmental parameters and oxidative status (i.e., total antioxidant capacity and Malondialdehyde levels, as well as the activities of superoxide dismutase, glutathione peroxidase and catalase) were assessed. Results: The rates of survival, antrum formation, ovulation and oocyte maturation of PF derived from the MS group were significantly lower compared with those of the control group. Furthermore, the Malondialdehyde level of the MS group was significantly higher than that of the control group. By contrast, the total antioxidant capacity level was lower in the MS group with respect to the control group. Also, the activity of superoxide dismutase, glutathione peroxidase and catalase of PF, derived from the MS group, was significantly lower compared with those of the control group. Conclusion: Early life stress damages the developmental competence of mouse PF through induction of oxidative stress.The developmental competence of PF was assessed by measuring the follicle diameter on the 2nd and 4th day of the cultivation period, antrum formation, 1507

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“…An increase in plasma cortisol levels along witb increasing corticosteroid-binding globulin (CBG) levels stimulate maternal metabolism and tbe mobilization of maternal resources to sustain embryo requirements (Nolten & Rueckert, 1981;Laudat et al, 1987). However, tbe elevation of plasma glucocorticoid levels is considered a double-edged process because wben abundantly released under stressful conditions tbese bormones can perturb reproduction (Breuner et al, 2008;Liu et al, 2012). Indeed, abundant release of glucocorticoids caused by a stimulation of tbe bypotbalamic-pituitary adrenal axis (HPA) can perturb tbe bypotbalamic-pituitary gonadic axis; for instance via tbe inbibition of tbe secretion of luteinizing bormone, and consequently can negatively impact tbe ovarian secretion of essential sex steroid bormones (Cbatterton, 1990;Magiakou et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

Effect of a brief stress on progesterone plasma levels in pregnant and non-pregnant guinea pigs

Michel

Bonnet

2014

Animal Biol

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International audienceSteroid hormones are essential for vertebrate reproduction. They are involved in the regulation of major female reproductive events like ovulation, embryo implantation, or gestation. For instance, progesterone promotes foeto-maternal exchanges whereas glucocorticoids stimulate the mobilization of the required energy resources. However, glucocorticoids are key effectors of the stress response; chronic elevations of these hormones can exert negative effects on reproduction. Yet, little is known about the effects of a brief exposure to a stressor on the respective plasma concentrations of sex steroids and glucocorticoids, notably during pregnancy. We examined the impact of a brief stress (handling + 1.5 hours in a bag) on progesterone and cortisol plasma concentrations in pregnant and non-pregnant female guinea pigs. Analyses revealed that: 1) pregnant females exhibited higher baseline progesterone and cortisol concentrations compared to non-pregnant females, as expected; 2) cortisol concentrations increased rapidly following manipulation, revealing a typical hormonal stress response; and, 3) progesterone concentrations decreased on average by 50.9% following the brief stress period, both in pregnant and non-pregnant individuals. These experimental results show for the first time a drastic and rapid impact on progesterone concentration caused by a brief stress

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Psychological Stress on Female Mice Diminishes the Developmental Potential of Oocytes: A Study Using the Predatory Stress Model

Cited by 28 publications

References 52 publications

Glucocorticoid-Mediated Regulation of Circadian Rhythms: Interface with Energy Homeostasis and Reproduction

Glucocorticoid-Mediated Regulation of Circadian Rhythms: Interface with Energy Homeostasis and Reproduction

Implications from early life stress on the development of mouse ovarian follicles: Focus on oxidative stress

Effect of a brief stress on progesterone plasma levels in pregnant and non-pregnant guinea pigs

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