2008
DOI: 10.1590/s1516-44462008000100012
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Psychobiology of childhood maltreatment: effects of allostatic load?

Abstract: 4; mediana: 5,88

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Cited by 90 publications
(75 citation statements)
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References 86 publications
(105 reference statements)
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“…14,24 It is thought that early-life stress can have detrimental neurobiological effects, including disturbances in processes such as synaptic production and elimination (pruning) 25 and hypothalamus-pituitary-adrenal (HPA) axis regulation. [26][27][28] It has also been suggested that early-life stress can cause inappropriate stimulation of neurotransmitters, neuroendocrine hormones and neurotrophins essential for normal brain development 29 and that it may lead to vulnerability for the development of MDD. 30 Since the hippocampus plays an essential role in emotion processing, behaviour and memory, 31 the ACC in emotion and cognitive function, 32 and the prefrontal cortex (frontopolar regions) in executive functions like decision-making, 33 structural changes to these regions can disrupt these functions and thus the psychological state of a person; therefore, it is implicit to study them in the context of MDD and childhood maltreatment.…”
Section: Introductionmentioning
confidence: 99%
“…14,24 It is thought that early-life stress can have detrimental neurobiological effects, including disturbances in processes such as synaptic production and elimination (pruning) 25 and hypothalamus-pituitary-adrenal (HPA) axis regulation. [26][27][28] It has also been suggested that early-life stress can cause inappropriate stimulation of neurotransmitters, neuroendocrine hormones and neurotrophins essential for normal brain development 29 and that it may lead to vulnerability for the development of MDD. 30 Since the hippocampus plays an essential role in emotion processing, behaviour and memory, 31 the ACC in emotion and cognitive function, 32 and the prefrontal cortex (frontopolar regions) in executive functions like decision-making, 33 structural changes to these regions can disrupt these functions and thus the psychological state of a person; therefore, it is implicit to study them in the context of MDD and childhood maltreatment.…”
Section: Introductionmentioning
confidence: 99%
“…From a neurodevelopmental perspective, these experiences carry the potential to cause disruptions and neurological scars because, in order to deal with highly stressful environments during development, individuals have to modify the psychological and neurological structure and function to adapt to these environments. The result of these disruptions and adaptations is what makes individuals more prone to developing certain types of psychopathology and symptoms 37 . Besides, these experiences generate intense stress reactions that, when repeated, lead individuals to become chronically stressed and overly vigilant, presenting an atypical cortisol regulation 35 .…”
Section: Resultsmentioning
confidence: 99%
“…The consequences of psychological stress exposure have been the focus of numerous studies (Galvan & Rahdar, 2013;Grassi-Oliveira, Ashy, & Stein, 2008;McEwen, 2012;Yehuda & Seckl, 2011). In addition, there is mounting evidence supporting that psychological stress might induce cognitive, emotional, and biological changes that resemble those elicited by physical stressors (Cirulli et al, 2009;Danese & McEwen, 2012;Dickerson & Kemeny, 2004).…”
Section: Traducción Y Adaptación Del Trier Social Stress Test Para Nimentioning
confidence: 99%