Evaluation of Soluble P-selectin and Leptin Serum Levels in Sera of Patients of Psoriasis and their Possible Role in the Increase in the Cardiovascular Risks in Psoriatic Patients

Agamia, Naglaa Fathy

doi:10.4172/2155-9554.1000201

Cited by 3 publications

(4 citation statements)

References 50 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tamagawa-Mineoka et al [25] revealed that sP-selectin levels were markedly reduced and then returned to normal values after clinical improvement by clobetasol propionate and calcipotriol. This finding was similarly in agreement with other studies in this area like Garbaraviciene et al [64], Fathy Agamia [65], and Kwiek et al [68] who reported that effective therapy such as narrow-band phototherapy and biological drugs could significantly reduce the level of CD62P and control platelet activation in patients who had increased CD62P expression when untreated.…”

Section: In the Role Of Psoriasis Inflammationsupporting

confidence: 92%

“…What is more, P-selectin expressed on platelets was correlated closely with sP-selectin in patient plasma [64]. Furthermore, many studies showed a significant correlation between the PASI score and P-selectin expression [19, 63-65].…”

Section: In the Role Of Psoriasis Inflammationmentioning

confidence: 99%

“…It is well known that selectins generate the first step to the tethering and rolling of leukocytes which is crucial for the formation of an inflammatory infiltrate [69]. P-selectin expressed on platelets can support leukocyte rolling via the interaction between P-selectin and leukocyte P-selectin GP ligand-1, increasing the formation of leukocyte-platelet aggregates with regional recruitment of massive leukocytes from blood to the inflamed tissue and secretion of chemokines at inflamed sites [64, 65, 69, 70].…”

Section: In the Role Of Psoriasis Inflammationmentioning

confidence: 99%

See 2 more Smart Citations

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

et al. 2020

View full text Add to dashboard Cite

Background: Psoriasis is an immune-mediated inflammatory skin disease in conjunction with the systemic inflammatory process. It appears to be related to increased risks of cardiovascular disease events, especially in severe cases. The hemostatic balance is disrupted due to the prothrombotic bias in psoriasis, which might be mainly preserved by platelet hyperactivity. Platelets are also immune cells that initiate and regulate immune and inflammatory processes, except as the principal mediator of hemostasis and thrombosis, and platelet dysfunction is deeply involved in the pathogenesis of psoriasis. Summary: The aim of this study is to perform a review that expounds abnormal platelet function in psoriasis and explains the important role of platelets in the pathogenic mechanism of psoriasis in order to provide new targets for comprehensive medical treatment.

show abstract

Section: In the Role Of Psoriasis Inflammationsupporting

confidence: 92%

Section: In the Role Of Psoriasis Inflammationmentioning

confidence: 99%

Section: In the Role Of Psoriasis Inflammationmentioning

confidence: 99%

See 1 more Smart Citation

Platelet Dysfunction and Its Role in the Pathogenesis of Psoriasis

et al. 2020

View full text Add to dashboard Cite

show abstract

“…in 2017 ( 40 ), found that levels of P-selectin, especially sP-selectin, were higher in psoriasis patients than healthy controls ( Table 1 ) ( 33 – 39 ). Besides, sP-selectin levels were reduced significantly after treatments including clobetasol propionate, calcipotriol, narrow-band ultraviolet B (NB-UVB) and biological drugs ( 34 , 35 , 37 ). Intriguingly, four of these studies showed a positive correlation between sP-selectin and PASI scores ( 24 , 33 – 35 ), while the other three studies showed no correlation ( 36 – 38 ), suggesting a controversial relationship between sP-selectin and PASI scores, which may be related to the demographic characteristics or disease types (psoriasis vulgaris, psoriatic arthritis, pustular psoriasis, etc.)…”

Section: Biomarkers Of Platelet Activation Associated With Psoriasis ...mentioning

confidence: 99%

Platelet activation: a promoter for psoriasis and its comorbidity, cardiovascular disease

Jiang,

Chen

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

Psoriasis is a chronic inflammatory skin disease with a prevalence of 0.14% to 1.99%. The underlying pathology is mainly driven by the abnormal immune responses including activation of Th1, Th17, Th22 cells and secretion of cytokines. Patients with psoriasis are more likely to develop cardiovascular disease (CVD) which has been well recognized as a comorbidity of psoriasis. As mediators of hemostasis and thromboinflammation, platelets play an important part in CVD. However, less is known about their pathophysiological contribution to psoriasis and psoriasis-associated CVD. A comprehensive understanding of the role of platelet activation in psoriasis might pave the path for more accurate prediction of cardiovascular (CV) risk and provide new strategies for psoriasis management, which alleviates the increased CV burden associated with psoriasis. Here we review the available evidence about the biomarkers and mechanisms of platelet activation in psoriasis and the role of platelet activation in intriguing the common comorbidity, CVD. We further discussed the implications and efficacy of antiplatelet therapies in the treatment of psoriasis and prevention of psoriasis-associated CVD.

show abstract