Psychiatric care for a person with MELAS syndrome: A case report

Leong, Douglas Yeung; Chee, Rei Yen; Lui, Yit Shiang

doi:10.1002/ccr3.4146

Cited by 2 publications

(2 citation statements)

References 29 publications

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“…The best therapeutic response in comorbid depressive episodes has been achieved with the use of duloxetine, an SNRI antidepressant (Serotonin and Norepinephrine Reuptake Inhibitor), while other antidepressants have potentially serious side effects. The SSRI antidepressant sertraline demonstrates hepatotoxicity, and tricyclic antidepressants like anafranil and imipramine result in extrapyramidal symptoms and memory impairment 40 .…”

Section: Treatment Optionsmentioning

confidence: 99%

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Psychiatric aspects of the MELAS syndrome

Lačković

2023

Galenika Med J

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MELAS (Mitochondrial Encephalopathy Lactic Acidosis and Stroke-like episodes) syndrome is a condition characterized by mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes. It is a rare, inherited, neurodegenerative disorder caused by mitochondrial dysfunction that leads to energy production disturbances. The disease most commonly begins at a younger age, before the age of 40, with episodes resembling strokes, and psychiatric symptoms can also occur in the early stages of the disease. Later on, encephalopathy may develop, which is accompanied by epileptic seizures and/ or dementia. Psychiatric disorders in MELAS syndrome are present but insufficiently studied, which should be considered during diagnosis to prevent th disease from going unrecognized. Early diagnosis of any disease, including MELAS, is crucial as timely initiation of treatment significantly contributes to a more favorable course and better prognosis of the disease. When diagnosing MELAS, attention should be paid to the potential presence of psychiatric disorders.

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Section: Treatment Optionsmentioning

confidence: 99%

“…Valproic acid, indicated for controlling impulsivity, aggression, and epileptic seizures, can cause hepatotoxicity, steatosis, and encephalopathy. The best control of anxiety is achieved by using clomipramine and pregabalin 35,40 .…”

Section: Treatment Optionsmentioning

confidence: 99%