The present study investigated 261 Mexican‐American college students' performance on the Psychological Screening Inventory (PSI), a brief personality instrument designed to detect persons who might benefit from more extensive evaluations in mental health settings. In addition to providing PSI results against which other Hispanic‐American populations can be compared, this study examined the relationship between the acculturation level of the subjects and their PSI performance. Only one of the five PSI subscales (Alienation) correlated significantly with acculturation, which suggests that increases in acculturation are associated with fewer feelings of alienation.