Since its inception in the 1980s, through further developments during the 1990s, and continuing today, the paradigm of allostatic load (AL) has becomed an important paradigm for predicting senescence and mortality. AL is a cumulative measure of the effects of multiple stressors and the process of responding to stressors on the soma. AL measurements of individuals is being tested on various samples and species and being reported across a variety of medical and social science journals. From the ISI Web of Science, all articles published between January 2000 and June 2005 with AL in any default category were obtained and transferred to Endnote. These articles, categorized as theory/review or data-driven, human or animal, and variability in risk factors used to estimate AL, are reviewed here. Only two of 90 reports were published in anthropological journals, likely, at least partly, because research on AL has focused more on western, industrialized populations where data are more easily obtained. From 2000From -2005 of 42 data-driven reports focused on elderly humans. Studies of animal models also are common (0 in 2000, but 4 in 2004 covering 21 species). During the last year, multiple additional potential physiological variables have been tested as measures of AL (10 to 20 in any one article). In the past half decade, AL also has been introduced to a wide range of disciplines, including psychology, anthropology, gerontology, veterinary medicine, and medical specialties, as a viable research theme. AL appears to provide a useful method for determining cumulative somatic stress such as that seen with senescence and frailty at older ages. J Physiol Anthropol 25(1): [133][134][135][136][137][138][139][140][141][142][143][144][145] 2006 http:// www.jstage.jst.go.jp/browse/jpa2 [DOI: 10.2114/jpa2.25.133] Keywords: allostatic load, stress, senescence, aging
IntroductionBiological anthropology, with its Boazian origins in documenting developmental plasticity in United States immigrants, has long been interested in environmental effects on human biology. Moving beyond a focus on short term responses to stress (e.g., Cannon, 1929 ) and a Livingstonian model of genetic adaptation (Williams, 2003), biological anthropology has rediscovered its roots and begun to examine the cumulative effect of stress on humans (Bogin, 1999). Several authors (e.g., Goodman and Leatherman, 1998;Thomas, 1998) have concluded that human variation cataloged during studies of adaptability were in reality examples of prolonged nutritional and disease stress on populations resulting from global capitalism. The concept of allostatic load (AL) was developed to measure the effects of long-term exposure to stress on humans. AL potentially offers a comprehensive measure of long term stress, however it was developed during studies of relatively affluent, highfunctioning elderly Western cohorts. Physiological anthropology, focusing on variation between and within populations, is particularly suited to refining the concept of AL and testing its ...