3D Printed Hollow Microneedles for Treating Skin Wrinkles Using Different Anti-Wrinkle Agents: A Possible Futuristic Approach

Abstract

Skin wrinkles are an inevitable phenomenon that is brought about by aging due to the degradation of scleroprotein fibers and significant collagen reduction, which is the fundamental basis of anti-wrinkle technology in use today. Conventional treatments such as lasering and Botulinum toxin have some drawbacks including allergic skin reactions, cumbersome treatment procedures, and inefficient penetration of the anti-wrinkle products into the skin due to the high resistance of stratum corneum. Bearing this in mind, the cosmetic industry has exploited the patient-compliant technology of microneedles (MNs) to treat skin wrinkles, developing several products based on solid and dissolvable MNs incorporated with antiwrinkle formulations. However, drug administration via these MNs is limited by the high molecular weight of the drugs. Hollow MNs (HMNs) can deliver a wider array of active agents, but that is a relatively unexplored area in the context of antiwrinkle technology. To address this gap, we discuss the possibility of bioinspired 3D printed HMNs in treating skin wrinkles in this paper. We compare the previous and current anti-wrinkling treatment options, as well as the techniques and challenges involved with its manufacture and commercialization.

Hyaluronic Acid as a Mechanism to Mitigate the Effects of Face Lower Third Aging in Dentistry: A Review

“…The research studies by Kapoor et al [58], Rauso et al [59], Hernandez et al [60], and Islam et al [61] also address different aspects of skin aging and the aesthetic approaches used for facial rejuvenation, adding evidence that HA and botulinum toxin are safe and effective options in dentistry for facial rejuvenation, thus supporting the abovementioned findings. These fillers can fill wrinkles, increase skin hydration, improve elasticity, and provide a more youthful and balanced appearance.…”

Liquid for Fused Deposition Modeling Technique (L-FDM)—A Revolution in Application Chemicals to 3D Printing Technology: Color and Elements

“…Specifically, this technique can help in printing skin delivery platforms such as patches and microneedles [29]. Printed cosmetic microneedles can be a delivery system for both hydrophilic and lipophilic active ingredients that will be introduced into the material during the L-FDM process [30]. According to scientific research, the use of 3D printing allows for the customization of dressings to fit the specific needs of each patient.…”

Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold

“…Microneedles have attracted substantial interest across diverse domains, including cosmetics [2,3], drug delivery systems (DDS) [4,5], and biological sensing for disease diagnosis [6,7]. For example, the cosmetics industry is leveraging microneedle technology to treat skin wrinkles and is developing several solid and dissolvable microneedle-based products incorporating anti-wrinkle formulations [8,9]. In the pharmaceutical industry, the development of dissolvable microneedle patches for insulin [10,11] and vaccines [12] is expected.…”