PSMA Uptake in Mediastinal Sarcoidosis

Ardies, Philip Junior; Gykiere, Pieterjan; Goethals, Laurence; Mey, Johan De; Geeter, Frank De; Everaert, Hendrik

doi:10.1097/rlu.0000000000001543

Cited by 40 publications

(18 citation statements)

References 19 publications

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“…A typical anatomic localization and 68 Ga-PSMA11 uptake pattern can be used to differentiate this nonpathologic uptake from nodal metastases. It is known that other malignant tumors or benign etiologies can also have elevated 68 Ga-PSMA11 uptake (18,(28)(29)(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Comparison of 3 Interpretation Criteria for ⁶⁸Ga-PSMA11 PET Based on Inter- and Intrareader Agreement

et al. 2019

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PET using radiolabeled prostate-specific membrane antigen (PSMA) is now being more widely adopted as a valuable tool to evaluate patients with prostate cancer (PC). Recently, 3 different criteria for interpretation of PSMA PET were published: the European Association of Nuclear Medicine (EANM) criteria, the Prostate Cancer Molecular Imaging Standardized Evaluation criteria, and the PSMA Reporting and Data System. We compared these 3 criteria in terms of interreader, intrareader, and intercriteria agreement. Methods: Data from 104 patients prospectively enrolled in research protocols at our institution were retrospectively reviewed. The cohort consisted of 2 groups: 47 patients (mean age, 64.2 y old) who underwent Glu-NH-CO-NH-Lys-(Ahx)-[ 68 Ga(HBED-CC)] (68 Ga-PSMA11) PET/MRI for initial staging of biopsy-proven intermediate-or high-risk PC, and 57 patients (mean age, 70.5 y old) who underwent 68 Ga-PSMA11 PET/CT because of biochemically recurrent PC. Three nuclear medicine physicians independently evaluated all 68 Ga-PSMA11 PET/MRI and PET/CT studies according to the 3 interpretation criteria. Two of them reevaluated all studies 6 mo later in the same manner and masked to the initial reading. The Gwet agreement coefficient was calculated to evaluate interreader, intrareader, and intercriteria agreement based on the following sites: local lesion (primary tumor or prostate bed after radical prostatectomy), lymph node metastases, and other metastases. Results: In the PET/MRI group, interreader, intrareader, and intercriteria agreement ranged from substantial to almost perfect for any site according to all 3 criteria. In the PET/CT group, interreader agreement ranged from substantial to almost perfect except for judgment of distant metastases based on the PSMA Reporting and Data System (Gwet agreement coefficient, 0.57; moderate agreement), in which the most frequent cause of disagreement was lung nodules. Intrareader agreement ranged from substantial to almost perfect for any site according to all 3 criteria. Intercriteria agreement for each site was also substantial to almost perfect. Conclusion: Although the 3 published criteria have good interreader and intrareader reproducibility in evaluating 68 Ga-PSMA11 PET, there are some factors causing interreader disagreement. Further work is needed to address this issue.

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Section: Discussionmentioning

confidence: 99%

Comparison of 3 Interpretation Criteria for ⁶⁸Ga-PSMA11 PET Based on Inter- and Intrareader Agreement

et al. 2019

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“…Several benign processes / conditions (e.g. sarcoidosis, tuberculosis, regeneration and repair, benign tumors) and a number of malignant tumors are known to be associated with PSMA expression [6,[12][13][14][15]. Specificity would be probably one of the main concerns and areas of investigation in the future.…”

Section: Discussionmentioning

confidence: 99%

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

Tolkach

Goltz

Kremer

et al. 2019

35. Jahrestagung Der Deutschen Arbeitsgemeinschaft Zum Studium Der Leber

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“…However, PSMA overexpression is not limited to prostate cancer; it is typically found in other malignant tumors, such as lung, colorectal, gastric, renal and thyroid cancer, particularly within the tumor neovasculature [ 9 – 12 ]. Furthermore, case studies have demonstrated elevated PSMA-expression in benign lesions such as sarcoidosis, Paget disease, meningioma and adrenal adenoma [ 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…Other studies have confirmed PSMA-overexpression in primary lung cancer [ 9 , 21 ]. However, case reports have demonstrated PSMA-overexpression also in benign lung lesions such as pulmonary opacities and bronchiectasis [ 22 ], sarcoidosis [ 13 ] and tuberculosis [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

68 Ga-PSMA-PET/CT for the evaluation of pulmonary metastases and opacities in patients with prostate cancer

et al. 2018

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BackgroundThe purpose of this study was to investigate the imaging properties of pulmonary metastases and benign opacities in 68Ga-PSMA positron emission tomography (PET) in patients with prostate cancer (PC).Methods68Ga-PSMA-PET/CT scans of 739 PC patients available in our database were evaluated retrospectively for lung metastases and non-solid focal pulmonary opacities. Maximum standardized uptake values (SUVmax) were assessed by two- and three-dimensional regions of interest (2D/3D ROI). Additionally CT features of the lesions, such as location, morphology and size were identified.ResultsNinety-one pulmonary metastases and fourteen opacities were identified in 34 PC patients. In total, 66 PSMA-positive (72.5%) and 25 PSMA-negative (27.5%) metastases were identified. The mean SUVmax of pulmonary opacities was 2.2±0.7 in 2D ROI and 2.4±0.8 in 3D ROI. The mean SUVmax of PSMA-positive pulmonary metastases was 4.5±2.7 in 2D ROI and in 4.7±2.9 in 3D ROI; this was significantly higher than the SUVmax of pulmonary opacities in both 2D and 3D ROI (p<0.001). The mean SUVmax of PSMA-negative metastases was 1.0±0.5 in 2D ROI and 1.0±0.4 in 3D ROI, and significantly lower than that of the pulmonary opacities (p<0.001). A significant (p<0.05) weak linear correlation between size and 3D SUVmax in lung metastases (ρSpearman=0.207) was found.ConclusionBased on the SUVmax in 68Ga-PSMA-PET alone, it was not possible to differentiate between pulmonary metastases and pulmonary opacities. The majority of lung metastases highly overexpressed PSMA, while a relevant number of metastases were PSMA-negative. Pulmonary opacities demonstrated a moderate tracer uptake, significantly lower than PSMA-positive lung metastases, yet significantly higher than PSMA-negative metastases.

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PSMA Uptake in Mediastinal Sarcoidosis

Cited by 40 publications

References 19 publications

Comparison of 3 Interpretation Criteria for ⁶⁸Ga-PSMA11 PET Based on Inter- and Intrareader Agreement

Comparison of 3 Interpretation Criteria for ⁶⁸Ga-PSMA11 PET Based on Inter- and Intrareader Agreement

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

68 Ga-PSMA-PET/CT for the evaluation of pulmonary metastases and opacities in patients with prostate cancer

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PSMA Uptake in Mediastinal Sarcoidosis

Cited by 40 publications

References 19 publications

Comparison of 3 Interpretation Criteria for 68Ga-PSMA11 PET Based on Inter- and Intrareader Agreement

Comparison of 3 Interpretation Criteria for 68Ga-PSMA11 PET Based on Inter- and Intrareader Agreement

Prostate-specific membrane antigen expression in hepatocellular carcinoma: potential use for prognosis and diagnostic imaging

68 Ga-PSMA-PET/CT for the evaluation of pulmonary metastases and opacities in patients with prostate cancer

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Comparison of 3 Interpretation Criteria for ⁶⁸Ga-PSMA11 PET Based on Inter- and Intrareader Agreement

Comparison of 3 Interpretation Criteria for ⁶⁸Ga-PSMA11 PET Based on Inter- and Intrareader Agreement