Psoriasis and Osteoporosis: A Sex-Specific Association?

Dreiher, Jacob; Weitzman, Dahlia; Cohen, Arnon D.

doi:10.1038/jid.2008.432

Cited by 60 publications

(84 citation statements)

References 25 publications

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“…Another study which included only patients with psoriasis and controls without psoriasis revealed that osteoporosis was significantly more frequent in men with psoriasis compared with the controls, but not in women [27]. In a small study of patients with plaque psoriasis those with associated psoriatic arthropathy had a significantly lower mean lumbar spine Z-score (-1.16) than those without arthropathy (+1.38, P =0.015), while neither previous nor current treatment with systemic steroids, retinoids or methotrexate significantly affected BMD [28].…”

Section: Discussionmentioning

confidence: 99%

Osteoporosis in psoriatic arthritis: Is there any?

Grazio

Cvijetić

Vlak

et al. 2011

Wien Klin Wochenschr

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Aims: Although considered as a feature of inflammatory rheumatic diseases, there is a lot of controversy around low bone mass in patients with psoriatic arthritis. The aim of this cross-sectional study was to analyze bone mineral density in patients with psoriatic arthritis, as well as to investigate its possible association with some measures of disease activity and functional capacity. Subjects and Methods:Sixty-nine patients with established psoriatic arthritis (mean age 56.20±12.23 years) and who has not been treated with specific antiosteoporotic drugs were recruited from the outpatient clinic database. Bone mineral density was measured by dual-energy X-ray absorptiometry at the lumbar spine and at the left hip. Disease activity measures included: duration of morning stiffness, tender and swollen joint count, patient's and physician's global assessment, presence of dactylitis and enthesitis, ESR, CRP and Disease Activity Score 28. Health Assessment Questionnaire was used to assess functional status.Results: According to WHO definition, spinal osteoporosis was found in 7.2% of patients, total hip osteoporosis in 1.4% of patients and femoral neck osteoporosis in 2.9% of patients. There was no significant association of any of the measures of disease activity with BMD at any site. Higher HAQ scores were associated with lower total hip BMD.Conclusions: In our sample of patients with psoriatic arthritis we did not find increased prevalence of osteoporosis. There was no association of BMD with indices of disease activity, while negative correlation was found between HAQ and total hip BMD.

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Section: Discussionmentioning

confidence: 99%

Osteoporosis in psoriatic arthritis: Is there any?

Grazio

Cvijetić

Vlak

et al. 2011

Wien Klin Wochenschr

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“…The presence of osteoporosis in our patients might depend on a variety of factors, including inflammatory activity, history of medication use (MTX and CS), and low vitamin D levels. Busquets et al (17) studied 155 patients with PsA, of which 66% were given steroids and found that the rates of osteoporosis were 7%, 6%, and 11% for the lumbar spine, femur neck, and total hip, respectively, in the patient group, but no significant differences in BMD values were found compared with the control group. The incidence of osteoporosis in postmenopausal women with PsA (28%) was found to be higher than in men (9%) and premenopausal women (4%).…”

Section: Discussionmentioning

confidence: 99%

“…Also, women had a greater rate of osteoporosis than men in both the patient and control groups, and postmenopausal estrogen deficiency was thought to be a contributing risk factor rather than psoriasis in the etiology of osteoporosis. Similarly, osteoporosis was significantly higher in male patients with Ps than in control subjects (17). In our study, we decided to study premenopausal women in both the patient and control groups to exclude the effect of menopause on osteoporosis.…”

Section: Discussionmentioning

confidence: 99%

Relation Between Osteoporosis and Vitamin D Levels and Disease Activity in Psoriatic Arthritis

Oten¹,

Başkan²,

Sivas³

et al. 2017

Erciyes Med J

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Objective: This study investigated the relation between osteoporosis and vitamin D levels and the disease activity in patients with psoriatic arthritis (PsA). Materials and methods:In this study, 58 patients with PsA and 58 healthy controls were included. Bone mineral density (BMD) measurements of patients and controls were performed using dual-energy X-ray absorptiometry. Complete blood count, serum 25(OH)D3, parathormone, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), total calcium, ionized calcium, and phosphorous levels of all participants were measured. Disease activity was evaluated using the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Disease Activity Index for Reactive Arthritis (DAREA), and the Disease Activity Score 28 (DAS28). The functional status was evaluated using the Health Assessment Questionnaire for the spondyloarthropathies (HAQ-S), and enthesopathy was evaluated using the Maastricht Ankylosing Spondylitis Enthesitis Score (MASES).Results: BMD values of the patients were significantly lower than those of the controls. There was a negative but statistically insignificant relationship between the lateral lumbar BMD values of the patients and clinical activity signs. Vitamin D levels of the patients were significantly lower than those of the controls. Although there was no correlation between vitamin D levels and ESR and CRP levels, a negative but statistically insignificant relation was found between vitamin D levels and BASDAI, DAREA, and DAS28. The level of CRP, BASDAI, MASES, DAREA, HAQ-S, and DAS28 scores were higher in the patients with osteoporosis; however, none of the differences were statistically significant. Conclusion:In this study, the incidence of osteoporosis was higher and vitamin D levels were lower in patients than in controls.

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“…Uważa się, że u chorych z łuszczycą do czynników, które mogą negatywnie wpływać na kości, należą nadmierne spożycie alkoholu, palenie papierosów czy zmniejszenie aktywności fizycznej [21,22]. W przypadku łuszczycowego zapalenia stawów dodatkowo sugeruje się udział steroidoterapii w powstawaniu zmian o charakterze osteoporozy [9].…”

Section: Osteoporoza a łUszczycaunclassified

“…Szczególnie interesujące wydaje się badanie przeprowadzone przez Dreihera i wsp. [22], w którym wzięło udział 7936 osób z łusz-czycą w wieku 51-90 lat i 14 835 zdrowych osób. Au-torzy wykazali istotny statystycznie związek pomiędzy występowaniem łuszczycy i osteoporozy u mężczyzn, podczas gdy takiej zależności nie stwierdzono u kobiet [22].…”

Section: Osteoporoza a łUszczycaunclassified