Psoriasis and Multiple Sclerosis: Is There a Link?

Kwok, Tiffany; Loo, Wei Jing; Guenther, Lyn

doi:10.2310/7750.2010.09063

Cited by 24 publications

(20 citation statements)

References 27 publications

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“…Laroni et al also failed to show an increased prevalence of PsO in patients with MS when compared to controls (0.41% vs 0.82%, respectively). 58 Similarly, a systematic review of the literature also did not find an increased prevalence of PsO in patients with MS. 50 Finally, a comorbidity survey conducted by the National Psoriasis Foundation which spanned from 2003 to 2011 did not show an increased incidence of MS in patients with PsO. 59…”

Section: Studies Suggesting No Correlationmentioning

confidence: 97%

<p>A narrative review of psoriasis and multiple sclerosis: links and risks</p>

Silfvast‐Kaiser¹,

Homan²,

Mansouri³

2019

PTT

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The association of psoriasis (PsO) with other autoimmune and autoinflammatory diseases has long been a topic of interest. Although previous studies have attempted to clarify the specific relationship between PsO and multiple sclerosis (MS), it remains obscure, with limited and conflicting evidence regarding a link between the two entities. Herein, we review the etiology, pathogenesis, and treatment of each disease and present the available literature to-date regarding a possible relationship between PsO and MS. We conclude that further study is necessary to discern whether there may be a significant relationship between PsO and MS. In the meantime, clinicians may find it appropriate to screen for MS in patients with PsO, allowing for timely referral to a neurologist should it be necessary.

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Section: Studies Suggesting No Correlationmentioning

confidence: 97%

<p>A narrative review of psoriasis and multiple sclerosis: links and risks</p>

Silfvast‐Kaiser¹,

Homan²,

Mansouri³

2019

PTT

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“…An investigation of the prevalence of psoriasis in multiple sclerosis 14 found conflicting data from an evaluation of 19 articles. Despite the previous hypothesis that these diseases may be associated because of common immunopathogenic factors such as the dysregulation of the T‐helper (Th)17 cell pathway, it was concluded that an association could not be established from published literature.…”

Section: Comorbiditiesmentioning

confidence: 99%

What’s new in psoriasis? An analysis of guidelines and systematic reviews published in 2009-2010

Foulkes

Grindlay

Griffiths

et al. 2011

Clinical and Experimental Dermatology

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SummaryThis review summarizes key clinical findings from 5 guidelines and 21 systematic reviews on psoriasis published or indexed in the period November 2009 to October 2010. The highlights include the British Association of Dermatologists guidelines on the use of biological interventions in psoriasis, and guidelines on the efficacy and use of acitretin. Biological therapies were reviewed for use in specific patient groups (such as those with hepatitis C) and from a health-economics perspective. Another systematic review focused on outcome measures used to assess the severity of psoriasis. Finally, comorbidities including cardiovascular risk were the topic of four systematic reviews.

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“…Birinci derece akrabalarında demiyelinizan hastalık öyküsü bulunan psoriasis hastalarının TNF-α inhibitörlerini kullanmasının uygun olmadığı ifade edilmekle birlikte TNF-α inhibitörlerinin altta yatan demiyelinizan hastalığı ortaya çıkarıp çıkarmadığı bilinmemektedir. Son yıllarda, psoriasis ile demiyelinizan hastalıklardan olan MS ve periferik nöropati arasındaki ilişkiyi inceleyen epidemiyolojik çalışmalar ve olgu sunumları yapılmıştır (2)(3)(4)(5).…”

Section: Introductionunclassified

Serum Neuroinflammatory Markers’ Levels and Evaluation of Peripheral Large Nerve Fibre Function in Patients with Psoriasis

Balevi¹,

Özdemir²,

Güney³

et al. 2016

tdd

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Günümüzde tümör nekroz faktör-alfa (TNF-α) inhibitörleri, özellikle şiddetli psoriasisin tedavisinde tüm dünyada yaygın olarak kullanılmaktadırlar. Ancak psoriasisli hastalarda TNF-α inhibitör tedavisiyle ilişkilendirilmiş multipl sklerozis (MS) ve periferal nöropatiler bildirilmektedir. Psoriasis tedavisinde kullanılan TNF-α inhibitörleri, altta yatan nörolojik bozukluğu ortaya çıkarıp çıkarmadığı bilinmemektedir. Bu çalışmanın amacı; psoriasis ile multipl sklerozis ve periferal nöropatiler arasında bağlantı olup olmadığını araştırmaktır. Yöntemler: Bu çalışmada; 50 psoriasisli hasta ve 25 sağlıklı kontrol çalışmaya alındı. Nörolojik muayene ve iğne elektromiyografi testleri uygulandı. Nöroinflamatuvar süreçte rol alan matriks metalloproteinaz-2 (MMP-2), matriks metalloproteinaz-9 (MMP-9), S100 kalsiyum bağlayıcı protein (S100B) ve nöron spesifik enolaz (NSE) seviyeleri serumda ölçüldü. Bulgular: Sağlıklı kontrol grubu ile karşılaştırıldığında serum MMP-9 seviyeleri psoriasisli hastalarda yüksek tespit edilirken MMP-2 ve NSE seviyeleri psoriasisli hastalarda, sağlıklı kontrollere göre düşük tespit edildi. Serum S100B seviyeleri açısından her 2 grup arasında fark yoktu. Tüm hastalarda ve sağlıklı kontrollerde tüm nörofizyolojik parametreler normal bulundu ve 2 grup arasında fark tespit edilmedi. Sonuç: NSE ve MMP-9, psoriasisli hastalarda MS'in oluşmasında rol oynuyor olabilir. Özellikle ailesel MS öyküsü olan psoriasisli hastalarda, TNF-α inhibitörü ajan başlamadan önce bu belirteçlerin ölçülmesinin faydalı olabileceğini düşünüyoruz. Anahtar kelimeler: Psoriasis, matriks metalloproteinaz 2, matriks metalloproteinaz 9, S-100 kalsiyum-bağlayıcı protein beta alt birimi, nöron spesifik enolaz, elektromiyografi

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Psoriasis and Multiple Sclerosis: Is There a Link?

Abstract: although there are some common genetic linkages in psoriasis and MS, psoriasis does not appear to be more common in patients with MS or their relatives.

Cited by 24 publications

References 27 publications

<p>A narrative review of psoriasis and multiple sclerosis: links and risks</p>

<p>A narrative review of psoriasis and multiple sclerosis: links and risks</p>

What’s new in psoriasis? An analysis of guidelines and systematic reviews published in 2009-2010

Serum Neuroinflammatory Markers’ Levels and Evaluation of Peripheral Large Nerve Fibre Function in Patients with Psoriasis

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