Psoriasis predisposition and occupational triggering factors in the appraisal of occupational medical expertises

Mahler, Vera; Diepgen, Thomas L.; Skudlik, Christoph; Becker, Detlef; Fartasch, Manigé; Geier, Johannes; Häberle, M.; Hillen, Uwe; Krohn, Steffen; John, Swen Malte; Weißhaar, Elke; Werfel, Thomas; Zagrodnik, Fred

doi:10.1111/ddg.12262_1

Cited by 6 publications

(10 citation statements)

References 27 publications

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“…Psoriasis was included in the analyses since it has been shown to be a common cause of DP for skin disease in previous studies (2). Psoriasis constitutes a minor, but well-documented, group of occupational dermatoses, and prevalences of 1.2-5.6% have been reported in various clinical study populations (10,11). Interestingly, in our study we found comparable IRs for psoriasis and eczema in cement workers and painters, which indicates that psoriasis also has a negative impact on work ability.…”

Section: Discussionsupporting

confidence: 70%

“…The IR due to psoriasis in plumbers was nearly twice the rate due to eczema and was also more prominent at younger ages (Tables II and III). Psoriasis is currently viewed as a systemic disorder with skin symptoms, potential joint involvement and comorbidities (11). Occupational skin symptoms related to psoriasis are localized mainly on the hands.…”

Section: Discussionmentioning

confidence: 99%

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Disability Pensions due to Skin Diseases: A Cohort Study in Swedish Construction Workers

Meding¹,

Wrangsjö²,

Burdorf³

et al. 2016

Acta Derm Venerol

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Disability pensions due to skin diseases in Swedish male construction workers were studied by linking data from pension registers and an occupational health service. Incidence rates of disability pensions for cement workers, painters and plumbers were compared with 2 control groups. A total of 623 disability pensions were granted during 4 decades of follow-up. The main diagnoses were eczema (36%) and psoriasis (49%). Pensions were mostly granted in the age range 55-64 years. Among painters, cement workers and plumbers the incidence rates for disability pensions were 33.3, 24.5 and 20.4 cases/100,000 person-years, respectively, compared with 13.7 and 9.2 cases/100,000 person-years in control groups. Relative risks were highest for eczema, and were notable for psoriasis. Attributable fractions for eczema were 90% in cement workers and painters and 75% in plumbers compared with control groups. Attributable fractions for psoriasis in the occupational groups studied were in the range 54-67%. In conclusion, eczema and psoriasis have a high impact on loss of work ability, as reflected by disability pensions.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Disability Pensions due to Skin Diseases: A Cohort Study in Swedish Construction Workers

Meding¹,

Wrangsjö²,

Burdorf³

et al. 2016

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

“…It can be speculated, that predisposed patients with psoriasis can develop ACD and subsequently manifestation of EIP. If its development is work-related and lead to aggravation of constitutional disease (here psoriasis), an occupational disease may be assessed (13). It should be further examined, if IgE elevation, which was frequently observed in EIP patients, contributes to the development of contact sensitization (14).…”

Section: Discussionmentioning

confidence: 99%

Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization

Kolesnik

Franke²,

Lux³

et al. 2018

Acta Derm Venerol

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Differential diagnosis of palmoplantar non-pustular psoriasis and chronic allergic contact dermatitis (ACD) and the combination of these conditions, termed "eczema in psoriatico" (EIP), is difficult, especially in cases of isolated involvement. A blind re-evaluation of 63 archived formalin-fixed palmoplantar samples, previously diagnosed clinically as either psoriasis or chronic ACD, was performed. Samples were allocated to histopathological diagnoses of psoriasis, contact dermatitis or EIP. Immunohistological stainings were performed for better characterization. Immunochemistry of EIP revealed features that overlapped contemporarily with psoriasis (cytokeratin 17 (CK17), Ki67, interleukin (IL)-8, IL-17, IL-23) and with ACD (CD1a, major histocompatibility complex (MHC) class I, MHC class II, epidermal T-cell subsets). Surprisingly, a significantly much higher number of dermal CD8+ T cells was found in EIP than in ACD and psoriasis. In conclusion, this study provides insight into the immunohistological differentiation of palmoplantar psoriasis, chronic ACD and EIP.

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“…Since different countries have different legislation as to dealing with predispositions, there are consequently also remarkable differences in the international literature. Under German law, for example, the individual insured person's status is protected as is at the commencement of the harmful work‐related activity . This protection comprises all disease predispositions and constitutional impairments, including also the genetic predisposition for atopic eczema or psoriasis of the hands.…”

Section: Resultsmentioning

confidence: 99%

Occupational skin diseases: actual state analysis of patient management pathways in 28 European countries

Mahler

Aalto‐Korte

Alfonso

et al. 2017

Acad Dermatol Venereol

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Psoriasis predisposition and occupational triggering factors in the appraisal of occupational medical expertises

Cited by 6 publications

References 27 publications

Disability Pensions due to Skin Diseases: A Cohort Study in Swedish Construction Workers

Disability Pensions due to Skin Diseases: A Cohort Study in Swedish Construction Workers

Eczema in Psoriatico: An Important Differential Diagnosis Between Chronic Allergic Contact Dermatitis and Psoriasis in Palmoplantar Localization

Occupational skin diseases: actual state analysis of patient management pathways in 28 European countries

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