Psoriasis and Risk of Mental Disorders in Denmark

Leisner, Michelle Z; Riis, Jette Lindorff; Schwartz, Sara; Iversen, Lars; Østergaard, Søren Dinesen; Olsen, Morten

doi:10.1001/jamadermatol.2019.0039

Cited by 34 publications

(42 citation statements)

References 6 publications

(18 reference statements)

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“…Thereafter, 25 studies were thought to be eligible and evaluated for full-text review. Sixteen studies were excluded, and the nine remaining studies (Abuabara et al, 2010;Feldman et al, 2015;Chen et al, 2018;Mitchell et al, 2018;Pezzolo et al, 2018;Huang et al, 2019;Leisner et al, 2019;Lin et al, 2019;Kim et al, 2020) were included. The search strategy and study selection are shown in Figure 1.…”

Section: Characteristics Of the Pooled Studiesmentioning

confidence: 99%

“…Of the nine studies, four were conducted in East Asia (Chen et al, 2018;Huang et al, 2019;Lin et al, 2019;Kim et al, 2020), three in Europe (Abuabara et al, 2010;Pezzolo et al, 2018;Leisner et al, 2019), and two in the USA (Feldman et al, 2015;Mitchell et al, 2018). Five were cohort studies (Abuabara et al, 2010;Pezzolo et al, 2018;Huang et al, 2019;Leisner et al, 2019;Kim et al, 2020); two were case-control studies (Chen et al, 2018;Lin et al, 2019); one was a cross-sectional study (Mitchell et al, 2018), and the remaining one was a retrospective study (Feldman et al, 2015). Almost all the studies used the codes of the International Statistical Classification of Diseases and Related Health Problems as a diagnostic basis.…”

Section: Characteristics Of the Pooled Studiesmentioning

confidence: 99%

“…Three studies (Pezzolo et al, 2018;Huang et al, 2019;Lin et al, 2019;Kim et al, 2020) had a modest risk of bias. One study (Leisner et al, 2019) had a high risk with scores of 2 points ( Table 2). Only one study had a cross-sectional design.…”

Section: Risk Of Biasmentioning

confidence: 99%

“…Seven studies (Feldman et al, 2015;Chen et al, 2018;Mitchell et al, 2018;Pezzolo et al, 2018;Huang et al, 2019;Leisner et al, 2019;Kim et al, 2020) that involved a total of 3,638,487 participants were included in the meta-analysis. We first analyzed the cases of dementia in all the patients, with and without psoriasis.…”

Section: Primary Outcomesmentioning

confidence: 99%

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Association Between Psoriasis and Dementia: Current Evidence

Liu

Chen

Li³

et al. 2020

Front. Aging Neurosci.

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Background: Psoriasis and dementia are both inflammatory diseases. The association between psoriasis and dementia has rarely been investigated, and the existing results are conflicting. Thus, we conducted this study to evaluate whether an association exists between psoriasis and dementia. Methods: We searched for studies from six databases from inception to July 30, 2020, using subject and free words. RevMan 5.4 was used to calculate the risk ratio (RR) of dementia in the subjects with psoriasis. When heterogeneity was present, a random-effects model was used. Subgroup, sensitivity, and meta-regression analyses were performed using Stata 15.1. Results: Nine studies were identified and included in the study, of which seven that involved a total of 3,638,487 participants were included in the meta-analysis. We found that among the patients with psoriasis (RR: 1.14, 95% confidence interval [CI]: 1.06-1.24, p = 0.0009) and psoriatic arthritis (RR: 2.20, 95% CI: 1.29-3.78, p = 0.004), the proportions of those with non-vascular dementia (RR: 1.13, 95% CI: 1.11-1.15, p < 0.00001) and vascular dementia (RR: 1.41, 95% CI: 1.09-1.82, p = 0.009) were higher than that among the patients without psoriasis. Those with dementia were also more likely to develop psoriasis, and those with severe psoriasis were less likely to die from dementia (RR: 1.88, 95% CI: 0.72-4.90, p = 0.020). The meta-regression analysis did not show any significant sources of heterogeneity. Conclusions: The patients with psoriasis and psoriatic arthritis show high prevalence of different types of dementia. Based on the findings of this study, dementia may not be considered a high-risk factor of death from severe psoriasis. However, identification of this potential risk allows for early intervention, thereby reducing comorbidities and deaths.

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Section: Characteristics Of the Pooled Studiesmentioning

confidence: 99%

Section: Characteristics Of the Pooled Studiesmentioning

confidence: 99%

Section: Risk Of Biasmentioning

confidence: 99%

Section: Primary Outcomesmentioning

confidence: 99%

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Association Between Psoriasis and Dementia: Current Evidence

Liu

Chen

Li³

et al. 2020

Front. Aging Neurosci.

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“…Psoriasis is a chronic, proliferative autoimmune skin disease governed by various genetic factors and stimulated by multiple environmental factors with a global prevalence of 2 − 3% [1,2]. The characteristic skin lesions in psoriasis are red papules or plaques covered with several layers of accumulated silverwhite scales that can be at a level higher than the skin surface.…”

Section: Introductionmentioning

confidence: 99%

Exploration of the Regulatory Effects of PSORI-CM01 and Yin Xie Ling on microRNAs in the Peripheral Blood Monocytes of Patients with Blood Stasis Syndrome of Psoriasis Vulgaris

Qi²,

et al. 2020

Preprint

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Background: Traditional Chinese medicines (TCMs) have been used to manage psoriasis since thousands of years and are associated with advantages such as long remission period and few side effects. PSORI-CM01 is a clinical TCM formula for treating the blood stasis syndrome of psoriasis vulgaris. It is optimised from Yin Xie Ling, a herbal preparation formulated by the Chinese national medical master Xuan Guowei. In the present study, we used microRNA (miRNA) chip technology to analyse the effects of PSORI-CM01 and Yin Xie Ling on miRNA differential expression in the peripheral blood monocytes of patients with blood stasis syndrome of psoriasis vulgaris.Methods: Blood samples collected from healthy subjects and patients with blood stasis syndrome of psoriasis vulgaris were obtained from the Department of Dermatology in the Guangdong Provincial Hospital of Chinese Medicine. These samples were obtained before and after treatment with PSORI-CM01 or Yin Xie Ling. Differentially expressed miRNAs were analysed by performing miRNA expression microarray to evaluate the mechanisms underlying the effects of the two formulations.Results: It was found that hsa-miR-3184-3p, hsa-miR-3653-3p, hsa-miR-20a-3p, hsa-miR-5681b, and hsa-miR-26a-5p were differentially expressed between the PSORI-CM01 and healthy control groups as well as between the Yin Xie Ling and healthy control groups before treatment, without any significant differences in their expression after treatment. The results revealed that the therapeutic effect of PSORI-CM01 on psoriasis was mediated mainly via the regulation of the adherens junction, thyroid hormone signalling, and proteoglycans in cancer pathways, whereas that of Yin Xie Ling was mediated mainly via the regulation of the endoplasmic reticulum protein processing, Hippo signalling, adherens junction, thyroid hormone signalling, cell cycle, proteoglycans in cancer, p53 signalling, oocyte meiosis, and unsaturated fatty acid biosynthesis pathways.Conclusions: The findings demonstrate that PSORI-CM01 and Yin Xie Ling are beneficial for treating blood stasis syndrome of psoriasis vulgaris through the regulation of hsa-miR-20a-3p and hsa-miR-3184-3p expression and, consequently, through the adherens junction, thyroid hormone signalling, and proteoglycans in cancer pathways.Trial registration: Registration number, ChiCTR-TRC-14005185; Date of registration, 8 August 2014.

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Exploring Mental Disorders in Patients With Skin Diseases

Armstrong

2019

JAMA Dermatol

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Psoriasis and Risk of Mental Disorders in Denmark

Abstract: Nijsten T, Meads DM, de Korte J, et al. Cross-cultural inequivalence of dermatology-specific health-related quality of life instruments in psoriasis patients.

Cited by 34 publications

References 6 publications

Association Between Psoriasis and Dementia: Current Evidence

Association Between Psoriasis and Dementia: Current Evidence

Exploration of the Regulatory Effects of PSORI-CM01 and Yin Xie Ling on microRNAs in the Peripheral Blood Monocytes of Patients with Blood Stasis Syndrome of Psoriasis Vulgaris

Exploring Mental Disorders in Patients With Skin Diseases

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