Psoriasis: una enfermedad cutánea relacionada con riesgo cardiovascular elevado

González-Vela, Carmen; González‐Juanatey, Carlos

doi:10.1016/j.ad.2012.01.006

Cited by 13 publications

(3 citation statements)

References 24 publications

(31 reference statements)

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“…In keeping with these findings, we and others have recently demonstrated that patients with HS have an increased prevalence of subclinical atherosclerosis, which persists even after adjusting for classic CV risk factors [ 13 , 14 ]. These observations suggest that HS itself may be an independent risk factor for atherosclerotic CV disease, and support the hypothesis that, as well as in other chronic inflammatory conditions [ 15 – 17 ], the persistent systemic inflammation may be crucial to explain the premature and accelerated atherogenesis in this disorder.…”

Section: Introductionsupporting

confidence: 78%

Carotid ultrasound is useful for the cardiovascular risk stratification in patients with hidradenitis suppurativa

et al. 2018

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Section: Introductionsupporting

confidence: 78%

Carotid ultrasound is useful for the cardiovascular risk stratification in patients with hidradenitis suppurativa

et al. 2018

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“…It is responsible for considerable psychosocial disability and negative effects on quality of life 1–5. The increased prevalence of risk factors of cardiovascular diseases, such as metabolic syndrome, diabetes, obesity, hypercholesterolemia, hypertension, and endothelial dysfunction, among psoriatic patients was described in several studies 5,6,9,11,38,39. This was confirmed by a meta-analysis published by Miller et al6 According to Mehta et al, severe psoriasis is responsible for an additional 6.2% absolute risk of a 10-year rate of major adverse cardiac events 40.…”

Section: Discussionmentioning

confidence: 99%

<p>Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?</p>

Németh¹,

Péter²,

Boncz³

et al. 2019

TCRM

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Purpose Psoriasis is one of the most common lifelong lasting dermatologic diseases. According to the latest studies, psoriatic patients have a higher risk of developing cardiovascular diseases. Psoriasis is considered as a systemic inflammatory disease. Several oxidative stress markers have been shown to be elevated in psoriasis. However, a panel of biomarkers has not been used yet. This study was aimed at exploring the connection between a panel of biomarkers (C-reactive protein, asymmetric dimethylarginine, uric acid, total antioxidant capacity, malondialdehyde, and orosomucoid [ORM]) and cardiovascular risk in psoriatic patients. Patients and methods The inclusion criterion was the onset of psoriasis with skin lesions. Exclusion criteria were impaired renal function (eGFR<60 mL/min/1.73 m 2 ), acute inflammations (urinary, respiratory, skin inflammation, etc), autoimmune disorders (rheumatoid arthritis, systemic lupus erythematosus, or inflammatory bowel disease), and any kind of biological antipsoriatic treatment. Patients with a medical history of myocardial infarction, coronary heart disease, stroke, transient ischemic attack, and carotid artery stenosis were also excluded. Biomarkers were measured by routine procedures, ELISA and HPLC. QRISK®2-2017 was used to assess 10-year risk of cardiovascular disease development. Psoriasis severity was measured by the Psoriasis Area and Severity Index. Results One hundred and fourteen psoriatic patients were enrolled. Only urinary orosomucoid and urinary orosomucoid/urinary creatinine (u-ORM/u-CREAT) ratio showed significant correlation with QRISK score (u-ORM, r=0.245; u-ORM/u-CREAT, r=0.309). When comparing mild psoriatic patients to moderate psoriatic patients, significant differences could only be found in u-ORM and u-ORM/u-CREAT ratio. Conclusion There seems to be a connection between urinary ORM and cardiovascular risk. U-ORM and u-ORM/u-CREAT ratio could be used as an indicator of low-grade inflammation in mild and moderate psoriasis. However, it is the 10-year follow-up of cardiovascular events that will determine the usefulness of this biomarker panel.

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“…The pro-inflammatory molecules released during chronic inflammation may lead to the presence of one or more disorders co-occurring with psoriasis, such as atherosclerosis, atherogenesis, insulin resistance, hypertension, obesity, dyslipidemia, metabolic syndrome, and diabetes mellitus type 2 2 3 . As the psoriasis area severity index (PASI) score increases, the risk of these accompanying disorders also increases 4 5 . Obesity triggers inflammatory changes in the body.…”

Section: Introductionmentioning

confidence: 99%

Association of Adipokines, Insulin Resistance, Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris

et al. 2016

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BackgroundSystemic inflammation in psoriasis causes insulin resistance and cardiovascular diseases. Adipokines are adipose-tissue-derived factors that are involved in metabolic processes. It is thought that these adipokines are associated with the development of psoriasis.ObjectiveThe purpose of this study was to determine the changes in adipokine levels, insulin resistance, hypertension, and dyslipidemia over a 12-week period.MethodsThe study comprised 35 psoriasis patients and 50 controls. Blood samples were obtained twice from the patients, one sample at the start and one at the end of a 12-week follow-up period. The following parameters were assessed in both groups: serum fasting glucose, fasting insulin, homeostasis model assessment-estimated insulin resistance (HOMA-IR) index, serum lipids, adiponectin, leptin, resistin, chemerin, omentin, vaspin, visfatin, retinol-binding protein 4, and high-sensitivity C-reactive protein (hs-CRP) levels; blood pressure; body mass index; and the psoriasis area severity index (PASI) scores.ResultsThe patients showed an improvement in the PASI score and a significant decrease in serum hs-CRP, omentin, and chemerin values. Moreover, at the start of the follow-up, the psoriasis patients had significantly lower levels of adiponectin and visfatin and significantly higher levels of vaspin and resistin than those of the control group. Visfatin levels correlated negatively with low-density lipoprotein (LDL) and cholesterol, while vaspin and omentin levels correlated positively with diastolic blood pressure. Decreased adiponectin levels correlated negatively with diastolic blood pressure and LDL.ConclusionPlasma levels of adipokines might be useful for evaluating the disease activity of psoriasis and its comorbidities.

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Psoriasis: una enfermedad cutánea relacionada con riesgo cardiovascular elevado

Cited by 13 publications

References 24 publications

Carotid ultrasound is useful for the cardiovascular risk stratification in patients with hidradenitis suppurativa

Carotid ultrasound is useful for the cardiovascular risk stratification in patients with hidradenitis suppurativa

<p>Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?</p>

Association of Adipokines, Insulin Resistance, Hypertension and Dyslipidemia in Patients with Psoriasis Vulgaris

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