Psoriasis Associated With Selective IgA Deficiency

Clinical management of coeliac disease

“…Several studies have indicated a link between SIgAD and autoimmune diseases [154–166]. Although it is more common that SIgAD is diagnosed as part of the screening for CD [167], physicians managing SIgAD patients should be aware of the association with CD [165, 166, 168, 169].…”

IgA Deficiency and Psoriasis: Relevance of IgA in the Pathogenesis of Psoriasis

“…A consistent observation by various groups is the correlation between increased serum levels of IgA and the extent of the skin manifestations and severity of arthritis [18,25]. However, it has been reported that pso riasis with arthropathy may coexist with a selective IgA deficiency [26], Two groups have reported on decreased IgA levels in psoriatic patients [27,28], The correlation between disease activity and IgA levels [18,25] suggests that IgA is of significance in the pathogenesis of psoriasis. It is attractive to hypothesize that IgA is an 'antipsoriatic factor.…”

“…Indeed, relatively high levels of IgA have been measured in chronic long-standing plaque psoriasis and in patients with extensive lesions, in contrast to the low levels of IgA in relapsing and guttate-type psoriasis |18|. Patients with decreased or undetectable IgA levels and psoriasis [26][27][28] may have an unfavorable prognosis according to this hypothesis.…”