Psychological Stress: A Predisposing and Exacerbating Factor in Periodontitis

Spector, Anna; Postolache, Teodor T.; Akram, Faisal; Scott, Alison; Wadhawan, Abhishek; Reynolds, Mark A.

doi:10.1007/s40496-020-00282-2

Cited by 28 publications

(24 citation statements)

References 90 publications

(107 reference statements)

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“…Emerging evidence suggests that chronic stress and related diseases, such as depression and anxiety, may be significant factors contributing to the development of oral dysbiosis, progression of periodontal/ peri-implant disease, and inconsistent wound healing following periodontal therapy. 125,[224][225][226] Moreover, the stress hormone, cortisol, has been shown to directly induce shifts in the composition of the oral microbial community and in its gene expression profiles in vitro, which reproduces results found for the gene expression profiles of the oral microbial community in periodontal disease and during its progression. 94…”

Section: Oral Microbiome In Systemic Diseasesupporting

confidence: 76%

The oral microbiome: Role of key organisms and complex networks in oral health and disease

Sedghi

DiMassa

Harrington

et al. 2021

Periodontology 2000

297

165

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The field of human microbiome research has undergone a revolution in its approach toward understanding how microorganisms influence the physiology of their host. 1 Development of culture-independent methods has resulted in increased detection and classification of microbial species within microbial communities. 2 technologies, biomarker sequencing, and shotgun metagenomics have become standard tools used to determine the composition and genetic makeup of the human microbiome. 3 Other "-omics" technologies, such as proteomics and metabolomics, support mechanistic hypotheses involved in causal microbial pathways that are related to states of health and disease. 4,5 Since Antonie van Leeuwenhoek first discovered the existence of microbes in the 1700s while analyzing dental plaque under a microscope, the composition of oral microbial communities has been extensively studied. 6 Over 250 species from the oral cavity have been isolated in culture and characterized, including several key pathogens, such as Streptococcus mutans, Porphyromonas gingivalis, Tannerella forsythia, and Aggregatibacter actinomycetemcomitans, involved in the etiology of dental caries and periodontal disease. [7][8][9] An integrated approach toward understanding states of oral disease from the polymicrobial perspective has emerged over time, attributing disease pathology not only to key pathogens but rather to networks of co-occurring microbes, the collective activities of which contribute to pathogenesis. [9][10][11][12] As such, the importance of understanding the divergences, between oral health and disease, in the microbes comprising the system as well as their relative abundance and functional activity, in addition to genetic factors and ecological pressures that drive such changes, is a primary focus of research within the field of oral health research. 9,[13][14][15][16][17] In recent decades, genetic approaches have shed light on the functional capacity of members of oral microbiomes, the mechanistic underpinnings of caries and periodontal disease pathogenesis, and the complex dynamics and fitness factors of key organisms in oral microbiomes. 3,18 The oral microbial ecosystem is constantly exposed to exogenous foreign substances. 17 Such circumstances are defining factors for founding microbes and their ability to persist in this environment, and make for distinct relationships between microbe and host that rely on selective pressures. Pioneer microbial colonizers of the oral cavity, such as Streptococcus mitis, Streptococcus sanguinis, Streptococcus gordonii, and Streptococcus salivarius, display core characteristics that make them well suited to this specific niche as they are able to bind selectively to tongue and cheek cells before the teeth emerge and can outcompete other microbial species. 17,19 Emerging teeth acquire a protective glycoprotein coat, which sets in motion successional microbial colonization, resulting in the development of complex polymicrobial biofilm communities, namely dental plaque. 20 These complex dental plaque m...

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Section: Oral Microbiome In Systemic Diseasesupporting

confidence: 76%

The oral microbiome: Role of key organisms and complex networks in oral health and disease

Sedghi

DiMassa

Harrington

et al. 2021

Periodontology 2000

297

165

View full text Add to dashboard Cite

show abstract

“…Several recent systematic reviews of the current literature have pointed to an increasing platform linking chronic psychosocial stress/disorders with diseases of the periodontium/periosteum [1][2][3] attributable to dynamics in the immune system, oral microbiome shifts/biofilm formation, enzymatic-mediated protein/collagen turnover ratios, and local/systemic disease progression. 4 Towards this end, there are three possible interactions between the periodontium/periosteum and stress: stress → periodontium/periosteum, periodontium/periosteum ← stress, and stress ↔ periodontium/periosteum. 5 These three interactions will be explored throughout this paper to assess the psychobiologic links between chronic stress-related diseases and periodontal/peri-implant diseases.…”

Section: Introductionmentioning

confidence: 99%

The psychobiological links between chronic stress‐related diseases, periodontal/peri‐implant diseases, and wound healing

Decker

Kapila

Wang

2021

Periodontology 2000

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“…They suggest that a complex biological indicator to be established in a series of studies will allow treatment tailored to risk level, which may be beneficial for future personalized periodontics. In addition, Spector et al showed that stress affects periodontal disease by enhancing bacteriological factors through impaired antimicrobial defense, more pathogenic gene expression, and shifts in the oral microbiome profile with taxa composition [ 152 ].…”

Section: Next-generation Procedures In Periodontal Diseasementioning

confidence: 99%

Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

Kikuchi

Hayashi

Mitani

2022

JPM

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Periodontal disease, a major cause of tooth loss, is an infectious disease caused by bacteria with the additional aspect of being a noncommunicable disease closely related to lifestyle. Tissue destruction based on chronic inflammation is influenced by host and environmental factors. The treatment of periodontal disease varies according to the condition of each individual patient. Although guidelines provide standardized treatment, optimization is difficult because of the wide range of treatment options and variations in the ideas and skills of the treating practitioner. The new medical concepts of “precision medicine” and “personalized medicine” can provide more predictive treatment than conventional methods by stratifying patients in detail and prescribing treatment methods accordingly. This requires a new diagnostic system that integrates information on individual patient backgrounds (biomarkers, genetics, environment, and lifestyle) with conventional medical examination information. Currently, various biomarkers and other new examination indices are being investigated, and studies on periodontal disease-related genes and the complexity of oral bacteria are underway. This review discusses the possibilities and future challenges of precision periodontics and describes the new generation of laboratory methods and advanced periodontal disease treatment approaches as the basis for this new field.

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Psychological Stress: A Predisposing and Exacerbating Factor in Periodontitis

Cited by 28 publications

References 90 publications

The oral microbiome: Role of key organisms and complex networks in oral health and disease

The oral microbiome: Role of key organisms and complex networks in oral health and disease

The psychobiological links between chronic stress‐related diseases, periodontal/peri‐implant diseases, and wound healing

Next-Generation Examination, Diagnosis, and Personalized Medicine in Periodontal Disease

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