Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia’s Gut Feeling

Fakhfouri, Gohar; Mijailović, Nataša R.; Rahimian, Reza

doi:10.3390/cells13020177

Cited by 3 publications

(2 citation statements)

References 160 publications

(209 reference statements)

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“…Expanding on our previous analyses, we examined the overlap between IBD-associated genes and genes implicated in various brain disorders. There were many previous reports of comorbidities between IBD and neurological conditions (Fakhfouri G et al, 2024;Bernstein C et al, 2019). This analysis provides insights into the shared genetic architecture between these conditions.…”

Section: Common Genes Between Ibd and Neurological Disordersmentioning

confidence: 99%

Genetic Overlap Between Inflammatory Bowel Disease and Neurological Disorders: Insights from GWAS and Gene Expression Analysis

Tripathi,

Stern,

Dagan

et al. 2024

Preprint

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Inflammatory Bowel Disease (IBD), which includes Crohn’s disease (CD) and Ulcerative Colitis (UC), is a complex and multifactorial condition marked by chronic inflammation of the gastrointestinal tract. This study leverages genome-wide association studies (GWAS) and gene expression data from the Genotype-Tissue Expression (GTEx) project to investigate IBD’s genetic and expression profiles and subtypes. We examined 207 studies related to IBD, 71 specific to CD, and 66 focused on UC, identifying both shared and unique genetic factors among these conditions. GWAS meta-analysis revealed the top IBD-associated genes, which include IL23R, NOD2, ATG16L1, HLA-DRB9, and more. Pathway enrichment analyses identified consistently enriched pathways such as the NF-kappa B signaling pathway, JAK-STAT signaling pathway, and cytokine-cytokine receptor interaction, all of which play critical roles in immune responses and inflammation. Gene Ontology (GO) term analysis highlighted processes like cytokine production, cell activation, and leukocyte activation, reinforcing their involvement in the pathogenesis of IBD. Gene expression analysis showed that genes associated with IBD are expressed not only in the gastrointestinal tract but also in various regions of the brain, suggesting potential links between IBD and neurological functions. Our study further explored the genetic overlap between IBD and several neurological disorders, including schizophrenia, depression, autism spectrum disorder, and attention-deficit/hyperactivity disorder, uncovering a shared genetic architecture. These findings emphasize the systemic nature of IBD and its potential neurological implications, paving the way for targeted therapeutic strategies that address both gastrointestinal and neurological aspects of the disease.

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Section: Common Genes Between Ibd and Neurological Disordersmentioning

confidence: 99%

Genetic Overlap Between Inflammatory Bowel Disease and Neurological Disorders: Insights from GWAS and Gene Expression Analysis

Tripathi,

Stern,

Dagan

et al. 2024

Preprint

View full text Add to dashboard Cite

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“…Neutrophils play a crucial role in gut-brain inflammation, as they are involved in the immune response and can migrate from the gut to the brain [16]. Their migration is facilitated by the dysregulation of pathways during dysbiosis, leading to altered permeability of the blood-brain barrier (BBB).…”

Section: Role Of Neutrophils In Gut-brain Inflammationmentioning

confidence: 99%

Neutrophils in the Focus: Impact on Neuroimmune Dynamics and the Gut–Brain Axis

Krsek,

Baticic

2024

Gastrointestinal Disorders

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The growing field of gut–brain axis research offers significant potential to revolutionize medical practices and improve human well-being. Neutrophils have emerged as key players in gut–brain inflammation, contributing to the relocation of inflammatory cells from the gut to the brain and exacerbating neuroinflammation in conditions, such as inflammatory bowel disease and neurodegenerative diseases. The intricate network of molecular and functional connections that interlinks the brain with the gastrointestinal system is characterized by complex signaling pathways. Understanding the complex interplay among the microbiota, gut, and brain offers unparalleled opportunities to develop novel therapeutic interventions for neurological disorders and improve overall health outcomes. The aim of this review was to comprehensively summarize current knowledge and future perspectives regarding the multifaceted role of neutrophils and their impact on the neuroimmune dynamics in the context of the gut–brain axis.

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Inhibiting the activation of enteric glial cells alleviates intestinal inflammation and comorbid anxiety- and depressive-like behaviors in the ulcerative colitis mice

Li,

Wang,

Sun

et al. 2024

Neurochemistry International

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Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia’s Gut Feeling

Cited by 3 publications

References 160 publications

Genetic Overlap Between Inflammatory Bowel Disease and Neurological Disorders: Insights from GWAS and Gene Expression Analysis

Genetic Overlap Between Inflammatory Bowel Disease and Neurological Disorders: Insights from GWAS and Gene Expression Analysis

Neutrophils in the Focus: Impact on Neuroimmune Dynamics and the Gut–Brain Axis

Inhibiting the activation of enteric glial cells alleviates intestinal inflammation and comorbid anxiety- and depressive-like behaviors in the ulcerative colitis mice

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