Psychological and Social Implications of Aging Skin: Normal Aging and the Effects of Cutaneous Disease

Farage, Miranda A.; Miller, Kenneth W.; Berardesca, Enzo; Maibach, Howard I.

doi:10.1007/978-3-642-27814-3_89-2

Cited by 6 publications

(4 citation statements)

References 74 publications

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“…Poor skin quality can result from a myriad of factors and may negatively impact a person's emotional health, quality of life, self-perception, and interactions with others. 45 – 47 Importantly, self-perception is affected by interactions with, and judgements by, others. Multiple studies have shown that skin, as a person's primary interface with their surroundings, 26 influences others' judgments of one's health, personality traits, youthfulness, and emotional and psychological well-being.…”

Section: Importance Of Skin Qualitymentioning

confidence: 99%

Defining Skin Quality: Clinical Relevance, Terminology, and Assessment

et al. 2021

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Section: Importance Of Skin Qualitymentioning

confidence: 99%

Defining Skin Quality: Clinical Relevance, Terminology, and Assessment

et al. 2021

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“…Aged skin thus plays an important role in our mental health. Skin that does not feel good or look good can be burdensome emotionally and can cause emotional distress like anxiety, depression, and social withdrawal, making it important for aging people to prevent skin wrinkles [16,39]. While it is necessary to design anti-wrinkle agents that successfully target the skin aging mechanism (see more in Figure 2), it is also of utmost importance to address the need for enhancing the administration of anti-wrinkle therapies.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Hollow Microneedles for Treating Skin Wrinkles Using Different Anti-Wrinkle Agents: A Possible Futuristic Approach

Islam¹,

Poly²,

Tisha³

et al. 2023

Cosmetics

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Skin wrinkles are an inevitable phenomenon that is brought about by aging due to the degradation of scleroprotein fibers and significant collagen reduction, which is the fundamental basis of anti-wrinkle technology in use today. Conventional treatments such as lasering and Botulinum toxin have some drawbacks including allergic skin reactions, cumbersome treatment procedures, and inefficient penetration of the anti-wrinkle products into the skin due to the high resistance of stratum corneum. Bearing this in mind, the cosmetic industry has exploited the patient-compliant technology of microneedles (MNs) to treat skin wrinkles, developing several products based on solid and dissolvable MNs incorporated with antiwrinkle formulations. However, drug administration via these MNs is limited by the high molecular weight of the drugs. Hollow MNs (HMNs) can deliver a wider array of active agents, but that is a relatively unexplored area in the context of antiwrinkle technology. To address this gap, we discuss the possibility of bioinspired 3D printed HMNs in treating skin wrinkles in this paper. We compare the previous and current anti-wrinkling treatment options, as well as the techniques and challenges involved with its manufacture and commercialization.

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“…Skin aging is one of the factors strongly affecting self-esteem. It can often become a severe problem due to high societal pressure [12][13][14][15][16]. Decreased self-esteem and even potential depressive states, in many cases, lead to severe issues with overall health.…”

Section: Introductionmentioning

confidence: 99%

Cell Level- Modeling of Aging and Rejuvenation

Koptyug,

Sukhovei,

Kostolomova

et al. 2023

OBM Geriatr

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Understanding processes related to human aging and rejuvenation relies on experimental data and advanced models operating at different levels. There are several existing conceptual and specific modeling approaches. However, one of the existing tasks is compiling generic models linking properties at cell and cell-element levels to properties at systemic levels - tissue, organ, and whole body. One of the critical issues in the relevant models is the enormity of interacting components at the cell and sub-cell levels needed to represent the properties of high-level systems properly. This paper describes a promising approach to modeling and simulation at the cell population level for studying aging and rejuvenation. It also presents initial conclusions formulated based on the results of modeling and experiments coupled to it. The model is based on the concepts of the proliferation niche and homeostatic cell number stabilization in the cell population through the associated action of proliferation and apoptosis. Importantly, we address the issue of defining “aging” and “rejuvenation” for cell populations containing large numbers of cells of different ages. It is possible to demonstrate that homeostatic regulation can be performed by maintaining the concentration of a single regulatory substance. Predictions and simulations of the proposed model are compared to data from existing publications and experiments specifically conducted to validate the model. Currently, none of the available data contradicts the modeling results at the proposed level of detail. However, an inadequate number of elements and the employed statistical approach further limit progress in such modeling. Expanding the proposed method to include a realistic number of features representing human tissues, organs, and body and to allow for proper modeling of aging and rejuvenation processes requires more advanced modeling techniques.

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Psychological and Social Implications of Aging Skin: Normal Aging and the Effects of Cutaneous Disease

Cited by 6 publications

References 74 publications

Defining Skin Quality: Clinical Relevance, Terminology, and Assessment

Defining Skin Quality: Clinical Relevance, Terminology, and Assessment

3D Printed Hollow Microneedles for Treating Skin Wrinkles Using Different Anti-Wrinkle Agents: A Possible Futuristic Approach

Cell Level- Modeling of Aging and Rejuvenation

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