Psoriasis and risk of incident myocardial infarction, stroke or transient ischaemic attack: an inception cohort study with a nested case-control analysis

Brauchli, Yolanda B.; Jick, Susan S.; Miret, Montserrat; Meier, Christoph

doi:10.1111/j.1365-2133.2008.09020.x

Cited by 177 publications

(180 citation statements)

References 49 publications

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“…73 A recent inception cohort study with nested case-control analysis identified an increased risk of incident MI in patients less than 60 years old with severe disease, but failed to detect increases in strokes or TIA. 74 Similarly, in the Netherlands, patients with psoriasis did not have increased hospitalizations from ischemic heart disease. 75 To the contrary, in China, there was a higher odds ratio for the development of MI for mild and severe psoriasis, even after adjusting for age, sex, DM, HTN, hyperlipidemia, smoking and systemic therapies.…”

Section: -mentioning

confidence: 95%

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

et al. 2011

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Section: -mentioning

confidence: 95%

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

et al. 2011

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“…A modestly increased prevalence of MI was observed in both psoriasis and PsA patients, which varied with age 11,12 and psoriasis severity. 11,13,14 It remained significantly elevated after controlling for major cardiovascular risk factors.…”

Section: Cardiovascular Morbidity and Mortalitymentioning

confidence: 94%

Psoriasis, cardiovascular events, cancer risk and alcohol use: evidence‐based recommendations based on systematic review and expert opinion

Richard

Barnetche²,

Horreau

et al. 2013

Acad Dermatol Venereol

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The relationship between psoriasis, chronic inflammation, cardiovascular risk and risk of cancer has long been debated.In addition, it has been suggested that alcohol consumption may be a risk factor for psoriasis onset and severity.The aim of this study was to develop evidence-based recommendations on the risk of comorbidities and its management for daily clinical use, focusing on cardiovascular risk, risk of cancer and alcohol use in psoriasis.A scientific committee identified and selected through the Delphi method clinically relevant questions about cardiovascular risk, risk of cancer and alcohol use in psoriasis. To address these questions, a systematic literature search was performed in Medline, Embase and the Cochrane Library databases. Systematic literature reviews including meta-analysis whenever possible were performed. Subsequently, an Expert board meeting involving 39 dermatologists took place to analyse the evidence and to elaborate recommendations on the selected questions. Recommendations were graded according to the Oxford level of evidence grading system. The degree of agreement of these recommendations was assessed on a 10-point scale, as well as their potential impact on daily clinical practice.A total of 3242 articles were identified through the systematic literature searches, among which 110 were included in the systematic reviews. Overall, 12 recommendations were elaborated regarding comorbidities management in psoriasis patients. A moderate increased risk of cardiovascular diseases (CVD), mainly myocardial infarction (MI) [meta-analysis of cohort studies: OR = 1.25 (95% CI 1.03-1.52) and of cross-sectional studies: OR = 1.57 (95% CI 1.08-2.27)], and coronary artery disease (CAD) [meta-analysis of cross-sectional: OR = 1.19 (95% CI 1.14-1.24), of cohort studies: OR = 1.20 (95% CI 1.13-1.27) and of case-control studies: OR = 1.84 (95% CI 1.09-3.09)] was acknowledged. This increased cardiovascular risk requires appropriate prevention measures. There was a lack of substantial evidence that conventional systemic treatment has any effect on cardiovascular risk although methotrexate might be cardioprotective. An increased risk of solid cancer potentially associated with smoking and alcohol use was identified. The role of systemic treatment on cancer risk could not be assessed thoroughly due to limited long-term follow-up data. A higher risk of non-melanoma skin cancers especially squamous cell carcinoma was shown, mainly due to previous exposure to oral 8-methoxypsoralen-ultraviolet-A (PUVA), ciclosporin and possibly methotrexate. No firm conclusion could be drawn regarding alcohol and psoriasis due to high variability in alcohol usage assessment in studies. Clinical experience suggests higher alcohol consumption among psoriasis patients compared to the general population. The mean expert participants' level of agreement on these recommendations varied from 6.8 to 9.4. These 12 recommendations are evidence based and supported by a panel of expert dermatologists. The next step is now to dis...

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“…A descriptive cohort study has newly shown that patients with psoriasis had higher risks of incident myocardial infarction, angina, atherosclerosis, peripheral vascular disease, and stroke (5). Additionally, the prevalence of MI is higher in mild and severe psoriasis than in patients without psoriasis (29,30). There have been studies which have connected psoriasis to metabolic syndrome (31)(32)(33)(34).…”

Section: Relationship Between Psoriasis and Cardiovascular Diseasesmentioning

confidence: 99%

The Association Between Psoriasis and Cardiovascular Diseases

Kalkan

Karadağ

2013

ELECTRON J GEN MED

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Psoriasis and risk of incident myocardial infarction, stroke or transient ischaemic attack: an inception cohort study with a nested case-control analysis

Abstract: The risk of developing a cardiovascular outcome was not materially elevated for patients with early psoriasis overall. In subanalyses, however, there was a suggestion of an increased (but low absolute) MI risk for patients with psoriasis aged < 60 years, mainly with severe disease.

Cited by 177 publications

References 49 publications

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Psoriasis and Vascular Disease—Risk Factors and Outcomes: A Systematic Review of the Literature

Psoriasis, cardiovascular events, cancer risk and alcohol use: evidence‐based recommendations based on systematic review and expert opinion

The Association Between Psoriasis and Cardiovascular Diseases

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