Psoas Muscle Mass can Predict Postsurgical Outcomes in Patients Who Undergo Radical Cystectomy and Urinary Diversion Reconstruction

Stangl‐Kremser, Judith; Ahmadi, Hamed; Derstine, Brian A.; Wang, Stewart C.; Englesbe, Michael J.; Daignault‐Newton, Stephanie; Chernin, Anna S.; Montgomery, Jeffrey S.; Palapattu, Ganesh S.; Lee, Cheryl T.

doi:10.1016/j.urology.2021.08.013

Cited by 8 publications

(9 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, this concept has been frequently used when discussing the advantages or disadvantages of therapeutic strategies, as well as in cardiovascular surgery. 20 With the improvement in clinical outcomes after LVAD implantation and development of medical technology, LVAD candidates have been widely expanded to frailty seniority patients as DT. At the moment, we confront the need to assess which patients will not undergo LVAD implantation because of the expected worse postoperative prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…Frailty is a medical term that describes the scale of weakness and physical durability of patients in various disciplines. Recently, this concept has been frequently used when discussing the advantages or disadvantages of therapeutic strategies, as well as in cardiovascular surgery 20 . With the improvement in clinical outcomes after LVAD implantation and development of medical technology, LVAD candidates have been widely expanded to frailty seniority patients as DT.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Impact of psoas muscle evaluation on clinical outcomes in patients undergoing left ventricular assist device implantation

Minol

Dalyanoĝlu

Yilmaz

et al. 2022

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

AimsThe measurement of muscle mass reflects the physical components of frailty, which might affect postoperative outcomes in patients undergoing left ventricular assist device (LVAD) implantation. The aim of this study was to investigate the relationship between preoperative skeletal muscle evaluation and clinical outcomes in patients undergoing LVAD implantation.MethodsFrom January 2010 to December 2017, a total of 63 patients were enrolled in this single-centre study. A retrospective analysis of preoperative abdominal computed tomography (CT) for psoas muscle index (PSMI) and Hounsfield-Units of the Psoas Muscle (PSHU) at the level of the mid-L4 vertebra was performed.ResultsSixty-three patients (male; n = 49, 78%), with a mean age of 58.0 ± 11.8 years, were treated with LVAD due to dilated (32%) or ischemic cardiomyopathy (68%). Among them, 43 patients (68.3%) were categorized in the Interagency Registry for Mechanically Assisted Circulatory Support profile I. The survival rate was 73.0% at 30 days and 44.4% at 1 year. Receiver-operating characteristic (ROC) curve analyses revealed that PSMI was a significant numeric predictor of 1-year mortality (P = 0.04). In contrast, PSHU displayed a significant predictive potential for pericardial effusion (P = 0.03) and respiratory insufficiency (P = 0.01). In addition, comparative ROC curve analysis revealed no significant difference in the predictive potential of PSMI and PSHU.ConclusionPreoperative PSMI might be a predictor of 1-year mortality in patients undergoing LVAD implantation. In contrast, the PSHU seemed to potentially assume postoperative adverse events in this study. Thus, the evaluation of the preoperative psoas muscle using CT appears to be promising.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Impact of psoas muscle evaluation on clinical outcomes in patients undergoing left ventricular assist device implantation

Minol

Dalyanoĝlu

Yilmaz

et al. 2022

Journal of Cardiovascular Medicine

View full text Add to dashboard Cite

show abstract

“…The most widely used threshold in patients with solid tumors of the respiratory and gastrointestinal tracts is TPI <524 mm 2 /m 2 for males and <385 mm 2 /m 2 for females 18 . However, different thresholds have been used in the context of different diseases 19,35,78–90 . For example, in a study of patients with gastric cancer, the TPI threshold used was <430.0 mm 2 /m 2 for men and <343.0 mm 2 /m 2 for women 91 .…”

Section: Clinical Application Of Abdominal Ct In Diagnosing Sarcopeniamentioning

confidence: 99%

“…18 However, different thresholds have been used in the context of different diseases. 19,35,[78][79][80][81][82][83][84][85][86][87][88][89][90] For example, in a study of patients with gastric cancer, the TPI threshold used was <430.0 mm 2 /m 2 for men and <343.0 mm 2 /m 2 for women. 91 In patients with acute mesenteric ischemia, sarcopenia was defined as TPI <406.1 mm 2 /m 2 in men and as TPI <307 mm 2 /m 2 in women.…”

Section: Clinical Significance Of Abdominal Ct In Diagnosing Sarcopeniamentioning

confidence: 99%

Use of computed tomography for the diagnosis of surgical sarcopenia: Review of recent research advances

Xiao

Zhou

et al. 2022

Nut in Clin Prac

View full text Add to dashboard Cite

Sarcopenia, also known as muscle decay, is associated with high morbidity among surgical patients. It is highly correlated with adverse clinical outcomes, such as increased postoperative complications, prolonged hospital stay, and increased mortality. Computed tomography (CT) is one of the main methods for diagnosing sarcopenia, which has the advantages of intuitiveness, rapidity, and accuracy. Clinical studies have shown that CT‐defined sarcopenia can help predict the clinical outcomes and prognosis of surgical patients and provide an important reference for the formulation of antitumor treatment protocols. In recent years, some scholars have tried to construct an intelligent CT‐based diagnostic model, which is expected to improve the diagnostic efficiency and establish standardized diagnostic criteria for CT‐defined sarcopenia. In this review, we summarize the recent progress in the understanding of the diagnosis of sarcopenia and its potential prognostic value in surgery.

show abstract

“…Sarcopenia was shown to be a significant predictor for shorter overall and cancer-specific survival [ 9 , 31 ]. The PMI in BC patients has shown diverging significance in past studies [ 17 , 32 ]. Myosteatosis has rarely been investigated in BC patients.…”

Section: Introductionmentioning

confidence: 99%

Body Composition of Patients Undergoing Radical Cystectomy for Bladder Cancer: Sarcopenia, Low Psoas Muscle Index, and Myosteatosis Are Independent Risk Factors for Mortality

Engelmann

Pickl

Haas

et al. 2023

Cancers

View full text Add to dashboard Cite

Background: We assessed a wide array of body composition parameters to identify those most relevant as prognostic tools for patients undergoing radical cystectomy (RC) due to bladder cancer (BC). Methods: In this retrospective, single-center study, preoperative computed tomography (CT) scans of 657 patients were measured at the level of the 3rd lumbar vertebra (L3) to determine common body composition indices including sarcopenia, myosteatosis, psoas muscle index (PMI), subcutaneous and visceral fat index (SFI and VFI), visceral-to-subcutaneous fat ratio (VSR), and visceral obesity. Predictors of overall survival (OS) and cancer-specific survival (CSS) were identified in univariate and multivariate survival analysis. Results: Sarcopenia and a low PMI were independently associated with shorter OS (Sarcopenia: HR 1.30; 95% CI 1.02–1.66; p = 0.04 and a low PMI: HR 1.32; 95% CI 1.02–1.70; p = 0.03) and CSS (Sarcopenia: HR 1.64; 95% CI 1.19–2.25; p < 0.01 and a low PMI: HR 1.41; 95% CI 1.02–1.96; p = 0.04). Myosteatosis, measured as decreasing average Hounsfield units of skeletal muscle, was an independent risk factor for OS (HR 0.98; 95% CI 0.97–1.00; p = 0.01) and CSS (HR 0.98; 95% CI 0.96–1.00; p < 0.05). The assessed adipose tissue indices were not significant predictors for OS and CSS. Conclusions: Sarcopenia, a low PMI, and myosteatosis are independent predictors for OS and CSS in patients undergoing radical cystectomy for bladder cancer.

show abstract

Psoas Muscle Mass can Predict Postsurgical Outcomes in Patients Who Undergo Radical Cystectomy and Urinary Diversion Reconstruction

Cited by 8 publications

References 44 publications

Impact of psoas muscle evaluation on clinical outcomes in patients undergoing left ventricular assist device implantation

Impact of psoas muscle evaluation on clinical outcomes in patients undergoing left ventricular assist device implantation

Use of computed tomography for the diagnosis of surgical sarcopenia: Review of recent research advances

Body Composition of Patients Undergoing Radical Cystectomy for Bladder Cancer: Sarcopenia, Low Psoas Muscle Index, and Myosteatosis Are Independent Risk Factors for Mortality

Contact Info

Product

Resources

About