Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2

Parsons, Emily; Timlin, M; Starr, Clarise; Fries, Anthony C; Wells, Ronald; Studer, Matthew; Sainato, Rebecca

doi:10.1093/jpids/piaa167

Cited by 7 publications

(6 citation statements)

References 8 publications

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“…To the best of our knowledge, four similar cases of PTCS associated with MIS-C (two case reports and a case series of two patients) have been reported in literature. 14 15 16 Although two patients had received therapy with doxycycline and steroids, the short course and recent initiation preclude the possibility of these medications contributing to increased intracranial pressure.…”

Section: Discussionmentioning

confidence: 99%

Pseudotumor cerebri complicating multisystem inflammatory syndrome in a child

et al. 2021

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Purpose: To report a case of pseudotumor cerebri (PTC) in a child associated with multisystem inflammatory syndrome in children (MIS-C), associated with presumed coronavirus disease 2019. Methods: A previously healthy 11-year-old female child presented with a 4-day history of fever, headache, vomiting, and loose stools. Laboratory investigations revealed neutrophilic leukocytosis, and markers of inflammation (C-reactive protein, ferritin, and interleukin-6) were significantly elevated. Pharyngeal swab for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by polymerase chain reaction was negative while anti-SARS-CoV-2 antibody was highly reactive. Ophthalmic evaluation for transient visual obscurations during hospital course revealed swelling of the optic disc in both eyes. Spectral-domain optical coherence tomography and ultrasonography confirmed the ophthalmoscopic findings. There was no neurologic deficit. Magnetic resonance imaging of the brain and magnetic resonance venogram revealed no structural lesion. The opening pressure of cerebrospinal fluid (CSF) was 336 mm of water, and CSF composition was normal. Results: A diagnosis of PTC associated with MIS-C was made, and the child was treated with oral acetazolamide. Edema of the optic disc regressed following therapy, and the child is under follow-up. Conclusions: PTC can occur in association with MIS-C. Clinicians need to be aware of this potential neuro-ophthalmic complication in MIS-C. Prompt diagnosis and treatment can prevent visual loss.

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Section: Discussionmentioning

confidence: 99%

Pseudotumor cerebri complicating multisystem inflammatory syndrome in a child

et al. 2021

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“…The main characteristics of the included studies are presented in Table 1. Fifteen studies were case report (n= 23 children), 4,5,7,8,23,[30][31][32]35,36,[38][39][40][41][42] two was a case series (n = 68), 27,43 five were prevalence studies (n= 277), 25,28,29,33,37 two were cohort studies (n= 26), 24,26 and one was a case-control study (MIS-C group= 44; KD= 7; control= 181). 34…”

Section: Resultsmentioning

confidence: 99%

Oral manifestations of multisystemic inflammatory syndrome in children (MIS‐C) and Kawasaki disease associated to COVID‐19: A systematic review

Nascimento

Araujo

Silva

et al. 2021

Special Care in Dentistry

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Aims: Multisystemic inflammatory syndrome in children (MIS-C) is a condition noted in some children asymptomatic but positive to Sars-cov-2 antibody and it presents clinical and laboratory changes similar to Kawasaki disease (KD). Oral changes have also been observed. This systematic review evaluated oral manifestations detected in children with MIS-C and KD associated to COVID-19. Methods and Results: This work was registered at PROSPERO (#CRD42020225909), following PRISMA guidelines. A comprehensive research was conducted in MEDLINE, Web of Science, EMBASE, LILACS, Scopus, and Grey Literature through August 2021, based on original research evaluating children diagnosed with MIS-C or KD related to COVID-19. Two authors independently screened all retrieved references. Twenty five selected studies evaluated 624 children, mean age 8.78 years. The assessment of the risk of bias (ROB) showed that most of them presented low ROB. Oral manifestations were erythematous mucous membrane, oral ulcers lesions, dry, swollen and cracked lips, and strawberry tongue. Conclusion: MIS-C and KD share the same oral manifestations and their identification may lead to an early diagnosis.

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“…Nessa direção, frente à recente elevação do número de casos de SIM-P no Brasil e no mundo, desde a primeira confirmação diagnóstica, há uma maior vigilância genômica do novo coronavírus. A predominância global da mutação denominada D614G, que ocorre na proteína spike do novo coronavírus, associada à entrada do patógeno nas células humanas, é aventada como hipótese para justificar o desenvolvimento da síndrome inflamatória em determinados indivíduos, uma vez que outras alterações do genoma viral foram menos correlacionadas à ocorrência da SIM-P. Sendo esta também a mutação mais frequente no Brasil e havendo aumento de diagnósticos concomitantes à segunda onda da pandemia no país, período de maior diversidade de variantes do SARS-CoV-2, a continuidade do monitoramento genético pode permitir que se defina, posteriormente, se a síndrome se correlaciona a determinadas cepas ou a outras variantes, auxiliando na identificação de regiões maior predispostas para o encontro desses tipos virais (Parsons et al, 2021).…”

Section: Discussionunclassified

Síndrome Inflamatória Multissistêmica Pediátrica (SIM-P): Uma análise epidemiológica brasileira

Brandão¹,

Rodrigues

Gomes³

et al. 2021

RSD

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O presente artigo objetivou analisar o contexto epidemiológico brasileiro da síndrome inflamatória multissistêmica pediátrica (SIM-P) temporalmente associada à Covid-19. Para tanto, realizou-se um estudo estatístico e descritivo, pautado pela interpretação de dados coletados nas plataformas das Secretarias de Saúde das 27 unidades federativas do país e que abrangeram o período entre o primeiro caso confirmado da síndrome, em 2020, até junho de 2021. Os parâmetros investigados versaram sobre o número total de casos e de óbitos, bem como à distribuição entre estados, sexos e faixas etárias. Foram registrados 1010 diagnósticos e 65 óbitos desencadeados pela síndrome, indicando uma taxa de letalidade de 6,4%. 55,4% dos casos foram descritos no sexo masculino, enquanto os óbitos, por sua vez, foram mais comuns em meninas, representando, aproximadamente, 76% das mortes verificadas. A faixa etária de maior acometimento da SIM-P foi entre 0 e 4 anos de idade. A maior parte dos casos e das mortes pela síndrome ocorreram na região sudeste, sobretudo no estado de São Paulo, que comportou 19,1% do total de diagnósticos e 18,4% da totalidade de falecimentos do Brasil. A SIM-P representa condição grave associada à infecção pelo SARS-CoV-2 e, por isso, exige cautela por parte de crianças, adolescentes e de seus familiares quanto à adequada adoção de medidas preventivas recomendadas para a Covid-19. Ainda que se trate de tema recente, os números já notificados no país são suficientes para que pediatras e generalistas obtenham o devido conhecimento médico para o diagnóstico precoce desta síndrome, permitindo a redução dos desfechos negativos e seu melhor prognóstico.

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Multisystem Inflammatory Syndrome in Children in February 2020 and Implications of Genomic Sequencing for SARS-CoV-2

Cited by 7 publications

References 8 publications

Pseudotumor cerebri complicating multisystem inflammatory syndrome in a child

Pseudotumor cerebri complicating multisystem inflammatory syndrome in a child

Oral manifestations of multisystemic inflammatory syndrome in children (MIS‐C) and Kawasaki disease associated to COVID‐19: A systematic review

Síndrome Inflamatória Multissistêmica Pediátrica (SIM-P): Uma análise epidemiológica brasileira

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