Psoralen Bath Plus UV-A Therapy

Lüftl, Matthias

doi:10.1001/archderm.1997.03890480123023

Cited by 65 publications

(11 citation statements)

References 75 publications

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“…UVA radiation should preferably take place immediately (within 20 minutes) after the psoralen bath, as skin sensitization decreases relatively quickly. Skin levels of psoralen are significantly below the therapeutic range after only 30 minutes and no longer detectable after one hour .…”

Section: Photochemotherapymentioning

confidence: 90%

S1‐Guidelines on UV phototherapy and photochemotherapy

Herzinger

Berneburg

Ghoreschi

et al. 2016

J Deutsche Derma Gesell

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Known in part since antiquity, the salutary effects of sunlight again garnered increasing attention in the second half of the 19(th) century. The development of a device for ultraviolet irradiation of cutaneous tuberculosis by Finnsen at the onset of the twentieth century truly marked the beginning of modern phototherapy. In dermatology, treatment methods almost exclusively use wavelengths below the visible light range (ultraviolet light). Since the early 1970s, increasingly powerful artificial light sources have become available for UVB and UVA therapy as well as the combination of UVA and photosensitizers (photochemotherapy). High structural and procedural quality standards are an essential prerequisite for the implementation of effective as well as safe phototherapy. The following guidelines outline the current consensus of leading experts in the field of phototherapy with respect to indications, contraindications, and side effects of various treatment options available. Particular focus is also on adequate UV doses at the beginning and over the further course of treatment as well as on management of side effects.

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Section: Photochemotherapymentioning

confidence: 90%

S1‐Guidelines on UV phototherapy and photochemotherapy

Herzinger

Berneburg

Ghoreschi

et al. 2016

J Deutsche Derma Gesell

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“…(27) observed complete clearance in 5 of 11 patients and marked clinical improvement in another 4 patients. Also Kerscher et al (28) experienced a beneficial therapeutic effect of bath-water PUVA with 8-MOP in patients with MF.…”

mentioning

confidence: 86%

Bath‐water PUVA Therapy with 8‐Methoxypsoralen in Mycosis Fungoides

Weber¹,

Schmuth²,

Sepp³

et al. 2005

Acta Dermato-Venereologica

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PUVA therapy is widely used for early stage mycosis fungoides. While the efficacy of PUVA with oral 8-methoxypsoralen (8-MOP) is well documented, the use of its topical variation, bath-water PUVA therapy with 8-MOP has not been studied. The purpose of this study was to assess the effect of 8-MOP bath-water PUVA therapy in adult patients with early stage mycosis fungoides. We retrospectively evaluated the outcomes of bath-water delivery of 8-MOP (1 mg l(-1)) in 16 patients with early stage mycosis fungoides. In all patients complete response was achieved after a mean duration of 63 days requiring 29 treatments and a mean cumulative UVA dose of 33 J cm(-2). The time to relapse after complete clinical clearance was 45.6 (+/-9.2) weeks. In comparison, oral PUVA therapy with 8-MOP resulted in complete response after 64.5 days (25.8 treatments) with a mean relapse-free period of 30 (+/-3.5) weeks. We conclude that bath-water PUVA therapy with 8-MOP is a valuable photo-therapeutic alternative, which should be considered for patients in whom systemic psoralen cannot be used.

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“…However in bath PUVA the concentration of psoralens in the water is much lower than in an oil-in-water emulsion and additionally does not penetrate the lipophilic barrier of the skin as easily. Serum levels are usually extremely low or undetectable which implies minimal systemic absorption of psoralens from the PUVA bath [3,6,7,14].…”

Section: Discussionmentioning

confidence: 99%

“…In bath PUVA photochemotherapy, 8-MOP is administered in a dilute bath water solution and thus is directly applied to the skin [1,2]. Systemic adverse reactions such as nausea, vomiting and headache are avoided, in particular with local treatment applied to patients with limited skin disease [3,4]. Moreover for induction of therapeutic effects smaller doses of UVA are required.…”

Section: Introductionmentioning

confidence: 99%

High Plasma Levels of 8-Methoxypsoralen following Bath Water Delivery in Dermatological Patients

Kappes¹,

Bárta²,

Merkel

et al. 2003

Skin Pharmacol Physiol

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With respect to the clinical advantages known for bath PUVA therapy, it was of interest to compare the plasma levels of 8-methoxypsoralen (8-MOP) in bath therapy with those after oral administration for a better insight into the pharmacokinetics of 8-MOP following different modes of application. Considerable high plasma levels of 8-MOP were observed after bath therapy with interindividual variability. The half-life of plasma 8-MOP was markedly shorter after bath PUVA than after oral application. The pharmacokinetic profile of 8-MOP differs according to the mode of application.

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Psoralen Bath Plus UV-A Therapy

Cited by 65 publications

References 75 publications

S1‐Guidelines on UV phototherapy and photochemotherapy

S1‐Guidelines on UV phototherapy and photochemotherapy

Bath‐water PUVA Therapy with 8‐Methoxypsoralen in Mycosis Fungoides

High Plasma Levels of 8-Methoxypsoralen following Bath Water Delivery in Dermatological Patients

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