Psychoactive agents in dogs with bilateral lesions in subcortical structures

Goldstein, S.; Himwich, Williamina A.; Leiner, K.; Stout, Michael

doi:10.1212/wnl.21.8.847

Neurology

1971

DOI: 10.1212/wnl.21.8.847

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Psychoactive agents in dogs with bilateral lesions in subcortical structures

S. Goldstein¹,

Williamina A. Himwich²,

K. Leiner³

et al.

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1972

1973

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“…A reciprocal relationship between the levels of DA and 5-HT in the caudate has been proposed (7,8), and it has been shown that inhilbition of monoamine oxidase can upset the caudate biogenic amine balance by selectively elevating 5-HT levels (9,10). Furthermore, certain monoamine oxidase inhibitors are capable of inducing involuntary movements in experimentail animals ( 10,11).…”

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confidence: 99%

Analysis of Tremorgenic Effects of Intracaudate Serotonin,

Malseed

Baker

1973

Experimental Biology and Medicine

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Normal integrative functioning of the caudate neuroregulatory system appears to depend on critically balanced local neurotransmitter levels (1, 2). For example, caudate instability as reflected in the development of tremors has been ascribed to disturbances in a neurotmnsmi t ter balance, involving either augmented cholinergic excitation (3) or diminished dopaminergic inhibition (4). However, despite the presence of appreciable quantities of serotonin (5-HT) in the caudate nucleus ( 5 , 6), its potential role in the regulation of caudate neuronal excitability is undefined and its relationship to the major neurotransmitters acetylcholine ( ACh) and dopamine (DA) remains relatively undetermined.A reciprocal relationship between the levels of DA and 5-HT in the caudate has been proposed (7, 8), and it has been shown that inhilbition of monoamine oxidase can upset the caudate biogenic amine balance by selectively elevating 5-HT levels (9, 10). Furthermore, certain monoamine oxidase inhibitors are capable of inducing involuntary movements in experimentail animals ( 10, 11). On this basis, it seemed reasonable to test the hypothesis that 5-HT might participate in an intracaudate neuroregulatory system to influence local neuronal excitability and play a significant role in modifying caudate function. Since hindlimb tremor has been utihed by our group as an endpoint and sensitive index of disturbances in neurotransmitter functioning within the caudate, the present studies were structured to determine the direct effects of 5-HT on local caudate activity 1 Investigation s u p p~M by US. Public Health Serdce Gmnt MIH 08833 from N s~~s M~ Invtitute Mental Health.and to explore its relationship to the local effects of ACh and DA. Materials and Methods.Details of the neurosurgical procedure followed in preparing the chronic cats utilized in this study may be found in a previous report (3). In short, the technique involved stereotaxic impliantation of combined recording electrode-injection guides (injectrodes) into various blrain areas (12) including the caudate nucleus or L8, D+5) and substantia nigra (AG, Rg, or Ls, D--5). Bipolar twisted recording electrodes were positioned on the left and right frontal cortex, while 'it screw in the occipital portion of the skull served as the indifferent electrode. Insulated recording wires from each electrode were terminated in an Amphenol plug (series 2 23-1 2 17) permanently anchored to the skull. After a 2 wk recovery period, each cat was tested at intervals of 7-10 days. The animals were suspended in a canvas sling which permitted free movement of the left hind leg and a sensitive phonocartridge assembly (ASTATIC 13TB) was positioned on the dorsail surface of the left hindfoot. Tremor and local electrographic activity were simultaneously recorded on an electroencephalograph (Grass Model 6 ) . Tlremor parameters (frequency, amplitude, percentage tremor time, etc.) were semiquantitated and analyzed as previously described (3). Solutions of drugs were microinjected lomllly in volumes not...

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confidence: 99%

Analysis of Tremorgenic Effects of Intracaudate Serotonin,

Malseed

Baker

1973

Experimental Biology and Medicine

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Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine

1972

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Psychoactive agents in dogs with bilateral lesions in subcortical structures

Cited by 2 publications

References 0 publications

Analysis of Tremorgenic Effects of Intracaudate Serotonin,

Analysis of Tremorgenic Effects of Intracaudate Serotonin,

Reduced cataleptogenic effects of some neuroleptics in rats with lesioned midbrain raphe and treated with p-chlorophenylalanine

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