High Plasma Levels of 8-Methoxypsoralen following Bath Water Delivery in Dermatological Patients

Kappes, Ulrike P.; Bárta, U; Merkel, Ute; Balogh, A; Elsner, P.

doi:10.1159/000072070

Cited by 8 publications

(4 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Higher concentrations of methoxsalen may result in a better therapeutic benefit, but these concentrations bear the risk of systemic resorption of methoxsalen and therefore of systemic adverse effects. 37 The mode of action of saltwater balneophototherapy is still subject to research. It has been shown that the photosensitivity to UV-B is markedly increased (lower MED) after exposure to tap-water or saltwater baths, but no concentration-dependent effect was found.…”

Section: Commentmentioning

confidence: 99%

Bath PUVA and Saltwater Baths Followed by UV-B Phototherapy as Treatments for Psoriasis

Schiener¹,

Brockow²,

Franke³

et al. 2007

Arch Dermatol

View full text Add to dashboard Cite

To evaluate the efficacy of psoralens dissolved in a warm-water bath followed by exposure to UV-A irradiation (bath PUVA) or saltwater phototherapy (SW UV-B) compared with tap-water phototherapy (TW UV-B) or UV-B irradiation alone in psoriasis.Design: Multisite, prospective, randomized, controlled trial with 4 parallel groups.Setting: Total of 102 dermatologic outpatient clinics.Patients: Total of 1241 patients with stable psoriasis vulgaris and a Psoriasis Area and Severity Index score of 7 or greater.Interventions: Four-times-weekly UV-B, TW UV-B, SW UV-B, or bath-PUVA with baths preceding UV irradiation over a maximum of 8 weeks. The UV dose was adapted to erythemal response.Main Outcome Measures: Incidence of therapeutic success, defined as a reduction of the Psoriasis Area and Severity Index or affected body surface area of 50% or more.Results: Patients who received TW UV-B had a significantly higher incidence of therapeutic success than did patients treated with UV-B alone (60.7% vs 43.3%; PϽ.001; number needed to treat, 5.8; 95% confidence interval [CI], 3.9-10.9). Patients who received SW UV-B or bath PUVA had a significantly higher incidence of therapeutic success than did patients treated with TW UV-B (74.9% vs 60.7%; PϽ.001; number needed to treat, 7.0; 95% CI, 4.6-14.9; and 78.4% vs 60.7%; PϽ.001; number needed to treat, 5.7; 95% CI, 4.0-9.7, respectively). Bath PUVA was not superior to SW UV-B (78.4% vs 74.9%; P=.34). Conclusion:Bath PUVA and SW UV-B are comparably effective treatments in psoriasis and superior to UV-B and TW UV-B.

show abstract

Section: Commentmentioning

confidence: 99%

Bath PUVA and Saltwater Baths Followed by UV-B Phototherapy as Treatments for Psoriasis

Schiener¹,

Brockow²,

Franke³

et al. 2007

Arch Dermatol

View full text Add to dashboard Cite

show abstract

“…The mobile phase consisted of a mixture of methanol, acetonitrile and water (2:30:68) and the flow rate was 1ml/min (Monbaliu et al, 1981, Kappes et al, 2003). The linearity range was between 10-1000ng/ml ( R 2 = 0.99).…”

Section: Methodsmentioning

confidence: 99%

Transcutaneous sampling of ciprofloxacin and 8-methoxypsoralen by electroporation (ETS technique)

Sammeta

Vaka

Murthy

2009

International Journal of Pharmaceutics

View full text Add to dashboard Cite

The novel technique of transcutaneous sampling of drugs by electroporation was developed to study the dermatokinetics of ciprofloxacin and 8-methoxypsoralen. The selected drugs differ in their aqueous solubility and also with respect to the extent of protein binding. Ciprofloxacin (15mg/kg) was administered i.v. through tail vein whereas 8-methoxypsoralen (5mg/kg) was given by oral administration, in hairless rats and the time course of drug concentration in the plasma was determined. Drug concentration in the dermal ECF was determined by ETS and microdialysis sampling techniques. The extent of penetration into dermal ECF for ciprofloxacin and 8-methoxypsoralen was found to be ∼19-32% and ∼13-23% respectively. The drug concentration in the dermal ECF determined by ETS and microdialysis did not differ significantly from each other and so as were the pharmacokinetic parameters. The results show that ETS can be utilized as a potential technique for sampling of drugs from the dermal extracellular fluid.

show abstract

“…Patients take a warm bath with 0.5 -1.0 mg/l 8 - MOP for 20 min before they are exposed to UVA [ 18 ][ 19 ].…”

Section: Phototherapiesmentioning

confidence: 99%

“…For example, many studies show how nb-UVB combined with different topical drugs (e.g. Corticosteroids, vitamin D analogues, tacrolimus, pimecrolimus, pseudocatalase) could be more efficacy than phototherapy alone [ 16 ][ 17 ][ 18 ][ 19 ][ 20 ] [ 21 ][ 22 ][ 23 ][ 24 ]. In case of a combination, both TCI and vitamin D analogues should be used after UVB, never before to avoid risks such as hyperpigmentation or skin cancer.…”

Section: Phototherapiesmentioning

confidence: 99%

Vitiligo in Children: A Review of Conventional Treatments

Gianfaldoni¹,

Wollina²,

Tchernev³

et al. 2018

Open Access Maced J Med Sci

View full text Add to dashboard Cite

show abstract

High Plasma Levels of 8-Methoxypsoralen following Bath Water Delivery in Dermatological Patients

Cited by 8 publications

References 19 publications

Bath PUVA and Saltwater Baths Followed by UV-B Phototherapy as Treatments for Psoriasis

Bath PUVA and Saltwater Baths Followed by UV-B Phototherapy as Treatments for Psoriasis

Transcutaneous sampling of ciprofloxacin and 8-methoxypsoralen by electroporation (ETS technique)

Vitiligo in Children: A Review of Conventional Treatments

Contact Info

Product

Resources

About