Psychiatric Aspects of Infertility

Becker, Mark P.; Chandy, Ann; Mayer, John R.; Sachdeva, Jyoti; Albertini, Elizabeth; Sham, Catherine C.; Worley, Linda L.M.

doi:10.1176/appi.ajp.2019.176702

Cited by 11 publications

(8 citation statements)

References 27 publications

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“…Depression usually affects couples trying to conceive, either directly or indirectly, although there are conflicting results regarding their effects on fertility. It is unclear whether pre-morbid diagnoses of depression contribute to infertility or whether they are caused by the psychological distress of infertility and its treatment ( 49 , 50 ). A cohort study indicated that male partners with active major depressive disorder were less likely to have a partner achieve conception.…”

Section: Discussionmentioning

confidence: 99%

A bidirectional causal relationship study between mental disorders and male and female infertility

Chen,

Hao,

Xie

et al. 2024

Front. Psychiatry

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BackgroundThe relation between mental disorders (MDs) and infertility can be reciprocal. But exactly which MD affects infertility remains controversial. Our aim was to use Mendelian randomization (MR) to explore bidirectional causality between 15 MDs and male infertility and female infertility.MethodsThe data of MDs, male infertility, and female infertility were derived from published genome-wide association studies (GWAS). The inverse variance weighted method was considered to be the main analytical approach. Sensitivity analysis was performed using MR-Egger, Cochran’s Q, radial MR, and MR-PRESSO tests.ResultsOur results found that mood disorders (OR, 1.4497; 95% CI, 1.0093 – 2.0823; P = 0.0444) and attention deficit hyperactivity disorder (OR, 1.3921; 95% CI, 1.0943 – 1.7709; P = 0.0071) were positively correlated with male infertility, but obsessive-compulsive disorder (OR, 0.8208; 95% CI, 0.7146 – 0.9429; P = 0.0052) was negatively associated with male infertility. For females, anorexia nervosa (OR, 1.0898; 95% CI, 1.0070 – 1.1794; P = 0.0329), attention deficit hyperactivity disorder (OR, 1.1013; 95% CI, 1.0041 – 1.2079; P = 0.0406), and major depressive disorder (OR, 1.1423; 95% CI, 1.0213 – 1.2778; P = 0.0199) increased risk of infertility. In reverse relationship, female infertility increased the incidence of bipolar disorder (OR, 1.0009; 95% CI, 1.0001 – 1.0017; P = 0.0281).ConclusionWe demonstrated the association between five MDs and male or female infertility. Female infertility was also found to be associated with an increased risk of one MD. We look forward to better designed epidemiological studies to support our results.

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Section: Discussionmentioning

confidence: 99%

A bidirectional causal relationship study between mental disorders and male and female infertility

Chen,

Hao,

Xie

et al. 2024

Front. Psychiatry

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“…A significant breakthrough was the commencement of studies of the metagenome based on sequencing 16S rRNA of micro-organisms inhabiting the vagina and the uterus [ 24 ]. It is important to remember that a healthy microbiome of the vagina and endometrium, in comparison to the microbiome of the digestive system, is relatively unvaried and is mostly colonized by Lactobacillus [ 1 , 2 ]. Nevertheless, Miles et al [ 25 ] and Winters et al [ 26 ] have shown that, in endometrium samples obtained during hysterectomy, the dominant bacteria are Acinetobacter , Pseudomonas , and Corynebacterium .…”

Section: Discussionmentioning

confidence: 99%

“…The inability to be a mother causes emotional problems for women, as well as anxiety, which greatly hinders becoming pregnant and maintaining pregnancy. The inability to conceive a child is, naturally, a serious problem when it comes to the woman’s psyche, and, in many cases, having a child is a sign of personal fulfillment [ 2 , 3 , 4 ]. Moving away from the social and mental aspects of infertility, it is important to point out that the physical health of a woman is key in the fertilization process.…”

Section: Introductionmentioning

confidence: 99%

Marking the Profile of the Microflora of the Endometrium and Uterine Cervix in Women as a Potential Factor Determining the Effectiveness of In Vitro Fertilization

Bednarska-Czerwińska

Czerwiński

Morawiec

et al. 2022

JCM

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One promising research trend involves evaluating the influence of microbiota in the reproductive system of women on becoming pregnant and maintaining pregnancy. The goal of this study was to define the microflora profile of the endometrium and uterine cervix in women qualified for an in vitro fertilization (IVF) procedure, which is expected to contribute to increasing the percentage of successful IVF implantations. Based on the conducted molecular analysis in the collected swabs, 22 bacterial strains were identified. Eleven strains (57%) that were isolated belong to the physiological microflora, the most common strain of which was Lactobacillus. Eight of the isolated strains (33%) were pathological microflora, among which the most common bacteria were from the Enterobacteriaceae family (which includes E. coli, Shigella, and Salmonella). Finally, three of the bacterial strains (10%) may be a component of both physiological or pathological microflora of the vagina: Bifidobacterium breve, Bifidobacterium longum group, and Alloscardovia omnicolens. The presence of Escherichia coli was detected in six women, Staphylococcus aureus also in six patients, Atopobium parvulum in three, Streptococcus salivarius group in three, Enterococcus faecalis in four, and Aerococcus christensenii in two patients. We found statistically significant relationships (p < 0.05) between Lactobacillus fermentum and Enterococcus faecalis, Lactobacillus delbrueckii and Escherichia coli groups, Lactobacillus FN667084_s and Staphylococcus aureus groups, as well as Lactobacillus fermentum and Streptococcus agalactiae. Based on the conducted study, it may be confirmed that the endometrium is, to a large extent, colonized by lactic acid bacilli. Apart from that, endometrial dysbiosis was not noted in patients qualified for the IVF procedure.

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“…The prevalence of such disorders appear to be rather significant among infertile women: research findings show that 40% of that segment meet the criteria for a psychiatric diagnosis. The most widespread diagnosis points to anxiety disorders, major depressive disorder and dysthymia [6]. An increased risk of suicidal ideation has been reported in women who suffer from infertility (e.g., a 9.4% incidence), although a direct correlation is still undetermined [7].…”

Section: The Mental and Emotional Toll Of Female Infertilitymentioning

confidence: 99%

ART Innovations: Fostering Women’s Psychophysical Health between Bioethics Precepts and Human Rights

et al. 2021

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Infertility is a highly relevant global issue affecting the reproductive health of at least 15% of reproductive-aged couples worldwide. The scope and severity of the infertility problem is even more prevalent in developing countries, mostly due to untreated reproductive tract infections (RTIs). Infertility, however, goes beyond the mere inability to procreate, but brings about profound psychological, social, and ethical implications of enormous magnitude. In vitro fertilization (IVF) and other assisted reproduction technologies (ARTs) have gradually become widespread therapeutic options. After all, the implementation of medically assisted reproductive procedures in order to overcome infertility is in keeping with the tenets of the reproductive rights agenda laid out at the International Conference on Population and Development (ICPD) in Cairo in 1994. Nonetheless, concerns still linger about how to implement and regulate such interventions in an ethically tenable fashion. The unremitting pace at which such techniques develop have upset the very notion of sexuality relating to reproduction as well as the concept of family itself. That rift risks causing a crisis in terms of bioethics sustainability and enforcement, which is bound to happen when science and innovation outpace the bioethical precepts on which we rely for essential guidance in medical practice. The authors argue in favor of an approach to regulation and policy-making that puts on the forefront a thorough assessment as to potential risks that such interventions might entail for foundational bioethics principles and inalienable human rights.

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Psychiatric Aspects of Infertility

Cited by 11 publications

References 27 publications

A bidirectional causal relationship study between mental disorders and male and female infertility

A bidirectional causal relationship study between mental disorders and male and female infertility

Marking the Profile of the Microflora of the Endometrium and Uterine Cervix in Women as a Potential Factor Determining the Effectiveness of In Vitro Fertilization

ART Innovations: Fostering Women’s Psychophysical Health between Bioethics Precepts and Human Rights

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