Psychological repercussions related to brachytherapy treatment in women with gynecological cancer: analysis of production from 1987 to 2007

Barros, Gisele Curi de; Labate, Renata Curi

doi:10.1590/s0104-11692008000600018

Cited by 8 publications

(6 citation statements)

References 5 publications

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“…Radiation treatment causes stomatitis, mucositis, esophagitis, gastroenteritis, loss of taste, nausea, vomiting, diarrhea, constipation, bleeding, and proctitis, which lead to difficulties eating and in digestion [18,19]. Malnutrition caused by radiation weakens immunity, which, in turn, increases the rate of infection, reduces the reaction to treatment, weakens the whole body, reduces quality of life, and ultimately leads to death [20,21]. …”

Section: Introductionmentioning

confidence: 99%

Effect of quercetin on impaired immune function in mice exposed to irradiation

2012

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Radiation used in cancer treatment may cause side effects such as inflammation. Quercetin is a polyphenol that reduces inflammation. This study evaluated the recovery efficacy of quercetin on impaired immune function in irradiation-induced inflammatory mice. Quercetin administered at two concentrations of 10 and 40 mg/kg body weight was initiated 2 weeks before irradiation and was continued 30 days after irradiation. The animals exposed/not exposed to radiation were sacrificed on radiation days 10 and 30. Splenocyte proliferation, which was diminished after irradiation, was enhanced significantly by quercetin supplementation after 30 days of irradiation. Cytokine secretion increased in the radiation group compared to that in the non-radiation control group. After 30 days of radiation, interleukin (IL)-1β and IL-6 secretion decreased significantly in the radiation-quercetin groups. When quercetin was administered for 44 days, it showed a possible protective effect against irradiation-induced inflammation in mice. Quercetin could be beneficial in the recovery of irradiation-induced increases in cytokine secretion.

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Section: Introductionmentioning

confidence: 99%

Effect of quercetin on impaired immune function in mice exposed to irradiation

2012

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“…Additionally, radiation damages the vaginal mucosa and epithelium. Moreover, there are other side effects of radiotherapy such as nausea, vomiting, diarrhoea, constipation, mucositis, weight changes and hormonal changes [23].…”

Section: Discussionmentioning

confidence: 99%

PrediQt-Cx: Post Treatment Health Related Quality of Life Prediction Model for Cervical Cancer Patients

et al. 2014

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BackgroundCervical cancer is the third largest cause of cancer mortality in India. The objectives of the study were to compare the pre and the post treatment quality of life in cervical cancer patients and to develop a prediction model to provide an insight into the possibilities in the treatment modules.Methodology/Principal FindingsA total of 198 patients were assessed with two structured questionnaires of Health Related Quality of Life (The European Organisation for Research and Treatment of Cancer, EORTC QLQ C-30 and CX-24). The baseline observations were recorded when the patients first reported (T1) and second evaluation was done at 6 months post treatment (T2). The mean age of detection was 50.9 years with the literacy level being non-educated or less than high school. Majority of them were married/cohabiting 179 (90.4%). On histopathological examination (HPE) squamous cell carcinoma was found to be the most common cell type carcinoma 147 (74.2%) followed by Adenocarcinoma 31 (15.7%). Radical hysterectomy was the most common treatment modality 76 (38.4%), followed by Wertheims Hysterectomy 46 (23.2%) and Radiochemotherapy 59 (29.8%). The mean score of global health of cervical cancer patients post treatment was 77.90, which was significantly higher than the pre - treatment score (54.32). Mean “symptoms score” post treatment was 21.69 with an aggravation of 7.32 compared to pre treatment scores. Patients experienced substantial decrease in sexual activity post treatment.Conclusions/SignificanceThe prediction model(PrediQt-Cx), based on Support Vector Machine(SVM) for predicting post treatment HRQoL in cervical cancer patients was developed and internally cross validated. After external validation PrediQt-Cx can be easily employed to support decision making by clinicians and patients from north India region, through openly made available for access at http://prediqt.org.

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“…Five studies were randomised controlled studies (RCTs), 16,17,18,19,20 two case control studies, 21,22 nine cohort studies, 11,12,23,24,25,26,27,28,29 five qualitative studies 30,31,32,33,34 and 1 systematic literature review. 35…”

Section: Resultsmentioning

confidence: 99%

“…Critical appraisal with appropriate CASP tools led to exclusion of three studies due poor methodology or not enough information. 22,29,35 See Table 3 for summary of the critical appraisal. The three studies excluded at this stage had a large majority (>75%) of negative answers or "can't tell" when the CASP tools were applied.…”

Section: Critical Appraisalmentioning

confidence: 99%

The experiences of women receiving brachytherapy for cervical cancer: A systematic literature review

Humphrey¹,

Bennett

Cramp

2018

Radiography

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Objectives: To determine women's experiences of brachytherapy for cervical cancer. Key findings: Nineteen studies were included for data extraction/synthesis. Twelve studies focussed on psychological issues, seven on pharmacological aspects of women's experiences. Themes of anxiety, distress, pain, informational needs and non-pharmacological interventions were found. Nine out of ten psychological studies described brachytherapy as a distressing experience causing anxiety and distress for most women. Non-pharmacological interventions were found to be effective and inexpensive adjuncts. Peri and post-operative pharmacological management was variable, but duration of procedure was an important factor. Conclusion: Brachytherapy for gynaecological cancer causes varying levels of pain, anxiety and distress. To improve women's experiences there needs to be better pain management, patient information and the development of non-pharmacological interventions. Future recommendations are to develop clinical support guidelines, audit the quality of services and develop effective interventions to improve women's experiences of brachytherapy for locally advanced cervical cancer.

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Psychological repercussions related to brachytherapy treatment in women with gynecological cancer: analysis of production from 1987 to 2007

Cited by 8 publications

References 5 publications

Effect of quercetin on impaired immune function in mice exposed to irradiation

Effect of quercetin on impaired immune function in mice exposed to irradiation

PrediQt-Cx: Post Treatment Health Related Quality of Life Prediction Model for Cervical Cancer Patients

The experiences of women receiving brachytherapy for cervical cancer: A systematic literature review

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