Pseudotumor cerebri syndrome associated with MIS-C: a case report

Verkuil, Lana D.; Liu, Grant T.; Brahma, Venkatesh; Avery, Robert A.

doi:10.1016/s0140-6736(20)31725-6

Cited by 45 publications

(47 citation statements)

References 4 publications

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“…Coronary arteries normal 2 weeks after discharge: recovered except general muscle weakness Verkuil et al. 31 The Lancet 2020 14 years Healthy 5 days of fever, headache, rash, diarrhea, dyspnea that progressed to septic shock requiring mechanical ventilation × 6 days. Post-extubation, new right eye abducens palsy.…”

Section: Resultsmentioning

confidence: 99%

“…Secondary pseudotumor cerebri was reported in a 14-year-old who presented after five days of fever, headache, rash, diarrhea, and dyspnea that progressed to septic shock requiring mechanical ventilation. 31 Following extubation, he had an apparent new right-eye abducens nerve palsy. Dilated fundoscopic examination revealed bilateral papilledema and left-disk hemorrhages with the remainder of his neurological examination otherwise normal.…”

Section: Resultsmentioning

confidence: 99%

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Coronavirus Infections in the Nervous System of Children: A Scoping Review Making the Case for Long-Term Neurodevelopmental Surveillance

Singer

Evankovich

Fisher

et al. 2021

Pediatric Neurology

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Background The objective of this study was to describe the case literature of human coronavirus infections in the nervous system of children, including from SARS-CoV-2, and to provide guidance to pediatric providers for managing the potential long-term effects on neurodevelopment of human coronavirus infections in the nervous system. Methods Using a structured strategy, the PubMed and Ovid:Embase databases were queried for articles about the clinical presentation and pathophysiology of coronavirus infections in the nervous system of children and young adults, aged 0 to 24 years. Results Of 2302 articles reviewed, 31 described SARS-CoV-2 infections in the nervous system of children and 21 described other human coronaviruses: HCoV-229E, HCoV-NL63, HCoV-OC43, HCoV-HKU1, MERS-CoV, SARS-CoV-1. Excepting MERS-CoV, we found cases of neurological disease in children from each human coronavirus. Children with non-SARS-CoV-2 infections have suffered acute flaccid paralysis, acute disseminated encephalomyelitis, encephalitis, and seizures. In addition, cases of ischemic, hemorrhagic, and microvascular strokes have occurred in children with SARS-CoV-2. Patients with multisystem inflammatory syndrome in children have suffered encephalitis, stroke, pseudotumor cerebri syndrome, and cytotoxic lesions of deep brain structures. Despite these reports, few articles evaluated the impact of human coronavirus infections on long-term neurodevelopmental domains including cognitive, language, academic, motor, and psychosocial outcomes. Conclusions Neurological manifestations of human coronavirus infections can cause severe disease in children. The case literature suggests a critical gap in knowledge of the long-term effects on child neurodevelopment of these infections. As the current SARS-CoV-2 pandemic continues, this gap must be filled to facilitate optimal outcomes in recovering children.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Coronavirus Infections in the Nervous System of Children: A Scoping Review Making the Case for Long-Term Neurodevelopmental Surveillance

Singer

Evankovich

Fisher

et al. 2021

Pediatric Neurology

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show abstract

“…More focal intracranial pathology, ranging from relatively benign to emergent, has been reported. Idiopathic intracranial hypertension and pseudotumor cerebri were noted in a 14-year-old girl with MIS-C and respiratory failure [ 15 ]. Another case report outlines devastating neurological sequelae possibly associated with pediatric COVID-19: a previously healthy 16-year-old boy positive for SARS-CoV-2 presented with aseptic meningitis, sphenoidal sinusitis, and cavernous sinus thrombosis on MRI.…”

Section: Clinical Observations In Childrenmentioning

confidence: 99%

Neurological issues in children with COVID-19

Lin

Asfour

Sewell

et al. 2021

Neuroscience Letters

187

207

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“…Further genomic characterization of pediatric patients with and without MIS-C could help clarify this matter. Of note, this case also adds to the limited description of pseudotumor cerebri syndrome as a possible complication of MIS-C [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 87%

Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2

Parsons

Timlin

Starr

et al. 2020

Journal of the Pediatric Infectious Diseases Society

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Multisystem inflammatory syndrome in children (MIS-C) is a newly recognized disease process that can complicate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We present what we believe to be the earliest case of MIS-C, occurring in February 2020. Our patient’s SARS-CoV-2 infection was caused by an emerging lineage with the D614G variant in the spike protein. This lineage would subsequently become the predominant cause of SARS-CoV-2 outbreaks in Europe and the United States where MIS-C was first described.

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Pseudotumor cerebri syndrome associated with MIS-C: a case report

Cited by 45 publications

References 4 publications

Coronavirus Infections in the Nervous System of Children: A Scoping Review Making the Case for Long-Term Neurodevelopmental Surveillance

Coronavirus Infections in the Nervous System of Children: A Scoping Review Making the Case for Long-Term Neurodevelopmental Surveillance

Neurological issues in children with COVID-19

Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2

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