Psychiatric and Psychosocial Outcome of Orthotopic Liver Transplantation

Abstract

Background:The study aimed to explore the prevalence of psychiatric disorders among orthotopic liver transplantation (OLT) recipients, and to investigate how psychiatric morbidity was linked to health-related quality of life (HRQOL). Methods: We recruited 75 patients who had undergone OLT a median of 3.8 years previously (range = 5-129 months). Psychiatric morbidity was assessed using the Structural Clinical Interview for the DSM-III-R. Psychometric observer-rating and self-rating scales were administered to evaluate cognitive functioning (SKT), depressive symptomatology (HAMD 17 ), posttraumatic stress symptoms (PTSS-10), social support (SSS), and HRQOL (SF-36 Health Status Questionnaire). Treatment characteristics were obtained from medical records. Results: 22.7% (n = 17) of our sample had a current or probable psychiatric diagnosis according to DSM-III-R: 2.7% full posttraumatic stress disorder (PTSD) (n = 2), 2.7% major depressive disorder (MDD) comorbid to full PTSD (n = 2), 1.3% MDD comorbid to partial PTSD (n = 1), and 16% partial PTSD (n = 12). Patients with PTSD symptoms demonstrated lower cognitive performance, higher severity of depressive symptoms and more unfavorable perception of social support. OLT-related PTSD symptomatology was associated with maximal decrements in HRQOL. The duration of intensive care treatment, the number of medical complications, and the occurrence of acute rejection were positively correlated with the risk of PTSD symptoms subsequent to OLT. Conclusion: OLT-related PTSD symptomatology impairing HRQOL is a complication for a subgroup of OLT recipients. Health-care providers should be aware of the possible presence of PTSD in OLT survivors.

The Psychsocial Status Of Liver Transplant Patient And Their Relatives On The Effect Of Quality Of Life

“…TSSB belirtileri olan hastaların daha düşük bilişsel performans sergiledikleri, depresif bulguların daha şiddetli olduğunu ve bu durumun sosyal yaşamdan izolasyona sebep olduğu belirlenmiştir. [18] Ülkemizde karaciğer nakilli hastaların yaşam kalitesi ve ruhsal durumu ile ilgili yapılmış bir ça-lışmaya ulaşılamamıştır. Böbrek nakli olan hastalarda yapıl-mış çalışmalara bakıldığında, Sağduyu ve ark.…”

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“…Viename tyrime nustatyta, kad PTSS dažnis po kepenų transplantacijos siekė 4 proc., o dalinės PTSS (atitinkančios dalį diagnostinių kriterijų) -16 proc. [34].…”

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