Psoriasis and cardiovascular comorbidity (literature review)

Abstract

Psoriasis is a chronic immunologically associated inflammatory skin disease associated with systemic concomitant diseases, including arthritis, cardiovascular disease, kidney disease, diabetes mellitus and metabolic syndrome. The evolution of ideas about the essence of this dermatosis has led to the concept of a “psoriatic march”: psoriasis as a chronic inflammatory disease is associated with a systemic pathological process. According to numerous epidemiological studies, up to 5–7 % of the world’s population suffer from psoriasis with a continuing increase in the incidence, including severe and torpid phenotypes that lead to the most able-bodied segments of the population becoming disabled. In recent years, the question arises more often of states comorbid to psoriasis. Dermatosis is often combined with cardiovascular diseases (CVD), mental disorders, immune-mediated diseases such as Crohn’s disease, lupus erythematosus. The main factor contributing to the formation of comorbidity in psoriasis is the commonality of some links in the pathogenesis of dermatosis and the listed diseases.