Psychological Stress May Induce Diabetes-Related Autoimmunity in Infancy

Sepa, Anneli; Wahlberg, Jeanette; Vaarala, Outi; Frodi, Ann; Ludvigsson, Johnny

doi:10.2337/diacare.28.2.290

Cited by 86 publications

(90 citation statements)

References 27 publications

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“…Earlier exposure has been investigated, but with inconsistent results [7,8,10,12,16]. In ABIS, experience of SLEs early in a child's life has previously been associated with the development of diabetes-related autoantibodies [38,39], but not with manifest diabetes [18]. Our current results suggest that experience of an SLE at any time in childhood may contribute to manifest diabetes and strengthen the hypothesis that psychological stress can influence the immunological process.…”

Section: Strengths and Limitations Of The Studysupporting

confidence: 74%

“…Previously in ABIS, parenting stress occurring when children were 1 year of age was associated with the presence of diabetes-related autoantibodies [39], but not with a diagnosis of type 1 diabetes [18]. The current study that examined parenting stress until children were age 8 years did not find any association with manifest diabetes.…”

Section: Strengths and Limitations Of The Studymentioning

confidence: 59%

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Experience of a serious life event increases the risk for childhood type 1 diabetes: the ABIS population-based prospective cohort study

et al. 2015

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Aims/hypothesis The aim of this study was to prospectively investigate whether psychological stress during childhood may be a risk factor for manifest type 1 diabetes. Methods The All Babies In Southeast Sweden (ABIS) study invited all families with babies born between 1 October 1997 and 30 September 1999 in southeast Sweden to participate. Our study subsample includes 10,495 participants in at least one of the data collections at 2-3, 5-6, 8 and 10-13 years of age not yet diagnosed with type 1 diabetes at inclusion; 58 children were subsequently diagnosed. Age at diagnosis was obtained from the national register SweDiabKids in 2012. Family psychological stress was measured via questionnaires given to the parents assessing serious life events, parenting stress, parental worries and the parent's social support. Results Childhood experience of a serious life event was associated with a higher risk of future diagnosis of type 1 diabetes (HR 3.0 [95% CI 1.6, 5.6], p=0.001) after adjusting for heredity of type 1 diabetes and age at entry into the study. The result was still valid when controlling for heredity of type 2 diabetes, size for gestational age, the parents' education level and whether the mother worked at least 50% of full time before the child's birth (HR 2.8 [95% CI 1.5, 5.4], p = 0.002), and also when childhood BMI was added to the model (HR 5.0 [95% CI 2.3, 10.7], p<0.001). Conclusions/interpretation This first prospective study concluded that experience of a serious life event in childhood may be a risk factor for manifest type 1 diabetes.

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Section: Strengths and Limitations Of The Studysupporting

confidence: 74%

Section: Strengths and Limitations Of The Studymentioning

confidence: 59%

Experience of a serious life event increases the risk for childhood type 1 diabetes: the ABIS population-based prospective cohort study

et al. 2015

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“…However, a recent metaanalysis of nine prospective studies reported that depressed adults have a 37% increased risk of developing type 2 diabetes [45]. Negative life events during the first 2 years of life, such as divorce, high parenting stress and foreign origin of the mother predicted an increased risk of diabetesrelated autoimmunity, which critically contributes to the development of type 1 diabetes [46,47]. In addition, inflammatory cytokines such as IL-6 are known to increase in response to acute psychosocial stress [48], and these inflammatory markers have also been prospectively associated with an increased risk of diabetes among a large cohort of postmenopausal women [49].…”

Section: Discussionmentioning

confidence: 99%

An association of adverse psychosocial factors with diabetes mellitus: a meta-analytic review of longitudinal cohort studies

Chida

Hamer

2008

Diabetologia

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Aims/hypothesis There has been substantial interest in the association between psychosocial stress and risk of diabetes mellitus, but no data on the systematic quantification of the causal relationship have been published. This analysis aims to evaluate the association between adverse psychosocial factors and diabetes mellitus. Methods We performed a search of Medline, PsycINFO, Web of Science and PubMed up to July 2008. The studies included were prospective cohort studies investigating the association between adverse psychosocial factors and risk of diabetes mellitus. Results There were 22 relationships between psychosocial factors and disease-related factors (in 14 papers), of which 16 evaluated the associations of adverse psychosocial factors with diabetes control in diabetic populations and six evaluated the associations of adverse psychosocial factors with the incidence of diabetes in populations without any diagnosed diabetes. The overall meta-analysis demonstrated that adverse psychosocial factors were significantly associated with poor diabetes control (combined correlation coefficient, r=0.096, p=0.006), whereas adverse psychosocial factors were not associated with incident diabetes mellitus. More notably, sensitivity analyses showed that low social support was more robustly associated with poor diabetes control than stressful events per se or stress-prone personality or coping style, and that adverse psychosocial factors were associated with poor control of type 1 and type 2 diabetes. Conclusions/interpretation The current review revealed a detrimental association of psychosocial factors with the prognosis of both type 1 and type 2 diabetes. However, any aetiological effect of adverse psychosocial factors remains elusive as a result of the small number of individuals enrolled in the cohorts studied.

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“…There is already some evidence that rapid growth and obesity in early childhood increases the risk of Type 1 diabetes [19]. Further, psychological stress in families has been found to be associated with diabetes-associated autoantibodies in 1-year-old children [20]. Recent studies [21][22][23][24] have shown that environmental factors have a stronger effect on genetically non-susceptible individuals than those genetically susceptible to getting Type 1 diabetes.…”

Section: Discussionmentioning

confidence: 99%

Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999

2006

Diabetic Medicine

947

309

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Aims To examine incidence and trends of Type 1 diabetes worldwide for the period 1990-1999.Methods The incidence of Type 1 diabetes (per 100 000/year) was analysed in children aged ≤ 14 years from 114 populations in 112 centres in 57 countries. Trends in the incidence of Type 1 diabetes were analysed by fitting Poisson regression models to the dataset.Results A total of 43 013 cases were diagnosed in the study populations of 84 million children. The age-adjusted incidence of Type 1 diabetes among 112 centres (114 populations) varied from 0.1 per 100 000/year in China and Venezuela to 40.9 per 100 000/year in Finland. The average annual increase in incidence calculated from 103 centres was 2.8% (95% CI 2.4 -3.2%). During the years 1990-1994, this increase was 2.4% (95% CI 1.3-3.4%) and during the second study period of 1995-1999 it was slightly higher at 3.4% (95% CI 2.7-4.3%). The trends estimated for continents showed statistically significant increases all over the world (4.0% in Asia, 3.2% in Europe and 5.3% in North America), except in Central America and the West Indies where the trend was a decrease of 3.6%. Only among the European populations did the trend in incidence diminish with age. ConclusionsThe rising incidence of Type 1 diabetes globally suggests the need for continuous monitoring of incidence by using standardized methods in order to plan or assess prevention strategies. Diabet. Med. 23, 857-866 (2006) Keywords epidemiology, geographical distribution, incidence, trend, Type 1 diabetes In this study we investigated the age-and sex-specific incidence of Type 1 diabetes and trends in incidence between 1990 and 1999 worldwide.

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Psychological Stress May Induce Diabetes-Related Autoimmunity in Infancy

Cited by 86 publications

References 27 publications

Experience of a serious life event increases the risk for childhood type 1 diabetes: the ABIS population-based prospective cohort study

Experience of a serious life event increases the risk for childhood type 1 diabetes: the ABIS population-based prospective cohort study

An association of adverse psychosocial factors with diabetes mellitus: a meta-analytic review of longitudinal cohort studies

Incidence and trends of childhood Type 1 diabetes worldwide 1990–1999

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