IgA Deficiency and Psoriasis: Relevance of IgA in the Pathogenesis of Psoriasis

Kerkhof, P.C.M. van de; Steijlen, P.M.

doi:10.1159/000246487

Cited by 11 publications

(9 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aetiopathogenesis of this dermatosis is complex and not yet well known. In recent years, attention has been paid to probability of primary intestinal absorption disorders in psoriatics 1 and to IgA protective role 2 . It has also been observed that psoriasis can coexist with clinically asymptomatic celiac disease and a gluten‐free diet helps to obtain remission, even in patients with very chronic lesions 3–5 .…”

Section: Introductionmentioning

confidence: 99%

Serologic markers of celiac disease in psoriatic patients

Damasiewicz-Bodzek¹,

Wielkoszyński

2008

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Serologic markers of celiac disease in psoriatic patients

Damasiewicz-Bodzek¹,

Wielkoszyński

2008

Acad Dermatol Venereol

View full text Add to dashboard Cite

show abstract

“…In the present study the only girl with IgA deficiency had psoriasis. This might be a coincidence, but such a combination has previously been reported, and it is possible that IgA deficiency predisposes to the development of this disorder [26]. …”

Section: Discussionmentioning

confidence: 96%

Population-Based Screening for Selective Immunoglobulin A (IgA) Deficiency in Lithuanian Children Using a Rapid Antibody-Based Fingertip Test

et al. 2016

View full text Add to dashboard Cite

BackgroundSelective immunoglobulin A (IgA) deficiency is the most common inherited immunodeficiency disorder world-wide. An early diagnosis is advocated because of the increased risk of infections, autoimmune diseases, and allergic reactions. We investigated the usefulness of a rapid point-of-care test in detecting for IgA deficiency in a population with a previously unknown prevalence.Material/MethodsAltogether, 1000 children aged 11–13 years from randomly selected Lithuanian schools were enrolled. A point-of-care test with a fingertip sample was used to screen for the presence of IgA deficiency in children whose parents gave consent. Those with suspected IgA deficiency were referred to hospital for further clinical examination and confirmation of the diagnosis. In addition, their medical histories were compared with those of 30 age- and sex-matched healthy controls.ResultsIgA deficiency was suspected in one girl and in three boys on the basis of the rapid test, and the diagnosis was confirmed for all four cases (prevalence 0.4%, 95% confidence interval 0.16–1.02%). There was no difference in disease history or complications between IgA-deficient children and healthy controls.ConclusionsThe rapid antibody test is a practical and accurate method to diagnose selective IgA deficiency in children. The prevalence of IgA deficiency among Lithuanian schoolchildren is 1:250.

show abstract

“…Both systemic and organ-specific AD have been reported in IgAD, including autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura (Cunningham-Rundles, 2002), dermatomyositis (Claman et al, 1970), Henoch-Schonlein purpura (Martini et al, 1985), pernicious anemia (Spector, 1974;Kätkä et al, 1988), psoriasis (van de Kerkhof and Steijlen, 1995), primary biliary cirrhosis (James et al, 1986), and vitiligo (Torrelo et al, 1992). Associations of IgAD with common systemic AD are summarized in Table 1.…”

Section: Autoimmunitymentioning

confidence: 99%