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Influence of prostaglandins E2 (PGE2) and F2alpha (PGF 2alpha) on multiplication of myxovirus parainfluenza 3 was investigated. At concentrations of 0.01--1 mug/ml prostaglandins had no direct cytotoxic effects. PGE2 and PGF2alpha inhibited multiplication of parainfluenza 3 virus at concentrations 0.1--10 mug/ml. The inhibitory effect was most pronounced when the prostaglandins were added to medium for the whole period of virus multiplication (48 hours) while little or no effect was found when prostaglandins were added before virus inoculation or for 2 hours after infection. It is suggested that prostaglandins exert an inhibitory effect on the replication phase of the virus by influencing the growth of the WISH cells.

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The effects of drugs influencing the function of extrapyramidal system: chlorpromazine (CPZ), halo peridol, amphetamine, and oxotremorine were checked in rats with lesioned MR or DR raphe areas and in animals pretreated with either p-CPA (p-chlorophenylalanine) or LSD, i.e. at impaired functions of the central serotoninergic system. Lesions of the raphe system and pretreatment with either p-CPA or LSD significantly diminished the cataleptogenic effects of both CPZ and haloperidol. The amphetamine-induced stereotyped behaviour was intensified in animals with raphe system lesions, whereas in rats pretreated with p-CPA or LSD the action of amphetamine was diminished. Rats with raphe system lesions showed no change in the tremorogenic action of oxotremorine. In animals pretreated with either p-CPA or LSD the onset of the oxotremorine tremor was even delayed. It is concluded that an intact and functionally unimpaired serotoninergic system is necessary for the cataleptogenic action of neuroleptics.