Psoriasis and Hypertension: A Case-Control Study

Abstract

In recent years, numerous reports have demonstrated an association between psoriasis and metabolic syndrome. However, some studies failed to demonstrate an association between psoriasis and hypertension. The aim of the present study was to examine the association between psoriasis and hypertension. Psoriasis patients of a health-maintenance organization were compared with enrollees without psoriasis regarding the prevalence of hypertension in a case-control study. The study included 12,502 psoriasis patients over the age of 20 years and 24,285 age- and sex-frequency-matched controls. The prevalence of hypertension was significantly higher in psoriasis patients than controls (38.8%, 29.1%, respectively, p<0.001). In a multivariate analysis, hypertension was associated with psoriasis after controlling for age, sex, smoking status, obesity, diabetes, non-steroidal anti-inflammatory drugs (NSAIDs) and use of Cox-2 inhibitors (odds ratio: 1.37, 95% confidence interval: 1.29-1.46). The results of this study support the previously noted association between psoriasis and hypertension. We suggest that patients with psoriasis should be routinely screened for the presence of hypertension.

Evaluation of Soluble P-selectin and Leptin Serum Levels in Sera of Patients of Psoriasis and their Possible Role in the Increase in the Cardiovascular Risks in Psoriatic Patients

“…Results in this part of the study proved a significant increase in incidence obesity, hypertension, and type 2 diabetes mellitus (p=0.021) in psoriatic patients in group B in relation to control B group, and this findings were in agreement with the study of Al-Mutairi et al [38] Solomon et al [39] Brauchi et al [40] Cohen et al [41] of Chen et al [30] and Qureshi et al [42].…”

Psoriasis, a Systemic Disease Beyond the Skin, as Evidenced by Psoriatic Arthritis and Many Comorbities – Clinical Remission with a Leishmania Amastigotes Vaccine, a Serendipity Finding

“…The results of this study support the previously noted association between psoriasis and hypertension (Cohen et al, 2010).…”

Economic and Comorbidity Burden Among Moderate‐to‐Severe Psoriasis Patients with Comorbid Psoriatic Arthritis

“…PsO/PsA‐related comorbidities included hyperlipidemia, hypertension, diabetes mellitus, obesity, coronary heart disease, acute myocardial infarction, stroke, peripheral vascular disease, depression, anxiety, rheumatoid arthritis, Crohn's disease or ulcerative colitis, other autoimmune disorders (including alopecia areata, celiac disease, systemic sclerosis, Sjögren's syndrome, vitiligo, chronic urticaria, systemic lupus erythematosus, Addison's disease, giant cell arteritis, pulmonary fibrosis, and chronic glomerulonephritis), multiple sclerosis, skin cancer, lymphoma, and other malignancies (including cancers of the lung, pharynx, liver, pancreas, breast, vulva, penis, bladder, and kidney) 9, 10, 11, 12, 13, 14, 15, 16 (for ICD‐9‐CM codes, see Supplementary Appendix D, available in the online version of this article at http://onlinelibrary.wiley.com/doi/10.1002/acr.22492/abstract).…”

“…Besides skin and joint involvement, PsO and PsA are associated with multiple systemic comorbidities, including metabolic syndrome (e.g., hyperlipidemia, hypertension, diabetes mellitus, and obesity), other autoimmune diseases (e.g., rheumatoid arthritis and inflammatory bowel disease), and lymphoma 9, 10, 11, 12, 13. Moreover, compared with the general population, patients with PsO/PsA face an elevated burden of cardiovascular diseases due to a higher prevalence of cardiovascular risk factors such as metabolic syndrome and chronic inflammation in PsO/PsA 14, 15, 16.…”